神经突起诱导因子受体UNC5B抗体

英文名称    UNC5B    

中文名称    神经突起诱导因子受体UNC5B抗体    

别    名    UNC5H2; Netrin receptor UNC5B; Netrin receptor UNC5B Precursor; p53 regulated receptor for death and life; p53 regulated receptor for death and life protein 1; p53-regulated receptor for death and life protein 1; p53RDL1; Protein unc-5 homolog 2; Protein unc-5 homolog B; Protein XUNC 5; Transmembrane receptor Unc5H2; Unc 5 homolog 2; Unc 5 homolog B; UNC 5B; Unc5 (C.elegans homolog) b; Unc5b; UNC5B_HUMAN; UNC5H2.    

神经突起诱导因子受体UNC5B抗体   

说 明 书    0.1ml  0.2ml      

研究领域    心血管  细胞生物  神经生物学  血管内皮细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    101kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human UNC5B    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

神经突起诱导因子受体UNC5B抗体产品介绍    background:
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Function:
FunctionReceptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. 

Subunit:
Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part. Interacts (via death domain) with DAPK1 (via death domain).

Subcellular Location:
Membrane; Single-pass type I membrane protein. Note=Associated with lipid raft. 

Tissue Specificity:
Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.

Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues (By similarity). 
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. 
Palmitoylation target the protein to the lipid rafts, and is required for pro-apoptotic activity.

Similarity:
Belongs to the unc-5 family. 
Contains 1 death domain. 
Contains 1 Ig-like (immunoglobulin-like) domain. 
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 
Contains 2 TSP type-1 domains. 
Contains 1 ZU5 domain. 

Database links:

Entrez Gene: 219699 Human

Entrez Gene: 107449 Mouse

Omim: 607870 Human

SwissProt: Q8IZJ1 Human

SwissProt: Q8K1S3 Mouse

Unigene: 522997 Human

Unigene: 290433 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

神经突起诱导因子受体UNC5B抗体

hz-0562P CCR-2/5(CC chhzokine receptor 2/5)  CC趋化因子受体2/5抗原

hz-2450P CCL1/TCA3/I-309  嗜酸粒细胞趋化蛋白CCL1抗原

hz-1324P CCL5/RANTES(regulated on activation normal T cell expressed and secreted)  活化T细胞表达和分泌的调节因子抗原

hz-2475P CCL4/MIP-1 Beta(Macrophage Inflammatory Protein 1 beta)  巨噬细胞炎性蛋白1β抗原

hz-1268P MIP3 Alpha/CCL20(Macrophage inflammatory ptotein 3 alpha)  巨噬细胞炎性蛋白3α抗原

hz-2478P CCL12/MCP-5(C-C motif chhzokine 12)  单核细胞趋化蛋白5抗原

hz-2479P CCL14/HCC-1(C-C motif chhzokine 14)  嗜酸粒细胞趋化蛋白14抗原

hz-1761P ABCD-1/CCL22  嗜酸粒细胞趋化蛋白22抗原

hz-2454P MIP-3 beta/ELC/CCL19(Macrophage Inflammatory Protein 3 Beta)  巨噬细胞炎性蛋白19抗原

hz-1762P CCL26(Eotaxin 3)  嗜酸粒细胞趋化蛋白3抗原

hz-1169P CCR-1(CC chhzokine receptor 1)  细胞表面趋化因子受体1抗原

hz-1167P CCR-3(CC chhzokine receptor 3)  CC趋化因子受体3抗原

hz-1671P CCR-2A(C-C Chhzokine receptor 2A)  细胞表面趋化因子受体2A抗原

hz-1168P CCR-4(C-C chhzokine receptor 4)  细胞表面趋化因子受体4抗原

hz-1542P CCR-6/CD196 peptide  细胞表面趋化因子受体6抗原

hz-1628P CXCR6(CXC-chhzokine receptor 6) peptide  细胞表面趋化因子受体6抗原

hz-1305P CCR-7(CC chhzokine receptor 7)  CC趋化因子受体7（多肽）

hz-1502P CXCL10/IP-10  CXCL10趋化因子10/干扰素诱导蛋白10抗原

hz-0279P VEGF(Vascular endothelial growth factor)  血管内皮生长因子（多肽抗原）

hz-0527P CD10/CALLA (Neutral Endopeptidase)  CD10抗原

hz-0354P ZCWCC1(Zinc finger CW-type coiled-coil domain protein 1)  ZCWCC1抗原

hz-0579P CD105/Endoglin/TGF- Beta receptor  CD105/转化生长因子β受体抗原

hz-1309P CD138/Syndecan-1  多配体蛋白聚糖1抗原

hz-1618P CD146/MCAM  黑色素瘤细胞粘附分子CD146抗原

hz-1383P ANPEN/CD13(Aminopeptidase N)  氨肽酶N抗原

hz-1192P CD14(cluster of differentiation antigen 14)  CD14/内毒素受体抗原

hz-1297P CD28  CD28抗原

hz-1251P CD166/ALCAM(activated leukocyte celladhesion molecule)  活化白细胞粘附分子抗原

hz-1482P CD177/NB1 peptide  嗜中性粒细胞抗原CD177抗原

hz-0528P CD24  CD24抗原

hz-0512P CD2AP (CD2-associated protein)  白细胞分化抗原CD2AP

hz-2042P CD33 peptide(human)  CD33抗原（人）

hz-1514P CD33/Siglec-3(mouse ret)  CD33抗原(大、小鼠）

hz-2038P CD34  CD34抗原（细胞表面的唾液粘蛋白）