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一键询价英文名称 SOD2
中文名称 超氧化物歧化酶2抗体
别 名 IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; SOD2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN.
超氧化物歧化酶2抗体
说 明 书 0.1ml 0.2ml 1ml
研究领域 神经生物学 细胞凋亡 激酶和磷酸酶 线粒体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
细胞定位 细胞浆 线粒体
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SOD2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
超氧化物歧化酶2抗体产品介绍 background:
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function:
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Subunit:
Homotetramer.
Subcellular Location:
Mitochondrion matrix.
Post-translational modifications:
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting.
DISEASE:
Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Similarity:
Belongs to the iron/manganese superoxide dismutase family.
Gene ID:
6648
Database links:
Entrez Gene: 374042 Chicken
Entrez Gene: 281496 Cow
Entrez Gene: 476258 Dog
Entrez Gene: 6648 Human
Entrez Gene: 20656 Mouse
Entrez Gene: 100154319 Pig
Entrez Gene: 24787 Rat
Omim: 147460 Human
SwissProt: P41976 Cow
SwissProt: P04179 Human
SwissProt: P09671 Mouse
SwissProt: P41982 Rabbit
SwissProt: P07895 Rat
Unigene: 487046 Human
Unigene: 290876 Mouse
Unigene: 10488 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
超氧化物歧化酶2抗体
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hz-0358M-AF555 Mouse Anti-Guinea pig IgG/Alexa Fluor 555 Alexa Fluor 555标记的小鼠抗豚鼠IgG
hz-0358M-AF647 Mouse Anti-Guinea pig IgG/Alexa Fluor 647 Alexa Fluor 647标记的小鼠抗豚鼠IgG
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hz-0312R-hzy5.5 Rabbit Anti-Avidin/Cy5.5 Cy5.5标记的兔抗亲和素
hz-0312R-Bio Rabbit Anti-Avidin/Bio 生物素标记的兔抗亲和素
hz-0312R-AP Rabbit Anti-Avidin/AP 碱性磷酸酶(AP)标记的兔抗亲和素
hz-0312R-HRP Rabbit Anti-Avidin/HRP 辣根过氧化物酶标记的兔抗亲和素
hz-0312R-hzy7 Rabbit Anti-Avidin/Cy7 Cy7标记的兔抗亲和素
hz-0312R-PE Rabbit Anti-Avidin/PE PE标记的兔抗亲和素
hz-0312R-PE-hzy3 Rabbit Anti-Avidin/PE-Cy3 PE-Cy3标记的兔抗亲和素
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hz-0312R-Gold Rabbit Anti-Avidin/Gold 胶体金标记的兔抗亲和素
hz-0312R-FIThz Rabbit Anti-Avidin/FITC FITC标记的兔抗亲和素
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hz-0312R-APhz Rabbit Anti-Avidin/APC APC标记的兔抗亲和素
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