极低密度脂蛋白受体抗体

英文名称    VLDL Receptor    

中文名称    极低密度脂蛋白受体抗体    

别    名    Very low density lipoprotein receptor; VLDL R; VLDLR; VLDL-R; VLDLRCH.    

极低密度脂蛋白受体抗体         

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  心血管  免疫学  神经生物学  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    93kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human VLDL Receptor    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

极低密度脂蛋白受体抗体    产品介绍    background:
VLDL (very low density lipoprotein) cholesterol is one of the three major types of cholesterol found in blood. VLDL receptor plays an essential role in triglyceride metabolism. It binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.

Function:
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).

Subunit:
Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17. Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.

Tissue Specificity:
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Post-translational modifications:
Ubiquitinated at Lys-839 by MYLIP leading to degradation.

DISEASE:
Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1) [MIM:224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures.

Similarity:
Contains 3 EGF-like domains.
Contains 8 LDL-receptor class A domains.
Contains 6 LDL-receptor class B repeats.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

极低密度脂蛋白受体抗体    

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hz-5620R phospho-STAT5a(Ser780)  磷酸化信号转导和转录激活因子5a抗体

hz-5621R phospho-STAT5a(Tyr694)  磷酸化信号转导和转录激活因子5a抗体

hz-1791R phospho-STAT6(Tyr641)  磷酸化信号转导和转录激活因子6抗体

hz-4254R STAT5b  信号转导和转录激活因子5b抗体

hz-5622R phospho-STAT6(Thr645)  磷酸化信号转导和转录激活因子6抗体

hz-5703R phospho-STAT5b(Ser731)   磷酸化信号转导和转录激活因子5b抗体

hz-1141R STAT3  信号转导和转录激活因子3抗体

hz-2467R STAT4  信号转导和转录激活因子4抗体

hz-3430R Phospho-Stat4 (Tyr693)  磷酸化信号转导和转录激活因子4抗体

hz-1142R STAT5  信号转导和转录激活因子5抗体

hz-1143R STAT6  信号转导和转录激活因子6抗体

hz-3753R STMN2/SCG10  神经生长相关蛋白SCG10抗体

hz-4536R Streptococcus suis 2  2型猪链球菌菌体蛋白抗体

hz-4536M Streptococcus suis 2  小鼠抗2型猪链球菌菌体蛋白抗体

hz-4537R SLY  2型猪链球菌溶血素抗体

hz-2805R Stanniocalcin 1  斯钙素抗体

hz-1903R Stra8  视黄酸激活基因8抗体

hz-1612R Astrocyte  人星形胶质细胞抗体

hz-2037R streptomycin  链霉素抗体

hz-0629R SULT1E1/Estrogen Sulfotranferase  雌激素硫酸转移酶抗体

hz-0615R Survivin  细胞凋亡抑制因子抗体

hz-3641R SUR1  磺酰脲类药物受体1抗体

hz-3797R surface layer protein  乳酸细菌表面蛋白抗体

hz-1499R SUMO 1  类泛素蛋白抗体

hz-2407R SV2A  突触泡蛋白2A抗体

hz-1905R Synphilin-1  核突触蛋白相互作用蛋白1抗体

hz-2926R Syndecan 4  多配体聚糖4抗体

hz-1729R phospho-Syndecan 4(Ser179)  磷酸化多配体聚糖4(Ser179)抗体

hz-0685R SYK  非受体型酪氨酸蛋白激酶抗体

hz-3433R Phospho-Syk (Tyr323)  磷酸化非受体型酪氨酸蛋白激酶抗体

hz-3434R Phospho-Syk (Tyr525/526)  磷酸化非受体型酪氨酸蛋白激酶抗体

hz-0679R SYVN1  滑膜细胞凋亡抑制物1抗体

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hz-0968R Alpha-Synuclein/Syn/SNCA  核突触蛋白α抗体

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hz-5626R phospho-Alpha synuclein (Tyr136)  磷酸化核突触蛋白α抗体