细胞因子信号传导抑制蛋白1抗体

英文名称    SOCS1    

中文名称    细胞因子信号传导抑制蛋白1抗体    

别    名    CISH 1; CISH1; Cytokine Inducible SH2 Protein 1; JAB; JAK Binding Protein; Janus kinase binding protein; SOCS 1; SOCS1; SOCS-1; SSI 1; SSI1; STAT Induced STAT Inhibitor 1; Supressor of cytokine Signalling 1; TEC Interacting Protein 3; TIP 3; TIP3; SOCS1_HUMAN.    

细胞因子信号传导抑制蛋白1抗体 

说 明 书    0.1ml  0.2ml  1ml    

研究领域    细胞生物  神经生物学  信号转导  细胞凋亡  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Socs 1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

细胞因子信号传导抑制蛋白1抗体 产品介绍    background:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. High expression in thymus. Lower expression in lung and spleen.

Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Subunit:
Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with AXL, CUL2 and FGFR3. Interacts with INSR.

Subcellular Location:
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Tissue Specificity:
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Similarity:
Contains 1 SH2 domain. Contains 1 SOCS box domain.

Gene ID:
8651

Database links:

Entrez Gene: 8651 Human

Entrez Gene: 12703 Mouse

Entrez Gene: 252971 Rat

Omim: 603597 Human

SwissProt: O15524 Human

SwissProt: O35716 Mouse

SwissProt: Q9QX78 Rat

Unigene: 50640 Human

Unigene: 130 Mouse

Unigene: 82754 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

细胞因子信号传导抑制蛋白1抗体 

hz-0294M-AF488 Mouse Anti-Goat IgG/Alexa Fluor 488  Alexa Fluor 488标记的小鼠抗羊IgG

hz-0294M-AF555 Mouse Anti-Goat IgG/Alexa Fluor 555  Alexa Fluor 555标记的小鼠抗羊IgG

hz-0294M-AF647 Mouse Anti-Goat IgG/Alexa Fluor 647  Alexa Fluor 647标记的小鼠抗羊IgG

hz-0294M-PE-hzy5.5 Mouse Anti-Goat IgG/PE-Cy5.5  PE-Cy5.5标记的小鼠抗羊IgG

hz-0294M-PE-hzy7 Mouse Anti-Goat IgG/PE-Cy7  PE-Cy7标记的小鼠抗羊IgG

hz-0294M-AP Mouse Anti-Goat IgG/AP  碱性磷酸酶（AP）标记的小鼠抗羊IgG

hz-0294M-FIThz Mouse Anti-Goat IgG/FITC  FITC标记的小鼠抗羊IgG

hz-0295M-FIThz Mouse Anti-rabbit IgG/FITC  FITC标记的小鼠抗兔IgG

hz-0295M-RBIThz Mouse Anti-rabbit IgG/RBITC  罗丹明标记的小鼠抗兔IgG

hz-0295M-Gold Mouse Anti-rabbit IgG/Gold  胶体金标记的小鼠抗兔IgG

hz-0295M-AP Mouse Anti-rabbit IgG/AP  碱性磷酸酶（AP）标记的小鼠抗兔IgG

hz-0295M-Bio Mouse Anti-rabbit IgG/Bio  生物素标记的小鼠抗兔IgG

hz-0295M-hzy3 Mouse Anti-rabbit IgG/Cy3  Cy3标记的小鼠抗兔IgG

hz-0295M-hzy5 Mouse Anti-rabbit IgG/Cy5  Cy5标记的小鼠抗兔IgG

hz-0295M-hzy5.5 Mouse Anti-rabbit IgG/Cy5.5  Cy5.5标记的小鼠抗兔IgG

hz-0295M-hzy7 Mouse Anti-rabbit IgG/Cy7  Cy7标记的小鼠抗兔IgG

hz-0295M-PE Mouse Anti-rabbit IgG/PE  PE标记的小鼠抗兔IgG

hz-0295M-PE-hzy3 Mouse Anti-rabbit IgG/PE-Cy3  PE-Cy3标记的小鼠抗兔IgG

hz-0295M-PE-hzY5 Mouse Anti-rabbit IgG/PE-CY5  PE-CY5标记的小鼠抗兔IgG

hz-0295M-APhz Mouse Anti-rabbit IgG/APC  APC标记的小鼠抗兔IgG

hz-0295M-AF555 Mouse Anti-rabbit IgG/Alexa Fluor 555  Alexa Fluor 555标记的小鼠抗兔IgG

hz-0295M-AF647 Mouse Anti-rabbit IgG/Alexa Fluor 647  Alexa Fluor 647标记的小鼠抗兔IgG

hz-0295M-PE-hzy5.5 Mouse Anti-rabbit IgG/PE-Cy5.5  PE-Cy5.5标记的小鼠抗兔IgG

hz-0295M-PE-hzy7 Mouse Anti-rabbit IgG/PE-Cy7  PE-Cy7标记的小鼠抗兔IgG

hz-0295M-AF350 Mouse Anti-rabbit IgG/Alexa Fluor 350  Alexa Fluor 350标记的小鼠抗兔IgG

hz-0295M-AF488 Mouse Anti-rabbit IgG/Alexa Fluor 488  Alexa Fluor 488标记的小鼠抗兔IgG

hz-0295M-HRP Mouse Anti-rabbit IgG/HRP  辣根过氧化物酶标记的小鼠抗兔IgG

hz-0369M-Bio Mouse Anti-Rabbit IgM/Bio  生物素标记的小鼠抗兔IgM