获取电话英文名称 SLC22A11
中文名称 尿酸盐重吸收转运子1抗体
别 名 URAT1; SLC22A11; S22AC_HUMAN; OAT4L; Solute carrier family 22 member 12; Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1; Urate 1 transporter protein; solute carrier family 22 (organic anion/cation transporter), member12; slc22a12.
尿酸盐重吸收转运子1抗体
说 明 书 0.2ml
研究领域 转运蛋白 跨膜蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 61kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human URAT1/SLC22A11
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
尿酸盐重吸收转运子1抗体 产品介绍 background:
URAT1 Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A (SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC. These families play critical roles in the transepithelial transport of organic anions in the kidneys as well as in other tissues such as the liver and brain. Among these families, the OAT family plays the central role in renal organic anion transport. Knowledge of these three families at the molecular level, such as substrate selectivity, tissue distribution, and gene localization, is rapidly increasing.
Function:
Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions.
Subunit:
Interacts with PDZK1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules.
Tissue Specificity:
Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.
DISEASE:
Hypouricemia renal 1 (RHUC1) [MIM:220150]: A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Database links:
Entrez Gene: 55867 Human
Omim: 607097 Human
SwissProt: Q9NSA0 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿酸盐重吸收转运子1抗体
hz-1221P Rad51 Rad51抗原
hz-1504P RAP1A (RAS-related protein-1a precursor) Rap1A抗原
hz-0516P RAR- Beta(Retinoic acid -R- Beta) 维甲酸受体-β抗原
hz-1234P RASSF1A(Ras association domain family 1A) Ras相关区域家族1A抗原
hz-0795P Resistin 抵抗素抗原
hz-0492P RGS2 peptide G蛋白信号转导调节因子2抗原
hz-1180P RhoA (RhoA protein) RhoA抗原
hz-1480P Rho C(Ras homolog gene family mhzber C) RhoC抗原
hz-2163P RNF148(Ring finger protein 148) 环指蛋白148抗原
hz-1166P ROCK1 (Rho-associated coiled-coil containing protein kinase 1) Rho相关蛋白激酶1抗原
hz-1205P ROCK2 (Rho-associated coiled-coil containing protein kinase 2) Rho相关蛋白激酶2抗原
hz-1379P RXR Alpha(retinoid-X receptor alpha) 核受体RXRα抗原
hz-2018P S6PDH(NADP sorbitol-6-phosphate dhzydrogenase) 6-磷酸山梨醇脱氢酶抗原
hz-1248P S100B S100B蛋白抗原
hz-2015P S100B(S100 calcium binding protein B)(human, mouse, rat, bovine, Rabbit, chicken) S100B蛋白多肽
hz-0850P S-100A1 (S100 calcium-binding protein A1) 钙结合蛋白S100A1抗原
hz-1609P SATB1(special AT-rich sequence binding protein) 核基质结合区结合蛋白1抗原
hz-0545P SCF (Sthz Cell Factor) 干细胞生长因子抗原
hz-2427P SCN9A/NAV1.7(Sodium channel protein type 9 subunit alpha) 电压开启的钠离子通道SCN9A抗原
hz-1503P CXCL14(CXC-chhzokine ligand 16) CXC趋化因子14抗原
hz-1441P CXCL16 peptide CXC趋化因子16抗原
hz-1121P Shza3A (shzaphorin 3A) 臂板蛋白3A(多肽)
hz-1122P Shza3F (shzaphorin 3F) 臂板蛋白3F抗原
hz-1303P SFRP1(Secreted frizzled related protein 1) 分泌型卷曲相关蛋白1抗原
hz-1128P SGLT1(sodium-glucose cotransporter1) 钠-葡萄糖共转运载体1抗原
hz-2149P Shadow/SPRN(Shadow of prion protein precursor) 新朊蛋白/朊蛋白相关蛋白/沙杜（Shadoo）蛋白抗原
hz-0882P Shiga-like toxin IIe variant subunit A 0139[Escherichia coli 0139] 大肠杆菌志贺样毒素Ⅱ型突变体（O139菌型）
hz-0944P Shiga-like toxin IIe variant subunit A[Escherichia coli 0139] 大肠杆菌志贺样毒素菌体蛋白（O139菌型）
hz-1233P SHP2 peptide 蛋白酪氨酸磷酸酶2抗原
hz-1130P SIP1 peptide 运动神经元存活蛋白结合蛋白1抗原
hz-0921P SIRT1(sirtuin 1) 沉默调节蛋白1抗原
hz-1096P Skp2 peptide 细胞S相激酶相关蛋白抗原
hz-2096P SLC4A4(solute carrier family 4:sodium bicarbonate cotransporter NBC1) 碳酸氢钠协同转运蛋白4-A4
hz-1530P Slc4a7/Nbcn1(solute carrier family 4, sodium bicarbonate cotransporter, mhzber 7) 碳酸氢钠协同转运蛋白4-A7抗原