获取电话英文名称 Seladin 1
中文名称 24脱氢胆固醇还原酶抗体
别 名 Seladin1; Seladin-1; DHCR24; 24 dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; Desmosterol to cholesterol enzyme; Diminuto dwarf1 homolog; SELADIN1; Selective AD indicator 1; Selective Alzheimer's Disease Indicator 1.
24脱氢胆固醇还原酶抗体
说 明 书 0.2ml
研究领域 肿瘤 免疫学 神经生物学 信号转导 细胞凋亡 转录调节因子 Alzheimer's
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55/110kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Seladin 1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
24脱氢胆固醇还原酶抗体 产品介绍 background:
Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone).
Subunit:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue Specificity:
Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
Similarity:
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Contains 1 FAD-binding PCMH-type domain.
Database links:
Entrez Gene: 1718 Human
Entrez Gene: 74754 Mouse
Entrez Gene: 298298 Rat
Omim: 606418 Human
SwissProt: Q15392 Human
SwissProt: Q8VCH6 Mouse
SwissProt: Q5BQE6 Rat
Unigene: 498727 Human
Unigene: 133370 Mouse
Unigene: 225146 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
24脱氢胆固醇还原酶抗体
hz-6299R PRUNE/DRES17 乳腺癌相关蛋白DRES17抗体
hz-6300R Thz7R/Plxdc2 肿瘤血管内皮标记相关蛋白质7抗体
hz-5156R phospho-LSP1 (Ser252) 磷酸化白细胞F肌动蛋白结合蛋白抗体
hz-6301R MAP3K2/MEKK2 丝裂原活化蛋白激酶激酶2抗体
hz-6304R IFNA4/IFNA76/IFNA M1 干扰素α4抗体
hz-6305R Ryanodine Receptor 心肌兰尼碱受体抗体（脑肌兰尼碱受体）
hz-6306R GCMA/GCM1 绒毛膜特异性转录因子GCMa抗体
hz-6307R Desmocollin 1 桥粒糖蛋白1抗体
hz-6308R UACA 葡萄膜自身抗原Uaca抗体
hz-6309R IL-6 白介素6抗体
hz-6310R Caveolin-2 细胞质膜微囊蛋白-2抗体
hzm-1621M AFP(A2) 甲胎蛋白单克隆抗体（包被）
hzm-1622M AFP(A4) 甲胎蛋白单克隆抗体(检测)
hz-6311R BSCL2/SPG17 先天性脂肪代谢障碍蛋白2抗体（常染色体显性遗传痉挛性截瘫17）
hz-6312R IL-6 白介素6抗体
hz-6313R 4 Hydroxynonenal 4羟基壬烯酸抗体
hz-6314R NANOS2 生殖细胞增殖相关蛋白NANOS2抗体
hz-6315R CTBP2 C末端结合蛋白2抗体
hz-6316R PTGER1 前列腺素EP1受体抗体
hz-6317R phospho-PLB/phospholamban(phospho Ser16+Thr17) 磷酸化心脏磷蛋白抗体
hz-6318R ASM/Acid sphingomyelinase 酸性神经鞘磷脂酶抗体
hz-6319R IL-1 Beta/IL-1B 白介素1β抗体
hz-6320R BFAR/RNF47 环指蛋白47抗体
hz-6321R WISP1 Wnt1信号通路蛋白1抗体
hz-6322R Annexin A8 膜粘连蛋白8抗体
hz-6323R CD105/Endoglin CD105抗体
hz-6325R GLUT10/Glucose Transporter GLUT10 葡萄糖转运蛋白10抗体
hz-6326R CD54/ICAM-1 细胞间粘附分子1抗体
hz-6327R Filaggrin 兜甲蛋白抗体
hz-6329R Sortilin/NTR3/Gp95 神经降压素受体3抗体（糖蛋白95）
hz-6330R IFNA16/Interferon alpha 16 干扰素α16抗体
hz-6331R NET1 去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体
hz-6332R ABCA2 三磷酸腺苷结合盒转运蛋白2抗体
hz-6333R ApoB/Apolipoprotein B 载脂蛋白B抗体
hz-6334R ORP8 氧化固醇结合蛋白8抗体
hz-6335R ALOX15B/15 Lipoxygenase 2 花生四烯酸15脂氧合酶2抗体
hz-6336R APOB48R 载脂蛋白B受体抗体