双链RNA结合蛋白Staufen2抗体

英文名称    STAU2    

中文名称    双链RNA结合蛋白Staufen2抗体    

别    名    Double stranded RNA binding protein Staufen homolog 2; MGC119606; STAU 2; STAU2; STAU-2; Staufen (Drosophila, RNA-binding protein) homolog 2; Staufen homolog 2; Staufen RNA binding protein homolog 2; Staufen, RNA binding protein, homolog 2 (Drosophila); 39K2; 39K3; DKFZp781K0371; STAU2_HUMAN.    

  双链RNA结合蛋白Staufen2抗体    

说 明 书    0.2ml      

研究领域    神经生物学  细胞粘附分子  细胞骨架  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    63kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human STAU2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 双链RNA结合蛋白Staufen2抗体产品介绍    background:
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. 

Function:
RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity). 

Subunit:
Interacts with the exportin XPO5. This requires RNA and RAN bound to GTP. Interacts with microtubules. Isoform 2 and isoform 3 may also interact with ribosomes, and this association is independent of translation (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. 

Subcellular Location:
Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). 

Similarity:
Contains 4 DRBM (double-stranded RNA-binding) domains.

Database links:
UniProtKB/Swiss-Prot: Q9NUL3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 双链RNA结合蛋白Staufen2抗体

hz-1698R ox-LDL  氧化低密度脂蛋白抗体

hz-1810R LDHA/LDH  乳酸脱氢酶抗体

hz-3827R LDHC/Cancer,testis antigen 32  乳酸脱氢酶LDH-C（肿瘤/睾丸抗原32）抗体

hz-1582R Mannan Binding Lectin  甘露聚糖结合凝集素抗体

hz-1843R LEF-1  淋巴增强因子-1抗体

hz-3907R Legumain  半胱氨酸蛋白酶抗体

hz-0108R Leptin  瘦素抗体

hz-0409R Leptin  瘦素抗体

hz-4604R Leptin  瘦素抗体

hz-0410R Leptin receptor/Ob-R  瘦素受体抗体

hz-0109R Leptin receptor(long)  瘦素受体抗体（长）

hz-0961R Leptin receptor/OB-R  瘦素受体抗体

hz-1758R L-enk  亮氨酸脑啡肽抗体

hz-1117R GPR49/LGR5  G蛋白偶联受体49抗体

hz-4206R sLOX 1  可溶性凝集素样氧化低密度脂蛋白受体1抗体

hz-5789R GPR39  G蛋白偶联受体39抗体

hzt-0506M LH  人促黄体生成素抗体

hz-0951R LH beta  促黄体生成素抗体

hz-0952R LH  促黄体生成素抗体

hz-0984R LHR/CGR  促黄体生成素受体抗体

hz-1054R HDC  L-组氨酸脱羧酶抗体

hz-0456R LHRH/GNRH  黄体激素释放激素类似物抗体

hz-1058R LIF  白血病抑制因子抗体

hz-1458R LIFR/CD118  白血病抑制因子受体抗体

hz-1177R Lingo-1  Nogo受体反应蛋白抗体

hz-2775R LIMK1  单丝氨酸蛋白激酶1抗体

hz-3247R Phospho-LIMK1(Thr508)/LIMK2(Thr505)  磷酸化单丝氨酸蛋白激酶1/2抗体

hz-2656R LIR-6  白细胞免疫球蛋白样受体6抗体

hz-2658R LIR-8/CD85c/LILRB5  白细胞免疫球蛋白样受体8抗体

hz-2035R LIS1  无脑回的致病基因LIS1抗体

hz-2691R LILRB3/CD85a/PirB  白细胞免疫球蛋白样受体-B抗体

hz-2657R LIX1  LIX1抗体

hz-0738R Livin  凋亡抑制蛋白抗体