微管相关蛋白α6抗体

英文名称    TUBA1C    

中文名称    微管相关蛋白α6抗体    

别    名    Alpha tubulin 6; Alpha tubulin isotype M alpha 6; bcm948; M[a]6; TUBA1C; Tubulin alpha 1C chain; Tubulin alpha-1C chain; tubulin alpha 6; Tubulin alpha 6 chain; tubulin, alpha 1c; TBA1C_HUMAN; Alpha-tubulin 6; Tubulin alpha-6 chain.    

微管相关蛋白α6抗体       

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    49kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Tubulin alpha 6    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

微管相关蛋白α6抗体  产品介绍    background:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Subunit:
Dimer of alpha and beta chains.

Subcellular Location:
Cytoplasm, cytoskeleton.

Post-translational modifications:
Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively. 
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable). 
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.

Similarity:
Belongs to the tubulin family.

Database links:

Entrez Gene: 84790 Human

Entrez Gene: 504244 Cow

Entrez Gene: 22146 Mouse

Entrez Gene: 300218 Rat

SwissProt: Q3ZCJ7 Cow

SwissProt: Q9BQE3 Human

SwissProt: P68373 Mouse

SwissProt: Q6AYZ1 Rat

Unigene: 725987 Human

Unigene: 88212 Mouse

Unigene: 154526 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

微管相关蛋白α6抗体  

hz-1295R Defensin β2/DEFB2/HBD-2  防御素β2抗体

hz-1296R Defensin β2  防御素β2抗体

hz-1350R DAP-5/p97  死亡相关蛋白5抗体

hz-1687R DAPK1  凋亡相关蛋白激酶1抗体

hz-1713R DAPK2  凋亡相关蛋白激酶2抗体

hz-1692R DAPK3/ZIP Kinase  凋亡相关蛋白激酶3抗体

hz-5834R DCBLD2  内皮细胞和平滑肌细胞衍生的神经纤毛蛋白抗体

hz-5831R ANKHD1  艾滋病病毒制约锚定蛋白抗体

hz-0399R Deltex-1  DTX1抗体

hz-0171R envelope glycoprotein (Dengue virus type-2)  登革热病毒抗体

hz-5832R ASAP3  GTP酶激活蛋白ASAP3抗体

hz-2197R polyprotein (DHAV)  鸭甲型肝炎病毒聚蛋白抗体

hz-2835R ASB2  含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族2抗体

hz-1026R Desmin/DES  结蛋白抗体

hz-5301R phospho-DES (Thr16)  磷酸化结蛋白抗体

hz-5302R phospho-DES (Thr76/Thr77)  磷酸化结蛋白抗体

hz-5836R hzP3  上皮细胞膜蛋白3抗体

hz-5838R ESAM  内皮细胞粘附分子抗体

hz-0356R Digoxin  地高辛抗体

hzm-0356M Digoxin(2E2)  地高辛单克隆抗体

hz-3673R DIO2  脱碘酶2抗体

hz-0430R DISC1 (CT)  DISC1 C端抗体

hz-5840R HEPACAM  肝细胞粘附分子抗体

hz-0428R DISC1(NT)  DISC1 N端抗体

hz-3902R Dio3  甲状腺素5'脱碘酶3抗体

hz-2423R DLK1  穿膜蛋白DLK1抗体

hz-0352R DLX4  DLX4抗体

hz-2162R DKK1  抑癌蛋白DKK1抗体

hz-2686R DKK3  抑癌蛋白DKK3抗体

hz-3577R DMT1  金属离子转运体1抗体

hz-0595R DMBT1  抑癌基因抗体

hz-5842R MIIP  IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体