基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体

基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体产品介绍

    MMP12可使为纤溶酶原转化为血管稳定因子(angiostatin),是一种重要的肿瘤血管形成的抑制因子。

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis, metastasis, and atherosclerosis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
    MMP12 was first described in murine macrophages, later in human macrophages, and more recently in other cell types. Also known as metalloelastase, MMP12 is able to degrade elastin, entactin, laminin 1, fibronectin, type IV collagen as well as insulin B-chain and casein. MMP12 is often confused with the Serine proteinase, Leukocyte elastase (EC 3.4.21.37) because of similar nomenclature. MMP12 is structurally similar to the classical MMPs (MMP1, MMP3); it contains a propeptide with autoinhibitory cysteine switch site, a well-conserved zinc site, hinge region and hemopexin domain. MMP12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kD, and is quickly activated to the 45 kD form; and this breaks down to cascade of active forms, ending with the common 22 kD form. Stimulated macrophages produce MMP12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts.
    mol wt:45kDa
    Other Aliases: 
    matrix metalloproteinase 12; EC 3.4.24.65; HME; Macrophage elastase; Macrophage metaloelastase; Matrix metalloprotease 12; ME; MGC138506; MME; MMP 12

xy-0374R-AF555 Rabbit Anti-horse IgM/Alexa Fluor 555Alexa Fluor 555标记的兔抗马IgM

xy-0374R-RBITxy Rabbit Anti-horse IgM/RBITC罗丹明标记的兔抗马IgM

xy-0374R-xyy3 Rabbit Anti-horse IgM/Cy3Cy3标记的兔抗马IgM

基质金属蛋白酶-12/巨噬细胞金属弹力蛋白酶抗体

xy-0374R-xyy5.5 Rabbit Anti-horse IgM/Cy5.5Cy5.5标记的兔抗马IgM

xy-0374R-xyy5 Rabbit Anti-horse IgM/Cy5Cy5标记的兔抗马IgM

xy-0374R-xyy7 Rabbit Anti-horse IgM/Cy7Cy7标记的兔抗马IgM

xy-0374R-xyE Rabbit Anti-horse IgM/PEPE标记的兔抗马IgM

xy-0374R-FITxy Rabbit Anti-horse IgM/FITCFITC标记的兔抗马IgM

xy-0374R-Bio Rabbit Anti-horse IgM/Bio生物素标记的兔抗马IgM

xy-0326G-xyy5 Goat Anti-Bovine IgG/Cy5Cy5标记的羊抗牛IgG

xy-0326G-Bio Goat Anti-Bovine IgG/Bio生物素标记的羊抗牛IgG

xy-0326G-FITxy Goat Anti-Bovine IgG/FITCFITC标记的羊抗牛IgG

xy-0326G-RBITxy Goat Anti-Bovine IgG/RBITC罗丹明标记的羊抗牛IgG

xy-0326G-xyE-xyy3 Goat Anti-Bovine IgG/PE-Cy3PE-Cy3标记的羊抗牛IgG

xy-0326G-xyE-xyY5 Goat Anti-Bovine IgG/PE-CY5PE-CY5标记的羊抗牛IgG

xy-0326G-Axyxy Goat Anti-Bovine IgG/APCAPC标记的羊抗牛IgG

xy-0326G-AF350 Goat Anti-Bovine IgG/Alexa Fluor 350Alexa Fluor 350标记的羊抗牛IgG

xy-0326G-AF488 Goat Anti-Bovine IgG/Alexa Fluor 488Alexa Fluor 488标记的羊抗牛IgG

xy-0326G-AF555 Goat Anti-Bovine IgG/Alexa Fluor 555Alexa Fluor 555标记的羊抗牛IgG

xy-0326G-AF647 Goat Anti-Bovine IgG/Alexa Fluor 647Alexa Fluor 647标记的羊抗牛IgG

xy-0326G-xyE-xyy5.5 Goat Anti-Bovine IgG/PE-Cy5.5PE-Cy5.5标记的羊抗牛IgG

xy-0326G-xyE-xyy7 Goat Anti-Bovine IgG/PE-Cy7PE-Cy7标记的羊抗牛IgG

xy-0326G-xyy7 Goat Anti-Bovine IgG/Cy7Cy7标记的羊抗牛IgG

xy-0326G-Axy Goat Anti-Bovine IgG/AP碱性磷酸酶（AP）标记的羊抗牛IgG

xy-0326G-Golxy Goat Anti-Bovine IgG/Gold胶体金标记的羊抗牛IgG

xy-0326G-xyy5.5 Goat Anti-Bovine IgG/Cy5.5Cy5.5标记的羊抗牛IgG

xy-0296G-Axy Goat Anti-Mouse IgG/AP碱性磷酸酶（AP）标记的羊抗小鼠IgG

xy-0296G-FITxy Goat Anti-Mouse IgG/FITCFITC标记的羊抗小鼠IgG

xy-0296G-xyE-xyy3 Goat Anti-Mouse IgG/PE-Cy3PE-Cy3标记的羊抗小鼠IgG

xy-0296G-xyy5 Goat Anti-Mouse IgG/Cy5Cy5标记的羊抗小鼠IgG

xy-0296G-xyy5.5 Goat Anti-Mouse IgG/Cy5.5Cy5.5标记的羊抗小鼠IgG

xy-0296G-xyy7 Goat Anti-Mouse IgG/Cy7Cy7标记的羊抗小鼠IgG

xy-0296G-Axyxy Goat Anti-Mouse IgG/APCAPC标记的羊抗小鼠IgG

xy-0296G-xyE-xyy5.5 Goat Anti-Mouse IgG/PE-Cy5.5PE-Cy5.5标记的羊抗小鼠IgG

xy-0368G-Bio Goat Anti-Mouse IgM/Bio生物素标记的羊抗小鼠IgM

xy-0368G-HRxy Goat Anti-Mouse IgM/HRP辣根过氧化物酶标记的羊抗小鼠IgM

xy-0368G-RBITxy Goat Anti-Mouse IgM/RBITC罗丹明标记的羊抗小鼠IgM