端粒调控因子抗体

英文名称    Tankyrase    

中文名称    端粒调控因子抗体    

别    名    PARP 5a; PARP5A; PARPL; pART5; Poly [ADP-ribose] polymerase 5A; TANK 1; TANK1; Tankyrase 1; Tankyrase I; Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase; Tankyrase-1; Tankyrase1; TankyraseI; TIN 1; TIN1; TINF 1; TINF1; TNKS 1; TNKS; TNKS-1; TNKS1; TNKS1_HUMAN; TRF1 interacting ankyrin related ADP ribose polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase.    

 端粒调控因子抗体   

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    142kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Tankyrase    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.    

 端粒调控因子抗体 产品介绍    background:
Tankyrase-1 and the closely related homolog Tankyrase-2 arepoly(ADP-ribose) polymerases (PARPs) that co-localize and use an ankyrin-repeat domain to bind diverse proteins, including TRF-1 (telomere-repeat-binding factor 1), IRAP (insulin-responsive aminopeptidase) and TAB182. Tankyrase-1 (also known as TNKS and TNKS1) and Tankyrase-2 (also known as TNKS2, TNKL and TANK2) interact with the same set of proteins and probably mediate overlapping functions, both at telomeres and in vesicular compartments. Overexpression of Tankyrase-1 in the nucleus promotes telomere elongation, suggesting that Tankyrase 1 may regulate access of telomerase to the telomeric complex. Overexpression of Tankyrase-2 in the nucleus releases endogenous TRF1 from telomeres, establishing Tankyrase-2 as a PARP with itself and TRF1 as acceptors of ADP-ribosylation, and suggesting the possibility of a role for Tankyrase-2 at telomeres. The ankyrin (ANK) domain of Tankyrase-2 comprises five subdomains that provide redundant binding sites for IRAP. Tankyrase-2 lacks the N-terminal Histidine/Proline/Serine-rich region of Tankyrase-1, but contains a corresponding ankyrin repeat region, sterile ?motif module and poly(ADP-ribose) polymerase homology domain. The gene encoding Tankyrase-2 is widely expressed, with mRNA transcripts particularly abundant in skeletal muscle and placenta.

Subunit:
Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. Interacts with AXIN1, AXIN2, BLZF1 and CASC3.

Subcellular Location:
Cytoplasm. Golgi apparatus membrane. Chromosome > centromere. Nucleus > nuclear pore complex. Chromosome > telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1.

Tissue Specificity:
Ubiquitous; highest levels in testis.

Similarity:
Contains 15 ANK repeats.
Contains 1 PARP catalytic domain.
Contains 1 SAM (sterile alpha motif) domain.

Database links:
 

UniProtKB/Swiss-Prot: O95271.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 端粒调控因子抗体 

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hz-0659R EPEC/E.coli  肠致病性大肠杆菌抗体

hz-2100R E.coli/EPEC  大肠埃希菌菌体蛋白抗体

hz-1555R E.coli O139  抗志贺毒素大肠杆菌O139抗体（仔猪水肿病志贺毒素大肠杆菌O139）

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hz-1764R EphA4  酪氨酸蛋白激酶A4抗体

hz-2764R Ephrin B  Ephrin B抗体

hz-3217R phospho-Ephrin B(Tyr329)  磷酸化Ephrin B抗体

hz-3167R phospho-Ephrin B(Tyr316)  磷酸化Ephrin B抗体

hz-3128R phospho-Ephrin B(Ser300)  磷酸化Ephrin B抗体

hz-3129R phospho-Ephrin B(Tyr324/329)  磷酸化Ephrin B抗体

hz-6047R Ephrin A3/EFNA3  酪氨酸蛋白激酶A3受体抗体

hz-6048R Ephrin A5  酪氨酸蛋白激酶A5受体抗体

hz-5887R HPSE2  乙酰肝素酶样蛋白抗体

hz-0485R EphA2/Eph receptor A2  内皮细胞受体蛋白酪氨酸激酶抗体

hz-3126R Phospho-EphA2(Tyr594)  磷酸化酪氨酸蛋白激酶A2受体抗体

hz-1455R EphA4 R/Eph receptor A4  酪氨酸蛋白激酶A4受体抗体

hz-0247R EphB2 R  酪氨酸蛋白激酶受体B2抗体

hz-2343R EPO  红细胞生成素抗体

hz-1424R EPOR  红细胞生成素受体抗体

hz-3880R EPHX2  胞浆环氧化物水解酶抗体

hz-2365R Eppin  附睾蛋白酶抑制蛋白

hz-3881R EPX  嗜酸性粒细胞过氧化物酶抗体

hz-2571R EphB6  酪氨酸蛋白激酶受体B6抗体

hz-3848R EPS8  表皮生长因子受体底物8抗体

hz-0725R ERα/ESR1  雌激素受体α抗体

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hz-5890R Lumican  基膜聚糖蛋白抗体

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hz-3269R phospho-MEK1(Thr286)  磷酸化丝裂原活化蛋白激酶激酶1抗体

hz-3270R Phospho-MEK1/2(Ser218/222)  磷酸化丝裂原活化蛋白激酶激酶1/2抗体

hz-3722R Phospho-MEK1/2(Ser222)  磷酸化丝裂原活化蛋白激酶激酶1/2抗体

hz-1522R phospho-ERK1/MAPK-1/2(Thr183/185)  磷酸化丝裂原活化蛋白激酶1/2抗体

hz-5411R phospho-MEK1/MAP2K1(Ser385)   磷酸化丝裂原活化蛋白激酶1抗体

hz-5412R phospho-MEK1/MAP2K1(Thr292)  磷酸化丝裂原活化蛋白激酶1抗体

hz-1645R phospho-ERK1(Thr202/Tyr204)  磷酸化丝裂原活化蛋白激酶1抗体

hz-5413R phospho-MEK1/MAP2K1(Thr386)  磷酸化丝裂原活化蛋白激酶1抗体

hz-5414R phospho-MEK1+MEK2(Ser222/Ser226)  磷酸化丝裂原活化蛋白激酶1抗体

hz-2637R ERK1/2(p44/42 MAPK)  丝裂原活化蛋白激酶1/2抗体

hz-3016R phospho-ERK1/2(Thr202/Tyr204)( p44/42 MAPK)   磷酸化丝裂原活化蛋白激酶1/2抗体

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hz-5497R phospho-MAPK3(Tyr204)  磷酸化丝裂原活化蛋白激酶3抗体

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