获取电话英文名称 SUR1
中文名称 磺酰脲类药物受体1抗体
别 名 ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.
磺酰脲类药物受体1抗体
说 明 书 0.1ml 0.2ml
研究领域 免疫学 细胞膜受体 药物及化合物 糖尿病 内分泌病
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Guinea Pig,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 175kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SUR1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
磺酰脲类药物受体1抗体产品介绍 background:
SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.
Subunit:
Interacts with KCNJ11.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磺酰脲类药物受体1抗体
hz-5070R HMGCS2 三羟基三甲基辅酶A合成酶2抗体
hz-1405R HNF1/TCF1/HNF1A 肝细胞核因子1α抗体
hz-3828R HNF4/TCF4/HNF4A 肝细胞核因子4α抗体
hz-4001R phospho-HNF4 (Ser313) 磷酸化肝细胞核因子4α抗体
hz-0827R HO-1 血红素氧合酶 1/热休克蛋白32抗体
hz-2075R Hhze Oxygenase 1/HO-1 血红素氧合酶 1/热休克蛋白32抗体
hz-1238R HO-2 血红素氧合酶2抗体
hz-3650R HOXB4 HOXB4抗体
hz-0394R HOXc8 HOXc8抗体
hz-2561R PSGD/HOXB13 同源盒蛋白HOXB13抗体
hz-1541R Heparanase 乙酰肝素酶抗体
hz-0928R phospho-HP1 alpha (Tyr24) 磷酸化异染色质蛋白1抗体（果蝇）
hz-2502R HOXA10 HOXA10抗体
hz-0930R Phospho-HP1(Tyr43) 异染色质蛋白1磷酸化抗体（果蝇）
hz-4046R HPCL2 植烷酰辅酶A羟化酶2抗体
hz-2902R HPL/PL 人胎盘泌乳素抗体
hz-2448R Nuclear Matrix Protein p84/NMP84 核基质p84蛋白抗体
hz-0990R HPV16-E6 人类乳头状瘤病毒16抗体
hz-0991R HPV18 E6 人类乳头状瘤病毒18 E6抗体
hzm-0991M HPV18 E6 monoclonal 人类乳头状瘤病毒18 E6单克隆抗体
hz-1719R HPV16 E6 + HPV18 E6 人类乳头状瘤病毒16/18 E6抗体
hz-0992R HPV16-E7 人类乳头状瘤病毒16-E7抗体
hz-2212R rHPV 重组人乳头瘤病毒抗体
hz-4623R HPV16-E7 人类乳头状瘤病毒16-E7抗体
hz-1808R Hpt/Haptoglobin 结合珠蛋白/触珠蛋白抗体
hz-1071R HRAS/Ras/Ras p21 原癌基因H-ras抗体
hz-6165R HRAS+KRAS 转化蛋白p21抗体（原癌基因H-ras抗体）
hz-1814R HRG-alpha/Neuregulin 1 Heregulin α蛋白抗体
hz-0945R albumin/AFM 人血清白蛋白抗体
hzm-0945M Albumin(3F4) 人血清白蛋白单克隆抗体
hz-1817R HRG Beta1 Heregulin β蛋白抗体