髓系细胞触发受体2抗体

英文名称    TREM2    

中文名称    髓系细胞触发受体2抗体    

别    名    TREM-2; TREM2a; TREM2b; TREM2c; Trggering receptor expressed on myeloid cells 2; Trggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; TREM2_HUMAN.    

髓系细胞触发受体2抗体        

说 明 书    0.1ml  0.2ml      

研究领域    免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human TREM2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

髓系细胞触发受体2抗体产品介绍    background:
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Function:
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

Subunit:
Interacts with TYROBP/DAP12.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential). 
Isoform 2: Secreted (Potential).
Isoform 3: Secreted (Potential).

Tissue Specificity:
Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.

DISEASE:
Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.

Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
54209

Database links:

Entrez Gene: 54209 Human

Entrez Gene: 83433 Mouse

Omim: 605086 Human

SwissProt: Q9NZC2 Human

SwissProt: Q99NH8 Mouse

Unigene: 435295 Human

Unigene: 261623 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

髓系细胞触发受体2抗体

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hz-2298P rDen-2(rh-Dengue Virus)  重组人登革热病毒2型诊断抗原

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Y-0184 ADM (Adrenomedullin)(22-52)  肾上腺髓质素（22-52）

Y-0183 ADM (Adrenomedullin)(22-42)  肾上腺髓质素（22-42）

hz-0096P AAT(Alpha-1Anti-tiypsin)  α-1抗胰蛋白酶(抗原）

hz-2062P FPP(Fertilization Promoting Peptide)  受精促进肽

hz-0203P ACEI (Angiotensin I Converting Enzyme Inhibitor )  血管紧张素1转换酶抑制剂(抗原）

hz-0120P Acinus peptide  ACINUS 多肽抗原

hz-0706PB T4-BSA  甲状腺素T4偶联牛血清白蛋白

hz-0774P mouse IgA  小鼠IgA

hz-0004P ACTH (Adrenorticotrophin hormons)(7-23)  促肾上腺皮质激素（7-23）(抗原）

hz-0862P Insulin (from porcine pancreas)  胰岛素

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hz-2372P rHBsAg   重组乙肝病毒表面抗原

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hz-0904P-HRP Melamine/HRP  辣根过氧化物酶标记三聚氰胺

hz-1034P SP-B peptide  肺表面活性蛋白B抗原

hz-1037P DCP peptide  异常凝血酶原/脱-γ-羧基凝血酶原抗原

hz-0397P MMP-9(matrix metalloproteinase 9)  基质金属蛋白酶-9(抗原)

hz-0177P AGER(Advanced glycosylation end product-specific receptor)  晚期糖基化终末产物特异性受体(抗原）

hz-0237P 14-3-3 protein  14-3-3 蛋白（多肽抗原）

hz-2017P 14-3-3 family protein(Malus domestica (Apple) (Malus sylvestris))  植物14-3-3蛋白抗原

hz-1154P FRA1/FOSL1 peptide   FRA-1多肽蛋白

hz-0037P AIF　(Apoptosis-Inducing Factor)  调亡诱导因子(多肽片断抗原）

hz-0299P Adenylate Kinase 1 (AK-1)  腺苷酸激酶-1

hz-0115P Akt/PKB  蛋白激酶B（抗原）

hz-0861PK 2,4-D/KLH(2,4-Dichlorophenoxyacetic acid)  2，4-二氯苯氧乙酸偶联血蓝蛋白

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