苦参碱价格

98%

Product Name: Matrine

苦参碱价格

用途:    抗菌消炎药，用于慢性宫颈炎、菌痢、肠炎等    

熔点:    85 °C    

特定比重:    1.16    

比旋光度:    33 ° (C=1, EtOH)    

贮存:    贮存温度2-8℃    

生化和生理学机理:    

Description:
IC50 Value: 540 μg/ml (inhibit gastric cancer cell line MNK45, MTT) [1]
Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and ?-receptor agonist.
in vitro: MTT assay showed that the matrine was able to inhibit gastric cancer cell line MNK45 in a dose-dependent manner. The concentration required for 50% inhibition (IC50) was found to be 540 μg/ml. This anti-tumor function was achieved through modulation of the NF-κB, XIAP, CIAP, and p-ERK proteins expression in cell line MNK45. Matrine induces apoptosis of human NSCLC cells with anti-apoptotic factors inhibited and dependent on caspase activity. In addition, we found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with SB202190 partially prevents matrine-induced apoptosis. Furthermore, matrine generates reactive oxygen species (ROS) in a dose- and time-dependent manner, which is reversed by pretreatment with N-acetyl-L-cysteine (NAC) [2].
in vivo: Oral administration of matrine (200, 100 and 50 mg/kg) significantly attenuated isoproterenol-induced cardiac necrosis and left ventricular dysfunction [3]. high dose of matrine significantly reduced the mortality rate of mice with LPS administration. Treatment with matrine improved LPS-induced lung histopathologic changes, alleviated pulmonary edema and lung vascular leak, inhibited MPO and MDA activity,and reduced the production of inflammatory mediators including TNF-α, IL-6 and HMGB1 [4].
Toxicity: N/A
Clinical trial: N/A

苦参碱价格

K0033青霉素钠/青霉素G钠/苄基青霉素钠/苄青霉素钠/盘尼西林/(2S,5R,6R)-3,3-二甲基-6-(2-苯乙酰氨基)-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠盐/3,3-二甲基-7-氧代-6-[(苯乙酰基)氨基]-4-硫杂-1-氮杂二环[3.2.0]庚烷-2-羧酸单钠盐/6-苯乙酰胺基青霉烷酸钠/Penicillin G Na saltUSP级，1603u/mg

组织培养级，10KU/ml

K0034青霉素钾/青霉素G钾/苄青霉素钾/苯氧丙基青霉素/苯丙青霉素钾/(2S,5R,6R)-3,3-二甲基-6-(2-苯乙酰氨基)-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钾盐/Penicillin G Potassium saltUSP级,1534u/mg

K0034-1青霉素V钾/3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸钾盐/Penicillin V potassium salt分析标准品

K0035青霉素链霉素溶液/Penicillin&Streptomycin solution,γ-Irradiated组织培养级，γ-射线灭菌

K0035-1青霉素链霉素两性霉素B溶液/Penicillin&Streptomycin&Amphotericin B solution,γ-Irradiated组织培养级，γ-射线灭菌

K0035-2青霉素链霉素新霉素溶液/Penicillin&Streptomycin&Neomycin solution,γ-Irradiated组织培养级，γ-射线灭菌

K0036土霉素/地霉素/氧四环素/4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-并四苯-2-甲酰胺/4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氢-3,5,6,10,12,12A-六羟基-6-甲基-1,11-二羰基-[4S-(4α,4Aα,5α,5Aα,6β,12Aα)]-2-萘甲酰胺/TerramycinUSP级，930u/mg

K0037盐酸土霉素/盐酸地霉素/盐酸氧四环素/(4S,4aR,5S,5aR,6S,12aS)-4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-2-并四苯甲酰胺盐酸盐/Oxytetracycline hydrochlorideUSP级，95-105%

K0038罗红霉素/9-{O-[(2-甲氧基乙氧基)-甲基]肟基}红霉素/罗力得/RoxithromycinUSP级，940u/mg

K0039伊曲康唑/依他康唑/斯皮仁诺/4-[4-[4-[4-[[cis-2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]哌嗪-1-基]苯基]-2-[(1RS)-1-甲基丙基]-1,2,4-三唑-3-酮/4-[4-[4-[4-[[2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮/亚特那唑/ItraconazoleUSP级，98.5%

K0040氟康唑/大扶康/麦尼芬/麦道氟康/2-(2,4-二氟苯基)-1,3-双(1H-1,2,4-三唑-1-基)-2-丙醇/2-(2,4-二氟苯基)-1,3-双(1H-1,2,4-三唑-1-基)-2-丙醇/α-(2,4-二氟苯基)-Α-(1H-1,2,4-三唑-1-基甲基)-1H-1,2,4-三唑-1-基乙醇；2-(2,4-二氟苯基)-1,3-双(1H-1,2,4-三氮唑-1-基)-2-丙醇/FluconazoleUSP级，99%

K0041阿莫西林/阿摩西林三水物/阿莫西林三水物/羟氨苄青霉素三水物/6-[2-氨基-2-(4-羟基苯基)乙酰氨基]-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸三水物/Amoxicillin trihydrateUSP级，95%

K0042酮康唑/酮亢唑/顺-1-乙酰基-4-[4-[[2-(2,4-二氯苯基)-2-(1H-咪唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]哌嗪/Ketoconazole/R41400USP级，98%

K0043盐酸洛美沙星/(±)-1-乙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧喹啉-3-羧酸盐酸盐/盐酸氟罗沙星/Lomefloxacin hydrochlorideUSP级，98%

K0044盐酸克林霉素/克林霉素盐酸盐/盐酸林大霉素/盐酸氯洁霉素/氯林可霉素/Clindamycin HydrochlorideUSP级，83%，800u/mg

K0045磷霉素钠/磷雷素钠/Phosphomycin disodium saltUSP级，720IU/mg

K0046硫酸阿米卡星/硫酸丁胺卡那霉素/阿米卡霉素/O-3-氨基-3-脱氧-alpha-D-葡吡喃糖基-(1→6)-O-[(6-氨基-6-脱氧-alpha-D-葡吡喃糖基-(1→4)]-N-(4-氨基-2-羟基-1-氧丁基)-2-脱氧-D-链霉胺硫酸盐/Amikacin sulfate salt BR，674-786ug/mg

K0046-1阿米卡星/丁胺卡那霉素/氨基羟丁基卡那霉素A/抗菌素BBK8/Amikacin试剂级，98%

K0047卡莫司汀/卡氮芥/双氯乙亚硝脲/氯乙亚硝脲/氯化亚硝脲/亚硝基脲氮芥/1,3-双(2-氯乙基)-1-亚硝基脲/Carmustine/BCNUBR，98%

K0048莫能菌酸钠/莫能星钠/摩能霉素钠/莫能霉素钠/莫能菌素钠/Monensin sodiumBR，90-95%

K0049替卡西林钠/羧噻吩青霉素钠/替卡西林二钠/(2S,5R,6R)-3,3-二甲基-6-[2-羧基-2-(2-噻吩基)乙酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸二钠盐/Ticarcillin disodium salt USP级，95%

K0050链脲佐菌素/链脲霉素/链氮霉素/链脲菌素/链佐星/链唑霉素/2-脱氧-2-[[ (甲基亚硝基氨基)羰基]-氨基]-D-吡喃葡萄糖/STZ/StreptozotocinUSP级，98.5%

K0051盐酸四环素/四环素盐酸盐/Tetracycline HC1USP级，900ug/mg

USP级，50mg/ml

K0052四环素/四环素碱/4-(二甲基氨基)-1,4,4A,5,5A,6,11,12A-八氢-3,6,10,12,12A-五羟基-6-甲基-1,11-二羰基-2-萘甲酰胺/Tetracycline生物技术级，98%

K0053头孢曲松钠/头孢三嗪噻肟/(6R,7R)-7-[[(2E)-2-(2-氨基-1,3-噻唑-4-基)-2-甲氧基亚氨乙酰]氨基]-3-[(2-甲基-5,6-二氧代-1H-1,2,4-三嗪-3-基)硫甲基]-8-氧代-5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸/Ceftriaxone sodiumBR，935ug/mg

K0053-1头孢曲松/头孢三嗪噻肟/(6R,7R)-7-[[(2E)-2-(2-氨基-1,3-噻唑-4-基)-2-甲氧基亚氨乙酰]氨基]-3-[(2-甲基-5,6-二氧代-1H-1,2,4-三嗪-3-基)硫甲基]-8-氧代-5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸/三嗪噻肟头孢菌素/氨噻三嗪头孢菌素/头孢氨噻三嗪/CeftriaxoneBR，935ug/mg

K0054头孢唑啉钠/头孢拉定V/先锋霉素V/唑啉头孢菌素钠/(6R,7R)-3-[[(5-甲基-1,3,4-噻二唑-2-基)硫]甲基]-7-[(1H-四唑-1-基)乙酰氨基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸钠盐/Cefazolin sodium saltUSP级，95%

K0055嘌呤霉素盐酸盐/二氢氯化嘌呤毒素/Puromycin dihydrochloride超纯，98%

K0056多粘菌素B硫酸盐/硫酸多粘菌素B/多胜菌素乙/多粘菌素B硫酸酯/硫酸阿罗多粘/Polymyxin B sulfateUSP级，6000u/mg

USP级，2000IU/ml

K0057多粘菌素E硫酸盐/硫酸粘杆菌素/多粘菌素E/硫酸粘菌素/粘杆菌素B/黏菌素硫酸盐/Colistin sulfate saltUSP级，19000IU/mg

K0058链霉素硫酸盐/硫酸链霉素/O-2-脱氧-2-甲氨基-alpha-L-葡吡喃糖基-(1→2)-O-5-脱氧-3-C-甲酰基-alpha-L-来苏呋喃糖基-(1→4)-N1,N3-二脒基-D-链霉胺硫酸盐/2,4-二胍基-3,5,6-三羟基环己基-5-脱氧-2-O-(2-脱氧-2-甲胺基-Α-L-吡喃葡萄糖基)-3-C-甲酰-Β-L-来苏戊呋喃糖甙/Strepomycin sulfateUSP级，720IU/mg

USP，30mg/ml

K0059盐酸万古霉素/万古霉素盐酸盐/Vancomycin HC1USP级，900mcg/mg

K0060去甲基盐酸万古霉素/盐酸去甲万古霉素/Norvoncomycin hydrochlorideUSP级，900u/mg

K0061盐酸壮观霉素/盐酸大观霉素/奇霉素/奇放线菌素/放线壮观霉素/Spectinomycin HClUSP级，779u/mg

K0062乙酰水杨酸/阿司匹林/阿斯匹林/邻醋酸基苯甲酸/乙酰基柳酸/醋柳酸/邻乙酰基水杨酸/Acetylsalicylic acidBR，99%

K0063阿奇霉素/阿齐霉素/阿红霉素/阿奇红霉素/9-脱氧-9a-氮杂-9a-甲基-9a-红霉素A/阿泽红霉素/阿齐红霉素/AzithromycinBR，98%

K0065硝酸咪康唑/美康唑/霉可唑/密康唑/双氯苯咪唑/达克宁/(2,4-二氯苯基)-2-[(2,4-二氯苯基)甲氧基]乙基]-1H-咪唑硝酸盐/酶康唑/硝酸氯益康唑/Miconazole nitrateUSP级，98.5%

K0066盐酸强力霉素/盐酸脱氧土霉素/盐酸多西环素/6-甲基-4-(二甲氨基)-3,5,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺盐酸盐/Doxycycline HClACS级，95-102%

K0067苯唑西林钠/苯唑青霉素/苯唑西林/苯甲异噁唑青霉素钠/新青霉素Ⅱ/新青霉素/苯唑青/新青Ⅱ号/(2S,5R,6R)-3,3-二甲基-6-[(5-甲基-3-苯基-1,2-恶唑-4-甲酰)氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-羧酸钠盐/Oxacillin sodium saltUSP级，95%

K0068哌拉西林钠/哌氨苄青霉素钠/氧哌嗪青霉素钠/(2S,5R,6R)-3,3-二甲基-6-[(4-乙基-2,3-二氧代-1-哌嗪甲酰氨基)苯乙酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠盐/Piperacillin sodium salt生物技术级，770ug/mg

K0071萘啶酮酸/萘啶酸/1-乙基-7-甲基-4-酮-1,8-萘啶-3-羧酸/7-甲基-1-乙基-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸/Nalidixic acid高纯，98%

BR，1%

BR，0.4%

K0072依托红霉素/红霉素硫酸月桂酸酯/红霉素丙酸酯十二烷基硫酸盐/无味红霉素/Erythromycin estolateBR，600u/mg

K0073琥乙红霉素/红霉素琥珀酸乙酯/Erythromycin ethyl succinateBR，780μg/mg

K0074阿维菌素/阿佛曼菌素/阿佛菌素/白螨净/杀虫素/阿灵/辛阿乳油/阿巴美丁/Abamectin分析标准品，97%