英文名称 TWSG1
中文名称 扭转原肠胚形成同源蛋白1抗体
别 名 PSEC0250; TSG; TSG1; twisted gastrulation homolog 1; Twisted gastrulation protein; TWSG1_HUMAN.
规格价格 0.2ml/1480元 购买
说 明 书 0.2ml
扭转原肠胚形成同源蛋白1抗体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TWSG1 (151-223aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
扭转原肠胚形成同源蛋白1抗体 产品介绍 background:
Twisted Gastrulation Protein 1(TWSG1) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins thereby preventing BMPs from binding to their receptors. It can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex.
Function:
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development
Subunit:
nteracts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7
Subcellular Location:
Secreted
Similarity:
Belongs to the twisted gastrulation protein family.
Database links:
UniProtKB/Swiss-Prot: Q9GZX9.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
扭转原肠胚形成同源蛋白1抗体
hz-9447R BMP10 骨形态发生蛋白10抗体
hz-9448R TSPAN9/NET-5 四分子交联体9/四旋蛋白抗体
hz-9449R TET2 甲基双加氧酶TET2抗体
hz-9450R 5 MethylCytosine 5甲基胞嘧啶抗体
hz-9451R FOG1 GATA结合蛋白1伴侣蛋白抗体
hz-9452R RGS4 精神分裂症相关蛋白9抗体
hz-9453R GPBB/PYGB 脑糖原磷酸化酶抗体
hz-9454R SLC27A6/ACSVL2 脂肪酸转运蛋白6抗体
hz-9455R Hexokinase II/HxK2 己糖激酶2抗体
hz-9456R SIRT5 沉默调节蛋白5抗体
hz-9457R SLC2A4RG/GLUT4 enhancer factor 葡萄糖转运蛋白4增强因子抗体
hz-9458R TNNI3K 丝氨酸/苏氨酸蛋白激酶TNN13K抗体
hz-9459R HAND1 心脏和神经嵴衍生蛋白1抗体
hz-9460R HEXIM1/EDG1 雌激素下调基因1蛋白抗体
hz-9461R HEY2 转录因子HEY2蛋白抗体
hz-9462R HOPX/LAGY 肺癌相关蛋白Y抗体
hz-9463R SYNC/Syncoilin 微管卷曲蛋白SYNC抗体
hz-9464R IRX4 Iroquois同源蛋白4抗体
hz-9465R VANGL2 神经管畸形相关蛋白VANGL2抗体
hz-9466R LRRC10 富含亮氨酸重复蛋白10抗体
hz-9467R Dishevelled 3/DVL3 DVL3蛋白抗体
hz-9468R Nebulette 肌动蛋白结合蛋白Z盘状蛋白抗体
hz-9469R IRX5 Iroquois同源蛋白5抗体
hz-9470R MEF2B 肌细胞增强因子2B抗体
hz-9471R MESP1 心血管发育中胚层相关蛋白1抗体
hz-9472R Myocardin 促血管平滑肌细胞分化因子抗体
hz-9473R NFAT5 活化T细胞核因子5蛋白抗体
hz-9474R phospho-NFAT5 (Ser1197) 磷酸化活化T细胞核因子5蛋白抗体
hz-9475R CNN2 平滑肌钙调蛋白CNN2抗体
hz-9476R Wnt16 信号通路Wnt16抗体
hz-9477R CMYA2/PDE4DIP 心肌病相关蛋白2
hz-9478R SFRP2/SARP1 分泌细胞凋亡相关蛋白1抗体
hz-9479R SMARCD3 肌动蛋白依赖染色质调控因子SMARCD3蛋白抗体
hz-9480R SRFBP1 血清应答因子结合蛋白1抗体
hz-9481R REEP5 受体表达蛋白5/息肉相关蛋白抗体