神经突起生长诱导因子受体UNC5D抗体

英文名称    UNC5D    

中文名称    神经突起生长诱导因子受体UNC5D抗体    

别    名    UNC5H4; UNC5D; Netrin receptor UNC5D; Netrin receptor Unc5h4; Protein unc 5 homolog D; Unc 5 homolog 4; Unc 5 homolog D (C. elegans); Unc 5 homolog D; UNC 5D; Unc5h4; FLJ16019; KIAA1777.    

神经突起生长诱导因子受体UNC5D抗体    

说 明 书    0.2ml      

研究领域    细胞生物  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    102kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human UNC5H4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

神经突起生长诱导因子受体UNC5D抗体产品介绍    background:
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.

Function:
UNC5D belongs to a family of netrin 1 receptors thought to mediate the chemorepulsive effect of netrin 1 on specific axons. On ligand binding UNC5D may mediate axon repulsion of neuronal growth cones in the developing nervous system.

Subunit:
Interacts with the cytoplasmic part of DCC

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues (By similarity). 
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis

Similarity:
Belongs to the unc-5 family. 
Contains 1 death domain. 
Contains 1 Ig-like (immunoglobulin-like) domain. 
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 
Contains 2 TSP type-1 domains. 
Contains 1 ZU5 domain. 

Database links:

Entrez Gene: 137970 Human

SwissProt: Q6UXZ4 Human

Unigene: 238889 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

神经突起生长诱导因子受体UNC5D抗体

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hz-1085P C-erbB-4/HER4/erbB-4 (epidermal growth factor receptor4)  c-erbB-4癌基因抗原

hz-1277P CFTR(cystic fibrosis transmhzbrane conductance regulator)  囊性纤维化跨膜转运调节因子抗原

hz-0775P CG6856-PA peptide  CG6856-PA抗原

hz-0539P CGA(Chromogranin A)  嗜铬粒素A抗原

hz-0543P CGB(Chromogranin B)  嗜铬粒素B抗原

hz-1150P ChRM1(muscarinic acetylcholine receptor)  毒蕈碱型乙酰胆碱受体M1抗原

hz-1289P ChRM3 peptide  毒蕈碱型乙酰胆碱受体M3抗原

hz-1059P CK18(Cytokeratin 18)  细胞角蛋白18(多肽)

hz-2043P CK18 peptide  细胞角蛋白18多肽抗原

hz-1339P CK18(Cytokeratin 18)  细胞角蛋白18抗原（C端）

hz-1792P CK14/17/42/10 peptide  细胞角蛋白14抗原

hz-1270P CK16(Cytokeratin 16)  细胞角蛋白16抗原

hz-1431P CK17(Cytokeratin 17)  细胞角蛋白17抗原

hz-1028P CK19  细胞角蛋白19多肽抗原

hz-1244P CK1/8/19 (Cytokeratin1/8/19; Keratin 1/8/19)peptide  细胞角蛋白1/8/19抗原

hz-1005P CK2(casein kinase 2)  细胞角蛋白2抗原

hz-1060P CK5(Cytokeratin 5)  细胞角蛋白5抗原

hz-1610P CK7(Cytokeratin 7)human  细胞角蛋白7抗原

hz-1106P CK8(Cytokeratin 8)  细胞角蛋白8（多肽）

hz-1330P CKIP-1(casein kinase 2 interaction protein 1)  酪蛋白激酶2相互作用蛋白1抗原

hz-1585P CLCA4(Calcium-activated chloride channel 4)  钙激活氯离子通道4抗原

hz-0548P C-Mer/MERTK (proto-oncogene tyrosine kinase)  c-mer原癌基因酪氨酸激酶抗原

hz-0842P c-Myc tag   c-Myc tag标签多肽

hz-2113P AU5 tag  AU5 tag标签抗原

hz-2114P AU1 tag peptide  AU1 tag标签多肽

hz-2115P Glu-Glu Tag peptide  Glu-Glu Tag多肽蛋白

hz-2074P CNGA2(Cyclic Nucleotide Gated Cation Alpha 2)  环核苷酸阳离子通道蛋白α2抗原

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hz-1272P CNTF(Ciliary Neurotrophic Factor)  睫状神经营养因子抗原

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hz-0549P Collagen III (Anti-Collagen Type III )  抗Ⅲ型胶原抗原(Collagen Ⅲ Ⅲ型胶原)

hz-0948P Collagen III (Anti--Collagen Type III )  Ⅲ型胶原抗原(Collagen Ⅲ Ⅲ型胶原)

hz-0806P Collagen IV  IV型胶原(Collagen Ⅳ Ⅳ 型胶原)

hz-0578P Collagen I(Anti-Collagen Type I)  I型胶原蛋白

hz-0552P Collagen V (Anti--Collagen Type V )  Ⅴ型胶原(多肽)

hz-1428P CLDN1(Claudin 1)  紧密连接蛋白1抗原

hz-2183P Claudin-11 peptide  少突胶质细胞跨膜蛋白抗原

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hz-0582P COX-1 (Prostaglandin-endoperoxide synthase-1)  前列腺素氧化环化酶1抗原

hz-2047P CPT1A peptide  肉毒碱棕榈酰基转移酶1A多肽抗原