神经突起生长诱导因子受体UNC5B抗体

英文名称    UNC5C    

中文名称    神经突起生长诱导因子受体UNC5B抗体    

别    名    UNC5H3; Alternative nameshomolog of C. elegans transmembrane receptor Unc5; Netrin receptor UNC5C; Protein unc 5 homolog C; Unc 5 homolog 3; Unc 5 homolog C; Unc5 (C.elegans homolog) c; UNC5H3; UNC5C_HUMAN.    

神经突起生长诱导因子受体UNC5B抗体         

说 明 书    0.2ml      

研究领域    细胞生物  发育生物学  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 1    

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    99kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human UNC5H3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

神经突起生长诱导因子受体UNC5B抗体  产品介绍    background:
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

Function:
UNC5C is a receptor for netrin required for axon guidance. It mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It is also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. There are two named isoforms.

Subunit:
Interacts with the cytoplasmic part of DCC

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. 

Post-translational modifications:
Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent (By similarity). 
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis

Similarity:
Belongs to the unc-5 family. 
Contains 1 death domain. 
Contains 1 Ig-like (immunoglobulin-like) domain. 
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 
Contains 2 TSP type-1 domains. 
Contains 1 ZU5 domain. 

Database links:

Entrez Gene: 8633 Human

Entrez Gene: 22253 Mouse

Entrez Gene: 362049 Rat

Omim: 603610 Human

SwissProt: O95185 Human

SwissProt: O08747 Mouse

SwissProt: Q761X5 Rat

Unigene: 388565 Human

Unigene: 24430 Mouse

Unigene: 47255 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

神经突起生长诱导因子受体UNC5B抗体  

hz-0979P CD38(mouse, rat)  CD38多肽（小鼠、大鼠）

hz-0980P CD38(human)  CD38抗原（人）

hz-1100P CD36  CD36（多肽）

hz-1520P CD7  CD7抗原

hz-1286P CD40L(CD40 Ligand/TNFSF5/CD154)  CD40L抗原

hz-0521P CD44  CD44抗原 (多肽抗原)

Y-0206 Argireline peptide   抗皱寡肽-1/六胜肽-3/阿基瑞林/乙酰六胜肽-3

Y-0207 GHRP-2 Acetate peptide(Growth hormone-releasing peptides 2)  醋酸促生长激素释放肽2

Y-0208 GHRP-6 Acetate peptide(Growth hormone-releasing peptides 6)  醋酸促生长激素释放肽6

Y-0209 Matrixyl Acetate  五胜肽/美容肽—M肽

Y-0210 MT-II(Melanotan II Acetate)  醋酸美拉诺坦II

Y-0211 Pentapeptide-3/Leuphasyl  五胜肽

Y-0212 PT141(Brhzelanotide PT-141)  雌性激素肽

hz-0522P CD45  CD45(白细胞共同抗原)

hz-1539P CD46/MCP(mhzbrane cofactor protein)rat, mouse  膜辅蛋白/内源性辅助因子活性蛋白抗原

hz-1113P CD5  CD5 多肽抗原

hz-1258P ICAM-2/CD102(intercellular adhesion molecules-2)  细胞间粘附分子-2抗原

hz-0805P CD56/NCAM1(Neural Cell Adhesion Molecule 1)  神经细胞粘附分子1抗原

hz-1036P CD62L (ELAM-1/L-Selectin )  L选择素抗原

hz-1273P E-Selectin  E选择素抗原

hz-1479P CD80/B7-1(human)  人刺激分子B7-1蛋白抗原

hz-2211P CD80/B7-1  刺激分子B7-1蛋白抗原

hz-1470P CD82/KAI1 peptide  肿瘤转移抑制蛋白1抗原

hz-1035P CD86/B7-2  CD86抗原

hz-1341P Cdc2/P34CDC2/CDK1(Cell division control protein 2)  周期素依赖激酶1抗原

hz-1448P CD339/Jagged1  CD339/Jagged1抗原

hz-1392P Cdc34 peptide  细胞周期调控因子34抗原

hz-0542P CDK1 (Cyclin-Dependent Kinase 1)  周期素依赖性激酶1抗原

hz-2076PB METH/BSA (Methamphetamine/BSA)  冰毒/甲基苯丙胺与牛血清蛋白偶联物

hz-0559P CDK5(Cyclin Dependent Kinase 5)  周期素依赖性激酶5抗原

hz-0568P CDK6 (Cyclin Dependent Kinase 6)  周期素依赖性激酶6抗原

hz-0569P CDK7/Cyclin H/MAT1  周期素依赖性激酶7抗原

hz-0570P CDK8(Cyclin Dependent Kinase 8)  周期素依赖性激酶8抗原

hz-0538P Cdkn1c/p57/Kip2 (Cyclindependent kinase inhibitor 1C)  周期蛋白依赖激酶抑制因子1C抗原