信号转导衔接蛋白1抗体

英文名称    STAM    

中文名称    信号转导衔接蛋白1抗体    

别    名    Signal transducing adapter molecule 1; Signal transducing adapter molecule 2; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; Signal transducing adaptor molecule; STAM 1; STAM-2; STAM1; Stam2; STAM2_HUMAN; DKFZp686J2352; Hrs-binding protein; HSE1 homolog; OTTHUMP00000019237.    

信号转导衔接蛋白1抗体        

说 明 书    0.2ml      

研究领域    细胞生物  信号转导  细胞周期蛋白  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    59kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human STAM    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号转导衔接蛋白1抗体    产品介绍    background:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Function:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Subunit:
Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Probably part of a complex at least composed of HSG, STAM and EPS15. Interacts with STAMBP/AMSH. Interacts with PDGFRB.

Subcellular Location:
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. 

Similarity:
Belongs to the STAM family. 
Contains 1 ITAM domain.
Contains 1 SH3 domain. 
Contains 1 UIM (ubiquitin-interacting motif) repeat.
Contains 1 VHS domain.

Gene ID:
10254

Database links:

Entrez Gene: 10254 Human

Entrez Gene: 8027 Human

Entrez Gene: 20844 Mouse

Entrez Gene: 56324 Mouse

Entrez Gene: 311030 Rat

Omim: 601899 Human

SwissProt: O75886 Human

SwissProt: Q92783 Human

SwissProt: O88811 Mouse

SwissProt: P70297 Mouse

SwissProt: Q5XHY7 Rat

Unigene: 17200 Human

Unigene: 263639 Mouse

Unigene: 161793 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

信号转导衔接蛋白1抗体    

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hz-7920R MAPK13/SAPK4/p38delta  丝裂原活化蛋白激酶13抗体

hz-7921R Robo2  轴突导向受体蛋白2抗体

hz-7922R SKAR  DNA聚合酶δ相互作用蛋白3抗体

hz-7923R SRPK2  丝氨酸/苏氨酸蛋白激酶SRPK2抗体

hz-7924R TBRG4  转化生长因子β调节蛋白4抗体

hz-7925R TLK2  丝氨酸/苏氨酸激酶TLK2抗体

hz-7926R ANKRD28  锚蛋白重复域28抗体

hz-7927R SIPA1L2  信号诱导增殖相关蛋白1样蛋白2抗体

hz-7928R DUSP7  双特异性蛋白磷酸酶7抗体

hz-7929R PPM1B  蛋白质磷酸酶1B抗体（PP2Cβ）

hz-7930R PPM1G  蛋白质磷酸酶1G抗体（PP2Cγ）

hz-7931R PPP2R1A  蛋白质磷酸酶2调节亚基1A抗体

hz-7932R PPP2R1B  蛋白质磷酸酶2调节亚基1B抗体

hz-7933R PPP2R3A  蛋白质磷酸酶2调节亚基3A抗体

hz-7934R SHOC2/Sur8  富含亮氨酸重复蛋白SHOC2抗体

hz-7935R RAMP/CDT2  维甲酸调节核基质相关蛋白

hz-7936R MTMR8  肌管素相关蛋白8抗体

hz-7937R NIFK  KI67相互作用蛋白抗体

hz-7938R phospho-NIFK/MKI67IP(Thr234)  磷酸化KI67相互作用蛋白抗体

hz-7939R TACC1  乳腺癌、胃癌抗原GA55抗体

hz-7941R ABCF3  三磷酸腺苷结合盒转运蛋白F亚基3抗体

hz-7942R ABHD1  肺α/β水解酶蛋白1抗体

hz-7943R ABHD13  水解酶结构域蛋白13抗体

hz-7945R ABHD14B  水解酶结构域蛋白14B抗体

hz-7946R ABHD15  水解酶结构域蛋白15抗体

hz-7947R ABHD3  肺α/β水解酶蛋白3抗体

hz-7948R ABHD4  α/β水解酶4抗体

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hz-7951R ADCK1  ADCK1蛋白抗体

hz-7952R ADCK2  ADCK2蛋白抗体