结构蛋白家族2抗体

英文名称    TCTN2    

中文名称    结构蛋白家族2抗体    

别    名    C12orf38; FLJ12975; MKS8; OTTHUMP00000239215; OTTHUMP00000239216; Tctn2; TECT2; TECT2_HUMAN; Tectonic family member 2; Tectonic-2.    

 结构蛋白家族2抗体          

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  发育生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    74kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from Human TCTN2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 结构蛋白家族2抗体  产品介绍    background:
Defects in TCTN2 are the cause of Meckel syndrome type 8 (MKS8) [MIM:613885]. A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.

Function:
Component of the tectonic-like complex, a complexlocalized at the transition zone of primary cilia and acting as abarrier that prevents diffusion of transmembrane proteins betweenthe cilia and plasma membranes. Required for hedgehog signalingtransduction (By similarity).

Subunit:
Part of the tectonic-like complex (also named B9 complex)(By similarity).

Subcellular Location:
Membrane; Single-pass type I membraneprotein (Potential). Cytoplasm, cytoskeleton, cilium basal body (Bysimilarity). Note=Localizes at the transition zone, a regionbetween the basal body and the ciliary axoneme (By similarity).

DISEASE:
Defects in TCTN2 are the cause of Meckel syndrome type 8(MKS8) [MIM:613885]. A disorder characterized by a combination ofrenal cysts and variably associated features includingdevelopmental anomalies of the central nervous system (typicallyencephalocele), hepatic ductal dysplasia and cysts, andpolydactyly. 
Note=Defects in TCTN2 may be a cause of Joubert syndrome,a disorder presenting with cerebellar ataxia, oculomotor apraxia,hypotonia, neonatal breathing abnormalities and psychomotor delay.Neuroradiologically, it is characterized by cerebellar vermianhypoplasia/aplasia, thickened and reoriented superior cerebellarpeduncles, and an abnormally large interpeduncular fossa, givingthe appearance of a molar tooth on transaxial slices (molar toothsign). Additional variable features include retinal dystrophy andrenal disease.

Similarity:
Belongs to the tectonic family.

Database links:
UniProtKB/Swiss-Prot: Q96GX1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 结构蛋白家族2抗体  

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hz-6535R FOLH1B  细胞生长抑制蛋白26抗体（前列腺特异性膜抗原样蛋白）

hz-6536R GCET2  生发中心B淋巴细胞相关蛋白2抗体

hz-6537R HDGF  肝癌衍生生长因子抗体（高迁移率族蛋白1样蛋白2抗体）

hz-6538R HOXB2  同源盒蛋白B2抗体

hz-6539R HOXB8  同源盒蛋白B8抗体

hz-6540R HSPA6  热休克蛋白70家族蛋白6抗体

hz-6541R Id1  DNA结合抑制因子1抗体

hz-6542R LAPTM4B  溶酶体蛋白跨膜β4抗体

hz-6543R LDOC1/BCUR1  癌症亮氨酸拉链下调因子1抗体

hz-6544R LOXL2  赖氨酰氧化酶相关蛋白2抗体

hz-6545R LRRN5  富含亮氨酸重复神经元5抗体

hz-6546R Lipophilin B  亲脂性蛋白B抗体

hz-6547R MAG1  肺癌转移相关蛋白抗体

hz-6548R MARVELD1  候选肿瘤抑制基因MARVELD1抗体

hz-6549R MOBK1B/C2orf6  2号染色体开放阅读框6抗体

hz-6550R MTCP1  成熟T淋巴细胞增殖蛋白1抗体

hz-6551R Mimitin  MYC诱导线粒体蛋白抗体

hz-6552R NANOGP8  干细胞转录因子NANOGP8抗体

hz-6554R NOL8  核仁蛋白8抗体

hz-6555R NUP88  核孔复合体蛋白88抗体

hz-6556R OCC1  结肠癌过度表达蛋白1抗体

hz-6557R OCIAD2  卵巢癌免疫反应抗原抗体

hz-6558R OLFM4  凋亡蛋白OLFM44抗体

hz-6559R ORAV1  口腔癌高表达的蛋白1抗体

hz-6560R ORP4/OSBP2  氧化固醇结合蛋白4抗体

hz-6561R PAGE1  前列腺相关P抗原家族成员1抗体

hz-6562R PAI1/PLANH1/Serpine 1  内皮细胞纤溶酶原激活抑制蛋白1抗体

hz-6563R NMT1  豆蔻酰基转移酶1抗体

hz-6564R GPR171/Platelet Activating Receptor H963  G蛋白偶联受体171抗体

hz-6565R POT1  端粒保护蛋白1抗体

hz-6566R PRSS3  脑胰蛋白酶3抗体

hz-6567R HDBP2/PTTG1IP  乳头瘤病毒调控因子1抗体（锌指蛋白395）

hz-6568R PCANAP2/Prostein  前列腺癌相关蛋白2抗体

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