细胞粘合素(固生蛋白)抗体

英文名称    Tenascin C    

中文名称    细胞粘合素(固生蛋白)抗体    

别    名    Tn-C; Cytotactin; Glioma associated extracellular matrix antigen; GMEM; GP 150 225; Hexabrachion; HXB ; JI; Myotendinous antigen; Neuronectin; Tenascin C; TenascinC; TN; TN C; TNC; TENA_HUMAN.    

细胞粘合素(固生蛋白)抗体            

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    239kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Tn-C    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞粘合素(固生蛋白)抗体    产品介绍    background:
Tenascin, also known as hexabrachion and cytotactin, is an extracellular matrix protein with a spatially and temporally restricted tissue distribution. It is a hexameric, multidomain protein with disulfide linked subunits of 190 to 240 kD, originally characterized as 'myotendinous antigen.' In the embryo it is present in dense mesenchyme surrounding developing epithelia and in developing cartilage and bone. In the adult, tenascin remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle.

Function:
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Subunit:
Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Similarity:
Belongs to the tenascin family. 
Contains 15 EGF-like domains. 
Contains 1 fibrinogen C-terminal domain. 
Contains 15 fibronectin type-III domains.

Gene ID:
3371

Database links:

Entrez Gene: 3371 Human

Entrez Gene: 21923 Mouse

Entrez Gene: 116640 Rat

Omim: 187380 Human

SwissProt: P24821 Human

SwissProt: Q80YX1 Mouse

SwissProt: B2LYI9 Rat

Unigene: 143250 Human

Unigene: 454219 Mouse

Unigene: 980 Mouse

Unigene: 12723 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

细胞粘合素(固生蛋白)抗体    

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