臂板蛋白4C抗体

英文名称    Sema4C    

中文名称    臂板蛋白4C抗体    

别    名    Semaphorin 4C; Semaf; Semai; Semacl1; AI426163; mKIAA1739; Semaphorin F.FLJ20369; KIAA1739; M-SEMA-F; MGC126382; MGC126383; SEMACL1; SEMAI; SEM4C_HUMAN; M-SEMA-F; S4c; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C; SEMA4C; SEMACL1; SEMAF; SEMAI; Semaphorin-4C; UNQ5855/PRO34487.    

臂板蛋白4C抗体        

说 明 书    0.1ml  0.2ml      

研究领域    神经生物学  干细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    90kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Sema4C    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

臂板蛋白4C抗体 产品介绍    background:
Members of the semaphorin protein family are involved in axonal guidance during neural development. Semaphorin 5a is thought to have a bifunctional role in axon guidance, exerting both attractive and inhibitory effects on developing axons associated with limbic function. The thrombospondin repeats of Semaphorin 5a physically interact with both heparan sulfate proteoglycans and chondroitin sulfate proteoglycans, inducing attractive and inhibitory guidance cues, respectively. The biological responses to Semaphorin 5a are induced through binding to its high-affinity receptor, plexin B3, triggering intracellular signaling through Met.

Function:
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Subunit:
Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the semaphorin family. 
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 
Contains 1 PSI domain. 
Contains 1 Sema domain.

Gene ID:
54910

Database links:

Entrez Gene: 54910 Human

Omim: 604462 Human

SwissProt: Q9C0C4 Human

Unigene: 516220 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

臂板蛋白4C抗体 

hz-1170P FOS B  FosB抗原

hz-1188P FRA2/FOSL2(Fos related/like antigen 2)  FOS样抗原2

hz-2585P FOXF1(Forkhead box protein F1)  叉头蛋白F1抗原

hz-1775P FOXJ1/HFH-4 peptide  插头蛋白J1抗原

hz-1275P FoxP1(Forkhead box P1)  FoxP1（T细胞转录因子）抗原

hz-2687P FOXM1/HFH 11 peptide  插头蛋白M1抗原

hz-0886P Measles virus of fusion protein  麻疹病毒抗原（麻疹病毒融合蛋白）

hz-0895P FSH-R(Follicle-stimulating hormone receptor precursor)  促卵泡刺激素受体抗原

hz-1536P FSH(Follicle-stimulating hormone precursor)  促卵泡刺激素抗原

hz-1232P GABRA1(gamma-aminobutyric acid (GABA) A receptor, alpha 1)  γ1氨基丁酸A型受体α1抗原

hz-0533P GABAB1(GABAb Receptor 1)  g-氨基丁酸B1受体(多肽)

hz-1293P GABABR2/GB2(GABA B Receptor 2)  γ1氨基丁酸A型受体B2抗原

hz-1302P GAD-67 (glutamate decarboxylase 67)  谷氨酸脱羧酶-67抗原

hz-1361P GADD153(Growth arrest and DNA damage-inducible 153)  生长抑制DNA损伤基因153抗原

hz-1641P phospho GAP-43(pSer41)(phospho Growth associated protein 43 )  磷酸化神经生长相关蛋白43抗原

hz-0834P GAPDH  3-磷酸甘油醛脱氢酶(人)抗原

hz-2209P CXCR3/CD183 peptide  细胞表面趋化因子受体3抗原

hz-1452P GATA-3(GATA binding factor 3)  GATA结合蛋白3抗原

hz-1778P GATA-4(GATA binding factor 4)  GATA结合蛋白4抗原

hz-1250P Gax(growth arrest-specific homeobox)  生长终止特异性同源盒基因抗原

hz-1288P GDF8/MSTN(growth differntiation factor 8)  生长分化因子8抗原

hz-1024P GDNF (Glial cell line-derived neurotrphic factor)  胶质细胞源性神经营养因子抗原

hz-1160P Gelsolin  凝溶胶蛋白抗原

hz-0844P GFP  绿色荧光蛋白

hz-0890P GFP  绿色荧光蛋白

hz-1173P GITR (glucocorticoidinduced tumor necrosis factor receptor)  糖皮质激素诱导肿瘤坏死因子受体抗原

hz-1206P GLI1(GLI-Kruppel family mhzber 1)  下游转录因子Gli1蛋白抗原

hz-0933P GLP-1/KG-31(Glucagon-like peptide-1) peptide  胰高血糖素样肽-1（多肽）

hz-0085P GLP-1 peptide  胰高血糖素样肽-1（多肽）

hz-1559P GLP-1R peptide  胰高血糖素样肽-1受体多肽

hz-1207P GLUT3(Glucose transporter 3)  葡萄糖转运蛋白3抗原