获取电话英文名称 Visual Arrestin
中文名称 视觉抑制蛋白抗体
别 名 V-Arrestin;Visual-Arrestin.arrestin; 48 kDa protein;Retinal S-antigen; S-AG; Rod photoreceptor arrestin.
视觉抑制蛋白抗体
说 明 书 0.2ml
研究领域 细胞生物 神经生物学 细胞膜受体 G蛋白偶联受体 G蛋白信号 细胞膜蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, cpw
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Visual Arrestin
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
视觉抑制蛋白抗体 产品介绍 background:
Members of the Arrestin/beta-Arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors, and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters or sensory signals. Visual Arrestin, also known as Arrestin, retinal S-antigen or S-Arrestin, is a major soluble photoreceptor protein that regulates light-dependent signal transduction through G protein-coupled receptor (rhodopsin) activation. Visual Arrestin is expressed in retinal photoreceptor cells and the pineal gland. Visual Arrestin is the major pathogenic autoantigen in inflammatory eye disease, such as uveoretinitis and Oguchi disease, a rare autosomal recessive form of night blindness.
Function:
Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.
Subcellular Location:
Cytoplasmic and Plasma membrane
Tissue Specificity:
Retina and pineal gland.
DISEASE:
Defects in SAG are the cause of congenital stationary night blindness Oguchi type 1 (CSNBO1) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.
Defects in SAG are the cause of retinitis pigmentosa type 47 (RP47) [MIM:613758]. RP47 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Similarity:
Belongs to the arrestin family.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视觉抑制蛋白抗体
hz-4189R ASBT/SLC10A2 顶膜钠依赖性胆盐转运体蛋白抗体
hz-0073R Neurturin 神经生长因子抗体
hz-3695R NTF97/KPNB1 亲核素β1抗体
hz-1858R Ntn1 轴突导向因子1抗体
hz-3513R Nur77/GFRP 孤儿核受体蛋白Nur77抗体
hz-3313R Phospho-Nur77(Ser351) 磷酸化孤儿核受体蛋白Nur77抗体
hz-3512R NuMA 核有丝分裂器NuMA蛋白抗体
hz-3312R Phospho-NuMA (Ser395) 磷酸化核有丝分裂器NuMA蛋白抗体
hz-3510R NUMB 膜相关蛋白Numb抗体
hz-3311R Phospho-Numb (Ser276) 磷酸化膜相关蛋白Numb抗体
hz-4028R NUP54 NUP54抗体
hz-0178R Nurr1 核受体相关因子-1抗体
hz-0687R OAS1 寡腺苷酸合成酶-1
hz-0606R OAT-1/SLC22A6 阴离子转运蛋白-1抗体
hz-0607R OAT-1/SLC22A6 阴离子转运蛋白-1抗体
hz-0609R OAT-3 阴离子转运蛋白-3抗体
hz-0603R OAT4L/URAT1 尿酸盐重吸收转运子1抗体
hz-1375R Ghrelin 28 脑肠肽抗体
hz-1495R OCLN/Occludin 紧密连接蛋白抗体
hz-1241R Claudin 5 紧密连接蛋白5抗体
hz-1075R OCT1 阳离子转运器1抗体
hz-1077R OCT2 阳离子转运蛋白2抗体
hz-4052R Oct-1 胚胎干细胞关键蛋白1抗体
hz-5017R Oct-2 胚胎干细胞关键蛋白2抗体
hz-0830R Oct-4/POU5F1 胚胎干细胞关键蛋白抗体
hz-1111R Oct-3/Oct-4 胚胎干细胞关键蛋白抗体
hz-3816R Oct-4B(OCT4B-190)NT 胚胎干细胞关键蛋白190抗体(N端)
hz-1294R ODC 鸟氨酸脱羧酶抗体
hz-3687R OGG1/8 hydroxyguanine DNA glycosylase 8-羟基鸟嘌呤DNA糖基化酶
hz-1200R Omgp 少突细胞髓磷脂糖蛋白抗体
hz-2086R ompF(putative outer mhzbrane porin F protein) 小肠结肠炎耶尔森氏菌膜通道蛋白抗体
hz-2173R OLFM1 嗅球蛋白1抗体