抗磷酸化信号转导和转录激活因子3抗体

抗磷酸化信号转导和转录激活因子3抗体

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

 抗磷酸化信号转导和转录激活因子3抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 抗磷酸化信号转导和转录激活因子3抗体

产品介绍

    转录调节因子（Transcriptin Regulators） 

    STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5.
    Specific functions of the various members of the STAT family are poorly understood. STAT3 has been shown to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage. 
    STAT1 and STAT2 are induced by IFN alpha and forn 1, a heterodimer which is part of the ISGF transcription factor complex. The STAT3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFNa, IL10, IL6, IL11, IL12, IL2, EGF, among others. STAT3 beta appears to be activated by both EGF and IL6, but STAT3 alpha is only activated by EGF. STAT3 binds to DNA as either a homodimer or as a heterodimer with STAT1. STAT3 interacts with the APRE acute phase response element) and SIE (csis inducible element). STAT4, predominantly expressed in testis and myeloid cells, is activated by ILl2. STAT5 is activated by prolactin and IL3. STAT6 participates in signaling pathways mediated by IL4.

    Also known as: 
    Acute Phase Response Factor; APRF; DNA binding protein APRF; FLJ20882; MGC16063; Signal Transductor and Activator of Transcription 3; STAT 3

xy-0474R human Serum IgA人血清型免疫球蛋白A抗体

xy-7867R Iroquois homeobox protein 3Irx3蛋白抗体

抗磷酸化信号转导和转录激活因子3抗体

xy-7866R Intra Acrosomal Protein精子顶端体蛋白10抗体

xy-4964R human secretory IgA人分泌型免疫球蛋白A

xy-11349R ICA1胰岛细胞自身抗原1抗体

xy-11321R Islet 2胰岛素基因增强结合蛋白2抗体

xy-0768R IL-16白介素-16抗体

xy-1363R AIF1离子钙接头蛋白抗体

xy-9464R IRX4Iroquois同源蛋白4抗体

xy-6877R IFRD1干扰素相关发育调节蛋白1抗体（神经生长因子诱导蛋白PC4）

xy-6870R ILP2抑制细胞凋亡样蛋白2抗体

xy-4750R IFITM1干扰素诱导跨膜蛋白1抗体

xy-8690R IFI44干扰素诱导蛋白44抗体

xy-6471R ITPR35-三磷酸肌醇受体3抗体

xy-15525R IFNW1干扰素omega 1蛋白抗体

xy-15521R IFNA7干扰素alpha 7蛋白抗体

xy-0787R IFN-Beta干扰素β抗体

xy-3529R ID1DNA结合抑制因子1抗体

xy-8676R IFI-202γ干扰素诱导蛋白202抗体

xy-0788R intestinal FABP/IFABP/FABP2肠型脂肪酸结合蛋白抗体

xy-1291R ING1生长抑制因子基因1抗体

xy-0780R IL-8/CXCL8白介素8抗体

xy-0317R ILK-1整合素连接激酶-1抗体

xy-3235R phospho-IKK alpha (Ser176 + Ser180)磷酸化KB抑制蛋白激酶α抗体

xy-3236R Phospho-IKK alpha(Ser180) + IKK beta(Ser181)磷酸化KB抑制蛋白激酶α/β抗体

xy-3237R Phospho-IKK alpha/beta (Ser176 + Ser180)磷酸化KB抑制蛋白激酶α/β抗体

xy-15563R IFT46细胞纤毛内转运同源蛋白46抗体

xy-2459R IL-10RA白细胞介素-10受体a抗体

xy-2460R IL-13Ra1白细胞介素-13受体a1抗体

xy-4015R IRGM免疫相关鸟苷三磷酸酶基因抗体

xy-2461R IL-13Ra2白细胞介素-13受体a2抗体

xy-2450R I-309嗜酸粒细胞趋化蛋白CCL1抗体

xy-3226R phospho-IGF1R (Tyr1161)磷酸化胰岛素样生长因子1受体抗体

xy-0018R IDE胰岛素降解酶抗体

xy-1789R IL-12白介素12抗体

xy-1740R IL-4白介素4抗体

xy-6059R IGFBP9胰岛素样生长因子结合蛋白9抗体

xy-2710R IFNGR2干扰素-gamma受体2抗体

xy-2711R IL-27R白细胞介素27受体抗体

xy-2216R IL-1RA白介素-1受体拮抗剂抗体

xy-2898R IKK gammaKB抑制蛋白激酶γ抗体

xy-3227R phospho-IKK gamma (Ser85)磷酸化KB抑制蛋白激酶γ抗体

xy-3228R phospho-IKK gamma (Ser31)磷酸化KB抑制蛋白激酶γ抗体

xy-3229R Phospho-IKK alpha (Thr23)磷酸化KB抑制蛋白激酶α/IKK α 抗体

xy-3232R phospho-IKK beta(Tyr199)磷酸化KB抑制蛋白激酶β抗体

xy-3233R phospho-IKK beta(Tyr188)磷酸化KB抑制蛋白激酶β抗体

xy-3234R phospho-IKK alpha (Tyr463)磷酸化KB抑制蛋白激酶α抗体

xy-3230R phospho-IKK gamma (Ser376)磷酸化KB抑制蛋白激酶γ抗体

xy-3231R phospho-IKK beta(Ser466)磷酸化KB抑制蛋白激酶β抗体

xy-15552R IFI6干扰素alpha诱导蛋白6抗体

xy-2613R IL-17E/IL-25白介素-17E抗体

xy-2736R phospho-IRS-1(Ser307)磷酸化胰岛素受体底物p-IRS-1/2抗体

xy-15529R IARS2tRNA异亮氨酸连接酶抗体