宿主细胞因子Zhangfei抗体

英文名称    Zhangfei    

中文名称    宿主细胞因子Zhangfei抗体    

别    名    1110034C16Rik; 6330417B10Rik; AI225749; AI606244; CREB/ATF bZIP transcription factor; Crebzf; FLJ94018; HCF-binding transcription factor Zhangfei; Host cell factor-binding transcription factor Zhangfei; LAZip; LAZipII; SHP-interacting leucine zipper protein; SMILE; ZF; ZHANG_HUMAN.    

宿主细胞因子Zhangfei抗体    

说 明 书    0.2ml      

研究领域    转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Zhangfei    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

宿主细胞因子Zhangfei抗体    产品介绍    background:
Host cell factor (HCF) is a cellular cofactor required for the activation of VP16 which expresses the herpes simplex virus immediate early gene. V16 binds to HCF through a 4-amino acid motif similar to the HCF binding domain of the basic leucine-zipper proteins Luman and Zhangfei (ZF). Luman activates promoters containing cAMP or unfolded protein response elements (UPRE). Zhangfei suppresses the transcriptional activity of Luman, but requires HCF binding which may target Luman and Zhangfei to a common location. Sequence analysis predicts that the deduced 272-amino acid Zhangfei protein has a negatively charged N terminus, a leucine zipper of 6 heptad leucine repeats separated by a conserved 6-amino acid spacer, a basic domain, and a bZIP region. It is also presumed that the N-terminal acidic region of Zhangfei is an activation domain.

Function:
Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.

Subcellular Location:
Nucleus. Colocalizes at punctate nuclear structures with CREB3 and HCFC1.

Tissue Specificity:
In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.

Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.

Gene ID:
58487

Database links:

Entrez Gene: 58487 Human

Entrez Gene: 233490 Mouse

Entrez Gene: 293112 Rat

Omim: 606444 Human

SwissProt: Q9NS37 Human

SwissProt: Q91ZR3 Mouse

Unigene: 535319 Human

Unigene: 714910 Human

Unigene: 29496 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

宿主细胞因子Zhangfei抗体    

hz-2353P Mast Cell Chymase  肥大细胞类糜蛋白酶1

hz-2373P Ceruloplasmin peptide  铜蓝蛋白抗原

hz-2394P CKLF1  趋化素样蛋白

hz-0055P ART(Arthzin)(抗原)  

hz-1510P AATK peptide  细胞凋亡关联酪氨酸激酶抗原

hz-0261P AQP-2 (aquaporin Protein-2)  水通道蛋白-2（抗原）

hz-1627P ABCA1(ATP binding cassette transporter A1)  腺苷三磷酸结合盒转运体A1抗原

hz-2535P TFPI/LACI  组织因子途径抑制剂

hz-2540P GLUT12  葡萄糖转运蛋白12

hz-2558P EGFRvIII  表皮生长因子受体III型突变体抗原

hz-2570P CD26  CD26抗原

hz-1231P ABCG1 peptide  三磷酸腺苷结合盒亚家族G1抗原

hz-2804P Cardiac Troponin T  心肌特异性肌钙蛋白T

hz-0164P BACE( ASP2 )   β分泌酶（抗原）

hz-0583P ABL1(v-abl Abelson murine leukhzia viral oncogene homolog 1)  ABL1抗原

hz-2940P FUCA1/Alpha L fucosidase I peptide  α-L岩藻糖苷酶抗原

hz-0295P-AF647 Rabbit IgG/Alexa Fluor 647  Alexa Fluor 647标记兔IgG(细胞流式同型对照)

hz-0275P Bassoon(BSN)  

hz-0127P Bax peptide  Bax（多肽抗原）

hz-0409P-FIThz Leptin peptide/FITC  荧光素FITC标记瘦素抗原

hz-0032P Bcl-2(抗原)  Bcl-2（多肽抗原）

hz-0248P BDNF (Brain-derived Neurotrophin factor)  脑源神经营养因子(脑衍化神经营养因子)（多肽片断抗原）

hz-2249P ACA11 peptide  拟南芥ACA11蛋白多肽抗原

hz-2247P AHA3 peptide  植物蛋白AHA3抗原（拟南芥）

hz-0217P bFGF  碱性成纤维细胞生长因子（多肽抗原）

hz-1004P ACE2(Angiotensin converting enzyme 2)  血管紧张素转换酶2抗原

hz-0044P BNP  脑钠素（多肽抗原）

hzb-0044P BNP/Biotin  生物素化脑钠素多肽

hz-0489P BrdU (Bromodeoxyuridine)  溴脱氧尿苷

hz-0324P C5  过敏毒素C5（补体C5）抗原

hz-0091P CA125  卵巢癌抗原

hz-2190P CK19  细胞角蛋白19抗原

hz-0043P CAD(Caspase-Activated Deoxyribonuclease)  Caspase 激活的脱氧核糖核酸酶（抗原）

hz-3550P MYOG  肌红蛋白抗原

hz-0095P Calponin 1  钙调节蛋白-1（抗原）

hz-3679P COMP  软骨寡聚基质蛋白抗原