内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体

英文名称    SERPINA12    

中文名称    内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体    

别    名    OL 64; OL-64; OL64; Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 12 ; Serpin A12; Serpin A12 precursor; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 12; Serpina12; SPA12_HUMAN antibody Vaspin; Visceral adipose specific serpin; Visceral adipose tissue derived serine protease inhibitor; Visceral adipose tissue-derived serine protease inhibitor; Visceral adipose-specific serpin.    

内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体        

说 明 书    0.2ml      

研究领域    心血管  细胞生物  免疫学  神经生物学  信号转导  糖尿病      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    45kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SERPINA12/Vaspin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体 产品介绍    background:
May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues.
Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and tumor suppressor genes (maspin). Most inhibitory serpins target chymotrypsin-like serine proteases. These enzymes are defined by the presence of a nucleophilic serine residue in their catalytic site. Some serpins inhibit other classes of protease. A number of such serpins have been shown to target cysteine proteases. These enzymes differ from serine proteases in that they are defined by the presence of a nucleophilic cysteine residue, rather than a serine residue, in their catalytic site.
SerpinA12, also known as OL-64, Visceral adipose tissue-derived serine protease inhibitor, Vaspin, Visceral adipose-specific serpin and SERPINA12, is a secreted protein which belongs to the serpin family. SerpinA12 / Vaspin is expressed in visceral adipose tissues. It may modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. SerpinA12 / Vaspin may be the compensatory molecule in the pathogenesis of metabolic syndrome and SerpinA12 / Vaspin recombinant protein or vaspin-mimicking agents such as vaspin analogs, antibodies or small molecule agents may be the link to drug discovery and development.

Function:
May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in visceral adipose tissues.

Similarity:
Belongs to the serpin family.

Database links:
 

UniProtKB/Swiss-Prot: Q8IW75.1

Entrez Gene: 145264 Human

SwissProt: Q8IW75 Human

Unigene: 99476 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

内脏脂肪组织源性丝氨酸蛋白酶抑制蛋白抗体 

hz-8300R PRDX2/Peroxiredoxin-SO3  硫氧还蛋白过氧化物酶2

hz-8301R NDUFA9  NDUFA9蛋白抗体

hz-8302R GLT8D2  糖基转移酶GLT8D2抗体

hz-8303R LGI4  含亮氨酸神经胶质瘤失活蛋白4抗体

hz-8304R MTGR1  髓易位基因相关蛋白1抗体

hz-8305R LYL1  淋巴细胞性白血病相关序列1抗体

hz-8306R Properdin  P因子/备解素抗体

hz-8307R RAB6B  RAS癌基因相关蛋白RAB6B抗体

hz-8309R ANKRD54  锚蛋白重复域54抗体

hz-8310R COX4NB  COX4NB蛋白抗体

hz-8312R FAM82A1  微管动力调节蛋白FAM82A抗体

hz-8313R FAM46D/CT112  肿瘤/睾丸抗原112抗体

hz-8314R FAM50B  FAM50B蛋白抗体

hz-8315R FAM50C  FAM50C蛋白抗体

hz-8316R HDHD1  HDHD1蛋白抗体

hz-8317R HDHD2/IER3IP1  HDHD2蛋白抗体

hz-8318R HDHD3  HDHD3蛋白抗体

hz-8319R HDHD2B/LHPP  HDHD2B蛋白抗体

hz-8320R HEATR3  HEATR3蛋白抗体

hz-8321R HEATR6  乳腺癌增强蛋白抗体

hz-8322R Proteasome 19S S5A  26S蛋白酶调节亚型S5a抗体

hz-8324R Headpin/SERPINB13  丝氨酸蛋白酶抑制剂13抗体

hz-8325R SESN1/PA26  p53调控PA26核蛋白抗体

hz-8326R SESN2/Hi95  缺氧诱导基因95抗体

hz-8327R SLU7  SLU7蛋白抗体

hz-8328R SMEK2/PP4R3B  丝氨酸/苏氨酸蛋白磷酸酶3B抗体

hz-8329R SRXN1  硫氧还蛋白1抗体

hz-8330R STK25/YSK1  丝氨酸/苏氨酸激酶25抗体

hz-5378R PLCZ1  磷酸肌醇磷脂酶PLCZ1抗体

hz-4151R PLDL1/PLCE  磷脂酶C1样蛋白抗体

hz-8331R CPXCR1  肿瘤/睾丸抗原77抗体

hz-5379R PLTP  磷脂转移蛋白抗体

hz-8332R TM9SF4  跨膜蛋白9家族成员4抗体

hz-8333R RDH13  视黄醇脱氢酶13抗体

hz-8334R NIMP/RTN4IP1  NOGO相互作用线粒体蛋白1抗体