胰岛素样生长因子结合蛋白-1抗体

胰岛素样生长因子结合蛋白-1抗体

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

胰岛素样生长因子结合蛋白-1抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

胰岛素样生长因子结合蛋白-1抗体产品说明

    生长因子和激素（ Growth Factor and Hormones）
    胰岛素样生长因子结合蛋白1(IGFBP-2)是IGF/IGFBP家族中的一个重要成员,在多种疾病尤其是肿瘤中其表达明显增高,可能通过调节胰岛素样生长因子(insulin-like growth factor,IGF)发挥作用，促进肿瘤的发生发展。

    Insulin like growth factor binding protein 1 (IGFBP1) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The N terminal and C terminal regions are highly homologous among rat, human and bovine sequences. Contained within IGFBP1 and 2 is an integrin receptor recognition sequence (RGD) that is responsible for promoting cell migration by an IGF independent action. IGFBPs hold a central position in IGF ligand receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBPs will either inhibit or enhance the biological activities of IGF or act in an IGF independent manner. Post translational modification of IGFBPs, including phosphorylation and proteolysis, will modify the affinities of the binding proteins for IGF and may indirectly regulate IGF actions. IGFBP1 is expressed in liver, decidua, and kidneys and is the major IGF binding protein in human amnionic fluid. In hepatocytes, IGFBP1 production is regulated at the transcriptional level due to the effects of insulin and corticosteriods. IGFBP1 is the major determinant of the level of free IGF in serum. The expression of IGFBP1 is inhibited by insulin, IGFI, and IGFII and is stimulated by glucocorticoids, thyroid hormone, and epidermal growth factor (EGF), indicating an endocrine function. IGFBP1 shows inhibitory actions on cell proliferation and differentiation, presumably by interfering with the interactions between IGF and the IGF receptor (IGFR).
    mol wt:30kDa 
    Other Aliases: 
    Insulin-like Growth Factor Binding Protein 1; AFBP; Alpha pregnancy associated endometrial globulin; Amniotic fluid binding protein; Binding protein 25; Binding protein 26; Binding protein 28; Growth hormone independent binding protein; hIGFBP 1; hIGFBP1; IBP 1; IBP1; IGF binding protein 1; IGF BP25; IGFBP 1; Placental protein 12; PP12

xy-1138R Somatostatin Receptor 2生长抑素受体2抗体

胰岛素样生长因子结合蛋白-1抗体

xy-1139R Somatostatin Receptor 5生长抑素受体5抗体

xy-1136R synaptotagmin-2突触结合蛋白相关基因2抗体

xy-1140R STAT2信号转导和转录激活因子2抗体

xy-0276R SSB干燥症SSB/La抗体

xy-1133R SPARC富含半胱氨酸的酸性分泌蛋白抗体

xy-1141R STAT3信号转导和转录激活因子3抗体

xy-1142R STAT5信号转导和转录激活因子5抗体

xy-1143R STAT6信号转导和转录激活因子6抗体

xy-0685R SYK非受体型酪氨酸蛋白激酶抗体

xy-0679R SYVN1滑膜细胞凋亡抑制物1抗体

xy-0277R SELS炎症负调控因子蛋白抗体

xy-1278R 8-OHdG8-羟基脱氧鸟苷抗体

xy-0132R SARS putative orflab polyprotein冠状病毒抗体

xy-9514R PI14蛋白酶抑制剂14抗体

xy-4536R Streptococcus suis 22型猪链球菌菌体蛋白抗体

xy-1619R Smad1细胞信号转导分子Smad-1抗体

xy-3403R Phospho-SHP2 (Tyr542)磷酸化蛋白酪氨酸磷酸酶2抗体

xy-3405R Phospho-SHP2 (Tyr584)磷酸化蛋白酪氨酸磷酸酶2抗体

xy-3568R SMC1染色体结构维持蛋白1抗体

xy-3406R Phospho-SMC1 (Ser360)磷酸化染色体结构维持蛋白质１抗体

xy-3570R StAR促黄体激素诱导蛋白抗体

xy-5724R STK36丝氨酸/苏氨酸激酶36融合同源蛋白抗体

xy-6577R S100P binding proteinS100P结合蛋白抗体

xy-6578R SAMD14SAMD14抗体

xy-7506R SMOC2分泌模块化钙结合蛋白2抗体（平滑肌相关蛋白2）

xy-6787R SLC26A4钠碘单独转运蛋白SLC26A4抗体

xy-7507R Sprouty 2快速发育生长因子同源蛋白2抗体

xy-7078R SPNS1SPNS1抗体

xy-7519R SEMA4A跨膜蛋白SEMA4A抗体

xy-11362R SNAP23突触相关蛋白23抗体

xy-11361R SAP97突触相关蛋白97抗体

xy-11374R Synaptogyrin 2神经细胞囊泡循环蛋白2抗体

xy-11363R SNAP29突触相关蛋白29抗体

xy-11364R SNAPIN突触相关蛋白25结合蛋白抗体

xy-11365R SV2B突触泡蛋白2B抗体

xy-11366R SV2C突触泡蛋白2C抗体

xy-11367R SYNPR/Synaptoporin突触囊泡蛋白抗体

xy-11368R Sec8胞吐分泌蛋白Sec8抗体