信号肽肽酶SPP抗体

英文名称    Signal Peptide Peptidase    

中文名称    信号肽肽酶SPP抗体    

别    名    Histocompatibility (minor) 13; HM 13; HM13; HM13_HUMAN; IMP 1; IMP-1; IMP1; IMPAS; IMPAS-1; Intramembrane Protease 1; Intramembrane protease; Minor Histocompatibility 13; Minor histocompatibility antigen 13; Minor histocompatibility antigen H13; MSTP086; Presenilin like protein 3; Presenilin-like protein 3; PSENL 3; PSENL3; PSL 3; PSL3; Signal peptide peptidase; Signal peptide peptidase beta; SPP; dJ324O17.1; H13; hIMP1; hIMP1 protein.    

信号肽肽酶SPP抗体    

说 明 书    0.2ml      

研究领域    肿瘤  免疫学  神经生物学  信号转导      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    42kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Signal Peptide Peptidase    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号肽肽酶SPP抗体产品介绍    background:
The endoplasmic reticulum exerts a quality control over newly synthesized proteins and a variety of components have been implicated in the specific recognition of aberrant or misfolded polypeptides. Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. SPP is required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides, and may play a role in graft rejection. It also may be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein.

Function:
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Isoform 4: Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the peptidase A22B family.

Database links:

Entrez Gene: 81502 Human

Omim: 607106 Human

SwissProt: Q8TCT9 Human

Unigene: 373741 Human

Unigene: 444601 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

信号肽肽酶SPP抗体

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hz-3284R Phospho-MSK1(Thr581)  磷酸化有丝分裂原和应激活化型蛋白激酶1抗体

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hz-4634R Phospho-Mst2(Thr180)  磷酸化蛋白激酶MST2抗体

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hz-0836R MLH1/hMLH 1  错配修复蛋白1抗体

hz-0300R Mesothelin  间皮素抗体

hz-1022R MUC5AC/Mucin 5AC  胃粘液素抗体

hz-3601R MTF-1  金属应答元件结合转录因子-1抗体

hz-1484R MTHFR  亚甲基四氢叶酸还原酶MTHFR抗体

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hz-0963R MTNR1B  褪黑素受体1B抗体

hz-1445R MLN/Motilin  胃动素抗体

hz-1992R mTOR/FRAP  雷帕霉素靶蛋白抗体

hz-3494R Phospho-FRAP1/mTOR(Ser2448)  磷酸化雷帕霉素靶蛋白抗体

hz-3495R Phospho-mTOR (Ser2481)  磷酸化雷帕霉素靶蛋白抗体

hz-5329R Phospho-mTOR (Tyr144)  磷酸化雷帕霉素靶蛋白抗体

hz-5330R Phospho-RhoA(Ser188)  磷酸化RhoA蛋白抗体

hz-5331R Phospho-mTOR (Thr2446)   磷酸化雷帕霉素靶蛋白抗体

hz-1724R MTLR  胃动素受体抗体

hz-5083R MTTP  微粒体甘油三酯转运蛋白

hz-5085R MVD  甲羟戊酸脱羧酶抗体

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hz-1993R Muc2  粘蛋白-2/上皮膜抗原2抗体

hz-1525R mucin3/Muc3  粘蛋白-3抗体

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