获取电话?阿戈美拉汀
≥98%(HPLC)
Product Name: Agomelatine
| CAS号: | 138112-76-2 |
| 分子式: | C15H17NO2 |
| 分子量: | 243.30 |
| MDL号: | MFCD00916659 |
?阿戈美拉汀
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| 介绍: | Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. It is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties. In neurogenesis assays, both in vitro and in vivo, the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C, demonstrating actions through all three receptors. |
| 贮存: | 储存温度 2-8°C |
| 生化和生理学机理: | Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant. Agomelatine is an antidepressant drug. |
?阿戈美拉汀
BR，分子量3000
BR，分子量5000
BR，分子量10万
BR，分子量24万
BR，分子量45万
BR，分子量125万
BR，分子量300万
Q18961,3-二羟基萘/1,3-萘二酚/萘间二酚/间萘二酚/间二萘酚/1,3-DihydroxynaphthaleneBR，99%
Q1897硫代乳酸/β-巯基丙酸/硫代丙醇酸/巯基丙酸/3-巯基丙酸/β-硫代丙醇酸/β-硫氢基丙酸/3-硫代乳酸/3-Mercaptopropionic acidBR，98%
Q1898六氟异丙醇/1,1,1,3,3,3-六氟-2-丙醇/1,1,1,3,3,3-六氟代-2-丙醇/1,1,1,3,3,3-六氟异丙醇/HFIPBR，99.5%
Q1899三氯化碘/Iodine trichlorideAR，97%
Q1900一氯化碘/氯化碘/单氯化碘/ChloroiodideAR，99%
Q19011-溴癸烷/癸基溴/溴代癸烷/溴癸烷/溴代正癸烷/1-溴代癸烷/溴代葵烷/溴十二烷/1-BromodecaneAR，98%
Q19026-溴乙酸/6-溴己酸/6-溴代己酸/6-溴己烯酸/6-溴已酸/6-溴正己酸/6-Bromohexanoic acidAR，98%
Q1903四丙基溴化铵/四丙溴化铵/溴化四丙铵/四正丙基溴化铵/溴化四丙基铵/Tetrapropylammonium bromideAR，98%
Q1905甲醇钠盐/甲氧基钠/甲醇钠/甲氧化钠/Sodium methoxideAR，97%
Q1906二烯丙基二硫醚/二(2-丙烯基)二硫/二硫化二丙烯/二烯丙基二硫化物/烯丙基二硫/Allyl disulfideBR，80%
Q1907吩嗪乙基硫酸盐/吩嗪硫酸乙酯/Phenazine ethosulfateBR，95%
Q19085-氨基颉草酸/5-氨基戊酸/5-氨基正戊酸/戊氨酸/5-氨戊酸/5-Aminovaleric acidBR，97%
Q19093-羟基丁酸/DL-3-羟基-n-丁酸/DL-3-羟基丁酸/3-Hydroxybutyric acidBR，75%
Q1910β-丙内酯/β-丙酰内酯/羟基丙酸-β-内酯/已内酯/丙醇酸丙酯/β-丙酸内酯/β-PropiolactoneBR，95%
Q1911吡硫鎓钠/2-巯基吡啶氧化物钠盐/2-巯基-N-氧化吡啶钠/2-巯基吡啶-N-氧化物钠盐/吡啶硫酸钠/吡啶硫酮钠/2-巯基吡啶-1-氧化钠盐/α-巯基吡啶-N-氧化物钠/奥麦丁钠/吡硫霉净/2-Mercaptopyridine N-oxide sodium saltAR，96%
Q1912苯甲硫醚/苯硫基甲烷/茴香硫醚/甲基苯基硫醚/甲基苯基硫化物/硫代苯甲醚/苯基甲基硫醚/Methyl phenyl sulfideBR，99%
Q1913聚乙烯硫酸钾/聚乙烯硫酸酯钾盐/聚二乙烯磺酸钾/聚乙烯磺酸甲盐/聚乙烯基硫酸钾/PVSKBR
Q1914N-乙基二异丙胺/N，N-二异丙基乙胺/二异丙基乙胺/二异丙基乙基胺/N,N-异丙基乙胺/DIPEABR，99%
Q19151-(3-氯苯基)哌嗪盐酸盐/1-(3-氯苯基)哌嗪单盐酸盐/1-(3-Chlorophenyl)piperazine hydrochlorideBR，98%
Q1916利巴韦林/1-β-D-呋喃核糖基-1H-1,2,4,-三氮唑-3-羧酰胺/1-β-D呋喃核糖-1,2,4-三氮唑-3-羟酰胺/病毒唑/三氮唑核苷/三氨唑核苷/三唑核苷/RibavirinBR，98%
Q19181,2,4,5-苯四甲酸酐/1,2,4,5-苯四甲羧酸二酐/1H,3H-苯并[1,2-C:4,5-C’]二呋喃-1,3,5,7-四酮/苯均四酸酐/1,2,4,5-均苯四甲酸二酐/均苯四甲酸二酐/均苯四甲酸酐/1,2,4,5-苯四酸酐/PMDAAR，98.5%
Q19192-甲基乳酸/2-羟基-2-甲基丙酸/α-羟基异丁酸/醋酮酸/2-甲基-2-羟基丙酸/2-羟基异丁酸/甲基乳酸/α-Hydroxyisobutyric acidAR，99%
Q1920氰酸钾/Potassium cyanateAR，97%
Q1921氰酸钠/异氰酸钠/Sodium cyanateAR，97%
Q1922二氨荃庚二酸/2,6-二氨基庚二酸/2,6-Diaminopimelic acidAR，98%
Q1923朱砂莲甲素/大黄素/1,3,8-三羟基-6-甲基蒽醌/泻素/2-甲基-4,5,7-三羟基蒽醌/6-甲基-1,3,8-三羟基蒽醌/泻鼠李树皮/EmodinAR，95%
Q1924氧化槐果碱/OxysophocarpineBR，98%
Q1925氧化槐定碱/OxysophoridineBR，98%
Q1926苦豆碱/AloperineBR，98%
Q1927野定碱/野靛碱/野啶碱/金链花碱/金雀花酮碱/(-)-金雀花碱/金莲花素/乌乐碱/野靛毒/金莲花碱/CytisineBR，98%
Q1928异戊烯基溴/4-溴-2-甲烷-2-丁烷/1-溴-3-甲基-2-丁烯/4-溴-2-甲烷-2-丁烯/3,3-二甲基烯丙基溴/4-溴-2-甲基-2-丁烯/1-溴-3-甲基丁烯/1-溴-3-甲烷-2-丁烯/溴代异戊烯/3,3-Dimethylallyl bromideBR，99%
Q1929二甲胺基丙基丙烯酰胺/二甲氨基丙基丙烯酰胺/N-(3-二甲氨基丙基)丙烯酰胺/N,N-二甲氨基丙基丙烯酰胺/N,N-二甲胺丙基丙烯酰胺/DMAPAABR，98%
Q1930聚四氟乙烯树脂/聚四氟乙烯/四氟乙烯的均聚物/特氟隆/铬姆沙伯T/PTFEBR
Q1931碘仿/海碘仿/黄碘/三碘甲烷/IPG干胶条/IodoformCP，99%