拓普西异构酶Ⅰ抗体

英文名称    Topoisomerase I    

中文名称    拓普西异构酶Ⅰ抗体    

别    名    DNA topoisomerase 1; DNA topoisomerase I; NUP98 fusion gene; TOP 1; TOP I; TOP1; TOP1_HUMAN; TOPI; Topoisomerase 1; Topoisomerase1; TopoisomeraseI; Type I DNA topoisomerase.    

 拓普西异构酶Ⅰ抗体      

说 明 书    0.1ml  0.2ml      

研究领域    

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    91kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Topoisomerase I    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 拓普西异构酶Ⅰ抗体产品介绍    background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

Function:
The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another.

Subcellular Location:
Nucleus, nucleolus. Nucleus, nucleoplasm. Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli.

Post-translational modifications:
Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment.

DISEASE:
Note=A chromosomal aberration involving TOP1 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with NUP98.

Similarity:
Belongs to the eukaryotic type I topoisomerase family.

Gene ID:
7150

Database links:

Entrez Gene: 7150 Human

Entrez Gene: 21969 Mouse

Entrez Gene: 64550 Rat

Entrez Gene: 281539 Cow

Omim: 126420 Human

SwissProt: P11387 Human

SwissProt: Q04750 Mouse

SwissProt: Q9WUL0 Rat

Unigene: 472737 Human

Unigene: 712686 Human

Unigene: 217233 Mouse

Unigene: 91572 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 拓普西异构酶Ⅰ抗体

hz-3216R phospho-HDAC7 (Ser318)  磷酸化组蛋白去乙酰化酶7抗体

hz-2891R HDAC8  组蛋白去乙酰化酶8抗体

hz-3127R phospho-HDAC8(Ser39)  磷酸化组蛋白去乙酰化酶8抗体

hz-2892R HDAC9  组蛋白去乙酰化酶9抗体

hz-2893R HDAC10  组蛋白去乙酰化酶10抗体

hz-2894R HDAC11  组蛋白去乙酰化酶11抗体

hz-2895R HDAC12  组蛋白去乙酰化酶12抗体

hz-0287R His tag  聚组氨酸抗体标签抗体

hzm-0287M His tag(2D5)  小鼠抗聚组氨酸单克隆抗体

hz-3992R Hexokinase 1  己糖激酶1抗体

hz-3993R Hexokinase 2/HK2  己糖激酶2抗体

hz-3994R Hexokinase 3  己糖激酶3抗体

hz-0899R His tag(CT)  聚组氨酸抗体g标签抗体（C端）

hz-0833R FLAG Tag (NT)  FLAG Tag标签抗体（N端）

hz-0879R FLAG Tag (CT)  FLAG Tag标签抗体（C端）

hz-0965R FLAG Tag(CT)  FLAG Tag标签抗体（C端）

hz-2735R GstP1/GST class-pi  谷胱甘肽硫转移酶pi基因抗体

hz-2107R T7 tag  T7 tag标签抗体

hz-2109R V5 tag  V5 tag标签抗体

hz-2112R KT3 tag  KT3 tag抗体

hz-2110R VSV-G tag  VSV-G tag标签抗体

hz-0241R HIV gp120  艾滋病病毒抗体

hz-0239R HIV gp41  艾滋病病毒抗体

hz-0785R HIV-1 ENV(gp160)  艾滋病病毒-1包膜糖蛋白抗体

hz-0786R HIV-1 ENV (gp160)  艾滋病病毒-1包膜糖蛋白抗体

hz-2355R HLA Class 1 ABC/HLAabc  人类白细胞抗原A抗体

hz-2387R MHC class I  组织相容性复合体1多肽抗体

hz-4107R MHC Class II/MRC OX-6  组织相容性复合体2抗体

hz-4298R HLA DMβ  组织相容性复合体β抗体

hz-1198R HLA-DR  HLA-DR抗体

hz-0752R HLA B/HLA G  人类白细胞抗原G抗体

hz-1279R HLA E  人类白细胞抗原E抗体

hz-1030R HMGA1/HMG-I/HMG-Y  高迁移率族蛋白A1抗体

hz-0556R HMGA2  高迁移率族蛋白A2抗体

hz-0664R HMGB1  高迁移率族蛋白B1抗体

hz-1820R HMGB4  高迁移率族蛋白B4抗体

hz-5067R HMGCL  三羟基三甲基辅酶A裂解酶抗体

hz-5068R HMGCR  三羟基三甲基辅酶A还原酶抗体

hz-4063R phospho-HMGCR(Ser872)  磷酸化三羟基三甲基辅酶A还原酶抗体