转录辅助因子退变样蛋白2抗体

英文名称    VGLL2    

中文名称    转录辅助因子退变样蛋白2抗体    

别    名    Protein VITO1; Transcription cofactor vestigial like 2; Transcription cofactor vestigial like protein 2; Transcription cofactor vestigial-like protein 2; Vestigial like 2; Vestigial like 2 (Drosophila); Vgl-2; VGL2; VGLL 2; Vgll2; VGLL2_HUMAN; VITO1.    

转录辅助因子退变样蛋白2抗体      

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导  干细胞  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    33kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human VGLL2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

转录辅助因子退变样蛋白2抗体产品介绍    background:
Vgl-2, also known as VITO-1, is a 317 amino acid protein that contains a domain through which it interacts with TEF-1, a protein that plays a role in controlling the expression of numerous genes. Specific to skeletal muscle, Vgl-2 is expressed highly in adult fast muscle and is expressed at lower levels in adult slow muscle and fetal skeletal muscle. During muscle differentiation, Vgl-2 mRNA levels increase and Vgl-2 translocates from the cytoplasm to the nucleus. Overexpression of Vgl-2 in MYOD-transfected 10T1/2 mouse embryonic fibroblasts increases expression of myosin heavy chain (MHC), which is a marker of terminal muscle differentiation. This evidence suggests that Vgl-2 is essential for muscle gene expression. There are two isoforms of Vgl-2 that are produced as a result of alternative splicing events. 

Function:
May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles. 

Subunit:
Interacts with TEFs. Binds to TEAD1/TEF1. 

Subcellular Location:
Nucleus.

Tissue Specificity:
Skeletal muscle.

Similarity:
Belongs to the vestigial family. 

Gene ID:
245806

Database links:

Entrez Gene: 245806 Human

Entrez Gene: 215031 Mouse

Omim: 609979 Human

SwissProt: Q8N8G2 Human

SwissProt: Q8BGW8 Mouse

Unigene: 99324 Human

Unigene: 87237 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

转录辅助因子退变样蛋白2抗体

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