胆汁酸盐输出泵蛋白抗体

 胆汁酸盐输出泵蛋白抗体

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

 胆汁酸盐输出泵蛋白抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 胆汁酸盐输出泵蛋白抗体产品介绍

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. 

    Bile formation is an important function of the liver. It is mediated by hepatocytes which generate bile flow within the bile canaliculi by continuous vectorial secretion of bile salts and other solutes across their canalicular (apical) membrane. Bile secretion is mediated by several ATP-binding cassette (ABC) transporters located in the canalicular membrane of hepatocytes. Among these ABC transporters, ABCB11 (bile salt export pump or BSEP) represents the primary, if not sole transport system for the canalicular excretion of bile salts. Bile secretory failure results in cholestasis and progressive familial intrahepatic cholestasis (PFIC) in infancy represents a group of inherited cholestatic diseases that are classified into three subtypes. One of these subtypes, PFIC II, is associated with mutations in the ABCB11 gene. PFIC patients with mutations in the ABCB11 gene have normal serum gamma-glutamyltransferase activity, low concentrations of bile salts in bile, and an absence of bile duct proliferation. Additionally, human obesity is associated with altered cholesterol homeostasis including increased production and turnover, as well as secretion of excess cholesterol from the liver into bile. 
    ABCB11 is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane ancoring domain and an ATP binding cassette (ABC) domain. The membrane anchoring domain is composed of six helixes buried in the lipid bilayer of the plasma membrane and the ATP binding ABCs are exposed to the cytosol. The membrane anchoring domain helixes are thought to form channels spanning the plasma membrane. 
    mol wt:145kDa 
    Other Aliases: 
    Bile salt export pump; ATP binding cassette sub family B (MDR/TAP) member 11; ATP binding cassette sub family B member 11; Bsep; Sister of P glycoprotein; Spgp; Abcb11; ABC16; Lith1; PFIC2; PGY4

xy-1114R beta Adducin内收蛋白抗体

xy-1164R ADFP脂肪组织分化相关蛋白抗体

 胆汁酸盐输出泵蛋白抗体

xy-0610R Adiponectin Receptor 1脂联素受体1抗体

xy-0090R ADM R肾上腺髓质素受体抗体

xy-0471R Adiponectin脂联素抗体

xy-0007R ADM肾上腺髓质素抗体

xy-1225R Adenosine A3 Receptor腺苷受体A3抗体

xy-1062R ADRA2ADRA2肾上腺素能受体2抗体

xy-0498R ADRB1肾上腺素能受体β1抗体

xy-0947R ADRB2肾上腺素能受体β2/β2-AR抗体

xy-1158R AGEs晚期糖基化终末产物抗体

xy-1223R Aggrecan1软骨蛋白聚糖抗体

xy-9516R ALAS-E5-氨基乙酰丙酸合酶1抗体

xy-1282R ASPP1p53凋亡刺激蛋白1抗体

xy-1283R ASPP2P53凋亡刺激蛋白2抗体

xy-0801R ARIP2B激活素受体2B抗体

xy-2509R AIMP2AIMP2抗体

xy-2511R ACHE乙酰胆碱酶抗体

xy-9527R ALAS15-氨基乙酰丙酸合酶1抗体

xy-1697R alpha Defensin 1防御素α1/3抗体

xy-1727R ABCG4ABC膜转运蛋白抗体

xy-2221R ATEXPA10植物延长蛋白（拟南芥）

xy-2251R A RafA-Raf抗体

xy-3371R Phospho-A Raf(Ser299)磷酸化A-Raf抗体

xy-9517R AMPD3红细胞腺苷脱氨酶3抗体

xy-2410R ABP雄激素结合蛋白抗体

xy-1576R ALR肝再生增强因子抗体

xy-0112R Amyloid Precursor ProteinAPP/ABPP淀粉样肽前体蛋白抗体

xym-1621M AFP(A2)甲胎蛋白单克隆抗体（包被）

xym-1622M AFP(A4)甲胎蛋白单克隆抗体(检测)

xy-1477R ARFIP1 ADP核糖基化因子结合蛋白1抗体

xy-1416R AHR芳香烃受体抗体

xy-1528R ATRN吸引素抗体

xy-1627R ABCA1腺苷三磷酸结合盒转运体A1抗体

xy-2056R AKT2蛋白激酶B2

xy-0677R Angiopoietin 2血管生成素2抗体

xy-0114R Aromatase芳香化酶/细胞色素P450/雌激素合成酶抗体

xy-1456R Adenosine Receptor A2a腺苷A2A受体抗体

xy-1473R AKAP95蛋白激酶A锚定蛋白95抗体

xy-4189R ASBT顶膜钠依赖性胆盐转运体蛋白抗体

xy-4195R ADAM8去整合素样金属蛋白酶8抗体

xy-11386R AADACL3芳香乙酰胺脱乙酰基酶样蛋白3抗体

xy-12444R ACN9ACN9蛋白抗体

xy-2167R ADAR1 (N-terminus)双链RNA腺苷酸脱氨基酶抗体（N端）

xy-2771R AMPK alpha 2腺苷单磷酸活化蛋白激酶α2抗体

xy-2778R ADK腺苷酸激酶抗体

xy-13780R A2ML1α2巨球蛋白样蛋白1抗体 α2ML1

xy-13814R APR3细胞凋亡相关蛋白3抗体

xy-10196R Actin肌动蛋白α/α-SMA/α Actin抗体

xy-12331R ABCB7ATP结合蛋白家族7抗体

xy-12349R ASCL2ASCL2蛋白抗体

xy-12534R phospho-Ataxin 1(Ser775)磷酸化脊髓小脑失调症蛋白1抗体

xy-12535R phospho-ATF1 (Ser63)磷酸化活化转录因子1抗体

xy-12536R phospho-ATF2 (Ser480)磷酸化活化复制因子2抗体

xy-12537R phospho-ATF2 (Thr51 + Thr53)磷酸化活化复制因子2抗体

xy-12538R phospho-ATF2 (Thr69 + Thr51)磷酸化活化复制因子2抗体