垂体肿瘤转化基因抗体

英文名称    Securin    

中文名称    垂体肿瘤转化基因抗体    

别    名    AW555095; C87862; Cut2; EAP 1; EAP1; ESP1 ASSOCIATED PROTEIN 1; Esp1-associated protein; hPTTG; MGC126883; MGC138276; Pds1; Pituitary tumor transforming 1; Pituitary tumor transforming protein 1; Pituitary tumor-transforming 1, isoform CRA_a; Pituitary tumor-transforming 1, isoform CRA_b; Pituitary tumor-transforming gene 1; Pituitary tumor-transforming gene 1 protein; PTTG 1; PTTG; PTTG1; PTTG1 protein; PTTG1_HUMAN; Pttg3; Securin; TUMOR TRANSFORMING 1; Tumor transforming protein 1; TUMOR-TRANSFORMING 1; Tumor-transforming protein 1; TUTR 1; TUTR1.    

垂体肿瘤转化基因抗体    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  细胞周期蛋白  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    22-28kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PTTG1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

垂体肿瘤转化基因抗体    产品介绍    background:
The encoded protein is a homolog of yeast securing proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].

Function:
Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.

Subcellular Location:
Cytoplasm. Nucleus.

Post-translational modifications:
Phosphorylated at Ser-165 by CDK1 during mitosis.
Phosphorylated in vitro by ds-DNA kinase.
Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.

Similarity:
Belongs to the securin family.

Gene ID:
9232

Database links:

Entrez Gene: 9232 Human

Entrez Gene: 30939 Mouse

Entrez Gene: 64193 Rat

Omim: 604147 Human

SwissProt: O95997 Human

SwissProt: Q6IAL9 Human

SwissProt: Q3Y5K4 Mouse

SwissProt: Q5SRU0 Mouse

SwissProt: Q9CQJ7 Mouse

SwissProt: P97613 Rat

Unigene: 350966 Human

Unigene: 6856 Mouse

Unigene: 137183 Rat

Unigene: 271 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

垂体肿瘤转化基因抗体    

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hz-2400R NFBD1/MDC1  DNA损伤关卡蛋白1抗体

hz-0708R NF-H/Neurofilament H/Neurofilament 200  高分子量神经丝蛋白抗体

hz-3622R NFKB p52/NFKB2  细胞核因子/k基因结合核因子 p52/p100抗体

hz-3723R Phospho-NFKB2(Ser866+Ser870)  细胞核因子/k基因结合核因子p100抗体

hz-0465R NFKB p65  细胞核因子/k基因结合核因子抗体

hz-3543R Phospho-NFKB p65(Ser276)  磷酸化细胞核因子NF-κB p65抗体

hz-3485R Phospho-NFKB p65(Ser468)  磷酸化细胞核因子NF-κB p65抗体

hz-0982R phospho-NFKB p65(Ser536)  磷酸化细胞核因子抗体

hz-5660R phospho-NFKB p65(Ser529)  磷酸化细胞核因子抗体

hz-5661R phospho-NFKB p65(Thr435)  磷酸化细胞核因子抗体

hz-5662R phospho-NFKB p65(Thr254)  磷酸化细胞核因子抗体

hz-5663R phospho-NFKB p65(Thr505)  磷酸化细胞核因子抗体

hz-5664R SULT2A1  胆盐磺基转移酶

hz-4181R p53R2/RRM2B  核苷酸还原酶M2B抗体

hz-2408R NF66/alpha Internexin  α-中连蛋白抗体

hz-0707R NF-L/Neurofilament L/Neurofilament 68  低分子量神经丝蛋白抗体

hz-0710R NF-M/Neurofilament M  中分子量神经丝蛋白抗体

hz-1373R NGAL/Lipocalin 2  脂质运载蛋白抗体

hz-1194R NFkB p105/p50  细胞核因子p50/k基因结合核因子抗体

hz-3300R Phospho-NFκB-p105/p50(Ser927)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-3544R Phospho-NFKB1(Ser933)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5509R Phospho-NFKB1(Ser903)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5510R Phospho-NFKB1(Thr932)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5511R Phospho-NFKB1(Ser907)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5512R Phospho-NFKB1(Ser338)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5513R Phospho-NFKB1(Ser893)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-6205R NFkB p100/p52  细胞核因子p100/p52k基因结合核因子抗体

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