获取电话英文名称 Scavenger Receptor BII
中文名称 清道夫受体B2抗体
别 名 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B member 2; AMRF; CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II); CD36 antigen; CD36 antigen-like 2; CD36L2; EPM4; HLGP85; LGP85; LIMP 2; LIMP II; LIMP2; LIMPII; Lysosomal integral membrane protein II; Lysosome membrane protein 2; Lysosome membrane protein II; OTTHUMP00000160590; OTTHUMP00000219176; Scarb2; Scavenger receptor class B member 2; Scavenger receptor class B, member 2; SCRB2_HUMAN; SR BII; SRBII.
清道夫受体B2抗体
说 明 书 0.2ml
研究领域 肿瘤 心血管 细胞生物 信号转导 转录调节因子 细胞膜受体
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Scavenger Receptor BII
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
清道夫受体B2抗体 产品介绍 background:
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
Function:
Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.
Subunit:
Interacts with GBA (via the coiled-coil domain).
Subcellular Location:
Lysosome membrane; Multi-pass membrane protein.
DISEASE:
Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4) [MIM:254900]. An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved.
Note=Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease.
Similarity:
Belongs to the CD36 family.
Database links:
Entrez Gene: 950 Human
Entrez Gene: 12492 Mouse
Entrez Gene: 117106 Rat
Omim: 602257 Human
SwissProt: Q14108 Human
SwissProt: O35114 Mouse
SwissProt: P27615 Rat
Unigene: 349656 Human
Unigene: 297964 Mouse
Unigene: 3957 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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