获取电话英文名称 TCN2
中文名称 转钴胺素蛋白2抗体
别 名 Macrocytic anemia; TC; TC II; TC-2; TC2; TCII; TCN 2; TCO2_HUMAN; Transcobalamin 2; Transcobalamin II; Transcobalamin II; macrocytic anemia; Transcobalamin-2; Vitamin B12 binding protein 2.
转钴胺素蛋白2抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 心血管 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TCN2/Transcobalamin II
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
转钴胺素蛋白2抗体 产品介绍 background:
Transcobalamin I (TCI) and Transcobalamin II (TCII) are secreted proteins belonging to the eukaryotic cobalamin transport proteins family and also to the vitamin B12-binding protein family. The genes encoding these proteins map to chromosome 11q11-q12 and 22q12.2, respectively. Transcobalamin I is a constituent of secondary granules in neutrophils, while Transcobalamin II binds cobalamin and mediates its transport into cells. These plasma proteins are expressed in various tissues and secretions.
Function:
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Subcellular Location:
Secreted.
DISEASE:
Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.
Similarity:
Belongs to the eukaryotic cobalamin transport proteins family.
Database links:
Entrez Gene: 6948 Human
Omim: 275350 Human
SwissProt: 275350 Human
SwissProt: P20062 Human
Unigene: 417948 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Involvement in disease;Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:275350]. This results in various forms of anemia.
转钴胺素蛋白2抗体
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