获取电话英文名称 FUNDC1
中文名称 X三体综合症相关蛋白FUNDC1抗体
别 名 FUN14 domain containing protein 1; FUN14 domain-containing protein 1; FUND1_HUMAN.
说 明 书 0.2ml
研究领域 细胞生物 免疫学 发育生物学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 X三体综合症相关蛋白FUNDC1抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FUNDC1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
X三体综合症相关蛋白FUNDC1抗体产品介绍 background:
FUNDC1 is a 155 amino acid protein belonging to the FUN14 family. The gene encoding FUNDC1 maps to human chromosome Xp11.3 and mouse chromosome X A1.2. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome.
Function:
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Subunit:
Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP.
Subcellular Location:
Mitochondrion outer membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18, leading to interaction with MAP1 LC3 family proteins and triggering mitophagy.
Similarity:
Belongs to the FUN14 family.
Database links:
UniProtKB/Swiss-Prot: Q8IVP5.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
X三体综合症相关蛋白FUNDC1抗体
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hz-1273P E-Selectin E选择素抗原
hz-1479P CD80/B7-1(human) 人刺激分子B7-1蛋白抗原
hz-2211P CD80/B7-1 刺激分子B7-1蛋白抗原
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hz-1448P CD339/Jagged1 CD339/Jagged1抗原
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hz-0559P CDK5(Cyclin Dependent Kinase 5) 周期素依赖性激酶5抗原
hz-0568P CDK6 (Cyclin Dependent Kinase 6) 周期素依赖性激酶6抗原
hz-0569P CDK7/Cyclin H/MAT1 周期素依赖性激酶7抗原
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