线粒体DNA拓普西异构酶Ⅰ抗体

英文名称    TOP1MT    

中文名称    线粒体DNA拓普西异构酶Ⅰ抗体    

别    名    Topoisomerase (DNA) I, mitochondrial; mitochondrial DNA topoisomerase I; DNA topoisomerase I, mitochondrial; TOP1mt; 2900052H09Rik; TOP1MT; TOP1M_HUMAN; DNA topoisomerase I, mitochondrial; mitochondrial; TOP1mt; Topoisomerase I mitochondrial.    

线粒体DNA拓普西异构酶Ⅰ抗体

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  染色质和核信号  转录调节因子  激酶和磷酸酶  线粒体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    66kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human TOP1mt    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

线粒体DNA拓普西异构酶Ⅰ抗体产品介绍    background:
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Function:
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

Subcellular Location:
Mitochondrion.

Tissue Specificity:
Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.

Similarity:
Belongs to the type IB topoisomerase family.

Gene ID:
116447

Database links:

Entrez Gene: 116447 Human

Omim: 606387 Human

SwissProt: Q969P6 Human

Unigene: 528574 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

线粒体DNA拓普西异构酶Ⅰ抗体

hz-8098R CCDC34  卷曲螺旋结构域蛋白34抗体

hz-8099R CCDC75  卷曲螺旋结构域蛋白75抗体

hz-8100R CCDC65  卷曲螺旋结构域蛋白65抗体

hz-2381R Signal recognition particle  信号识别颗粒抗体

hz-8101R CCDC157  卷曲螺旋结构域蛋白157抗体

hz-8102R CCDC90B  卷曲螺旋结构域蛋白90B抗体

hz-8103R CCDC104  卷曲螺旋结构域蛋白104抗体

hz-8104R CCDC12  卷曲螺旋结构域蛋白12抗体

hz-8105R CCDC67  卷曲螺旋结构域蛋白67抗体

hz-8106R CCDC144A  卷曲螺旋结构域蛋白144A抗体

hz-8107R CCDC129  卷曲螺旋结构域蛋白129抗体

hz-8108R CCDC107  卷曲螺旋结构域蛋白107抗体

hz-8111R CCDC116  卷曲螺旋结构域蛋白116抗体

hz-8112R CCDC117  卷曲螺旋结构域蛋白117抗体

hz-8113R CCDC127  卷曲螺旋结构域蛋白127抗体

hz-8114R CCDC138  卷曲螺旋结构域蛋白138抗体

hz-8115R CCDC144NL  卷曲螺旋结构域蛋白144NL抗体

hz-8116R CCDC56  卷曲螺旋结构域蛋白56抗体

hz-8117R CCDC146  卷曲螺旋结构域蛋白146抗体

hz-8118R CCDC147  卷曲螺旋结构域蛋白147抗体

hz-0800R ANGPTL1/Angiopoietin 1/ANG-1  血管生成素-1抗体

hz-8119R CCDC148  卷曲螺旋结构域蛋白148抗体

hz-0677R Angiopoietin 2/ANG2  血管生成素2抗体

hz-8121R CCDC153  卷曲螺旋结构域蛋白153抗体

hz-8122R CCDC158  卷曲螺旋结构域蛋白158抗体

hz-8123R CCDC160  卷曲螺旋结构域蛋白160抗体

hz-8124R CCDC22  卷曲螺旋结构域蛋白22抗体

hz-8125R CCDC25  卷曲螺旋结构域蛋白25抗体

hz-8127R CCDC28A  卷曲螺旋结构域蛋白28A抗体

hz-8128R CCDC28B  卷曲螺旋结构域蛋白28B抗体

hz-8129R CCDC36/CT74  肿瘤/睾丸抗原74抗体

hz-8130R CCDC38  卷曲螺旋结构域蛋白38抗体

hz-8131R CCDC42  卷曲螺旋结构域蛋白42抗体

hz-8132R CCDC43  卷曲螺旋结构域蛋白43抗体

hz-8133R CCDC46  卷曲螺旋结构域蛋白46抗体

hz-8134R CCDC47  卷曲螺旋结构域蛋白47抗体

hz-8135R CCDC54/NYD-SP17  卷曲螺旋结构域蛋白54抗体

hz-2415R Ankyrin G  锚定蛋白G抗体