微管蛋白β tubulin抗体 Tubulin β

英文名称    tubulin Beta    

中文名称    微管蛋白β tubulin抗体 Tubulin β    

别    名    Beta 4 tubulin; Beta 5 tubulin; BetaTubulin; Beta Tubulin; Beta-Tubulin; dJ40E16.7; TUBB; TUBB2; TUBB2A; TUBB5; TBB5_HUMAN; Tubulin beta chain; Tubulin beta-5 chain; tubulin beta 2A.    

微管蛋白β tubulin抗体 Tubulin β       

说 明 书    0.1ml  0.2ml      

研究领域    免疫学  神经生物学  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    50kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human tubulin Beta    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

微管蛋白β tubulin抗体 Tubulin β产品介绍    background:
Microtubules are constituent parts of the mitotic apparatus, cilia, flagella, and elements of the cytoskeleton. They consist principally of 2 soluble proteins, alpha- and beta-tubulin, each of about 55,000 kDa. Antibodies against beta Tubulin are useful as loading controls for Western Blotting. However it should be noted that levels of beta Tubulin may not be stable in certain cells. For example, expression of tubulin in adipose tissue is very low (Spiegelman and Farmer, Cell, 1982, 29(1):53-60) and therefore beta Tubulin should not be used as loading control for these tissues. 

Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. 

Subunit:
Dimer of alpha and beta chains. May interact with RNABP10 (By similarity). Interacts with PIFO. Interacts with MX1 (By similarity). 

Subcellular Location:
Cytoplasm, cytoskeleton.

Tissue Specificity:
Ubiquitously expressed with highest levels in spleen, thymus and immature brain.

Post-translational modifications:
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable). 

Similarity:
Belongs to the tubulin family.

Database links:

UniProtKB/Swiss-Prot: P07437.2

Entrez Gene: 203068 Human

Omim: 191130 Human

SwissProt: P07437 Human

SwissProt: P99024 Mouse

SwissProt: P69897 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

微管蛋白β tubulin抗体 Tubulin β

hz-9937R C11orf24  11号染色体开放阅读框24抗体

hz-9938R C11orf53  11号染色体开放阅读框53抗体

hz-9939R C11orf57  11号染色体开放阅读框57抗体

hz-9940R C11orf65  11号染色体开放阅读框65抗体

hz-9941R C11orf71  11号染色体开放阅读框71抗体

hz-9942R C11orf73  11号染色体开放阅读框73抗体

hz-9943R C11orf74  11号染色体开放阅读框74抗体

hz-9944R C12ORF4  12号染色体开放阅读框4抗体

hz-9945R C12ORF24  12号染色体开放阅读框24抗体

hz-9946R C12ORF29  12号染色体开放阅读框29抗体

hz-9947R C12ORF40  12号染色体开放阅读框40抗体

hz-9948R C12ORF42  12号染色体开放阅读框42抗体

hz-9949R C12ORF49  12号染色体开放阅读框49抗体

hz-5214R phospho-AQP2(Ser261)  磷酸化水通道蛋白2抗体

hz-5185R phospho-AQP2(Ser264)  磷酸化水通道蛋白2抗体

hz-9950R C12ORF50  12号染色体开放阅读框50抗体

hz-1253R AQP3  水通道蛋白-3抗体

hz-9951R C12ORF53  12号染色体开放阅读框53抗体

hz-9952R C12ORF54  12号染色体开放阅读框54抗体

hz-5187R phospho-AQP2(Ser269)  磷酸化水通道蛋白2抗体

hz-9953R C12ORF61  12号染色体开放阅读框61抗体

hz-9954R C12ORF63  12号染色体开放阅读框63抗体

hz-9955R C12ORF68  12号染色体开放阅读框68抗体

hz-9956R CRCT1  富含半胱氨酸C端蛋白1抗体

hz-9957R CREG2  E1A激活基因刺激蛋白2抗体

hz-9958R CWF19L1  CWF19L1蛋白抗体

hz-9959R CWH43  细胞壁合成蛋白43抗体

hz-9960R Cactin/C19orf29  19号染色体开放阅读框29抗体

hz-9961R MMAA/cblA  甲基丙二酸尿症cblA抗体

hz-9971R CREPT  肿瘤高表达细胞周期相关蛋白抗体

hz-9972R LCA5L  致盲基因LCA5样蛋白抗体

hz-9973R LCA5  致盲基因LCA5蛋白抗体

hz-9974R C21ORF56  21号染色体开放阅读框56抗体

hz-9975R C21ORF62  21号染色体开放阅读框62抗体

hz-9976R C21orf128  21号染色体开放阅读框128抗体

hz-9977R C21orf2  21号染色体开放阅读框2抗体

hz-9978R C21orf58  21号染色体开放阅读框58抗体

hz-9979R C21orf70  21号染色体开放阅读框70抗体

hz-9980R C21orf55/DnaJC28  21号染色体开放阅读框55抗体