获取电话英文名称 SSX2
中文名称 滑膜肉瘤X染色体相关2抗体
别 名 CT5.2; X breakpoint 2; Cancer/testis antigen 5.2; CT5.2; HD21; hom mel 40; HOM-MEL-40; MGC119055; Protein SSX2; RP11-552J9.2; sarcoma, synovial, X-chromosome related 2; SSx; SSX2; SSX2-SYT fusion gene, included; SSX2_HUMAN; SSX2B; Synovial sarcoma; synovial sarcoma X breakpoint 2; Tumor antigen HOM-MEL-40.
滑膜肉瘤X染色体相关2抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 转录调节因子 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SSX2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
滑膜肉瘤X染色体相关2抗体 产品介绍 background:
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]
Function:
Could act as a modulator of transcription.
Subunit:
Interacts via its N-terminal region with RAB3IP and SSX2IP.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.
DISEASE:
Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
Similarity:
Belongs to the SSX family.
Contains 1 KRAB-related domain.
Database links:
Entrez Gene: 6757 Human
Entrez Gene: 727837 Human
Omim: 300192 Human
SwissProt: Q16385 Human
Unigene: 289105 Human
Unigene: 661107 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
滑膜肉瘤X染色体相关2抗体
hz-5058R ECHS1 烯脂酰辅酶A水解酶抗体
hz-4058R hzHADH 三羟酰辅酶A脱氢酶抗体
hz-0776R ECM1 细胞外基质蛋白1抗体
hz-5864R ADAMTSL4 整合素样金属蛋白酶与凝血酶样4蛋白抗体
hz-1754R ECP 嗜酸性粒细胞阳离子蛋白抗体
hz-4102R ECT2 上皮细胞癌转化蛋白2抗体
hz-5344R phospho-ECT2 (Thr790) 磷酸化上皮细胞癌转化蛋白2抗体
hz-1149R ED-1 外胚层发育不良抗体
hz-5873R CNDP1 肌肽二肽酶1抗体
hz-1757R EDNRA 内皮素受体A抗体
hz-2363R EDNRB 内皮素受体B抗体
hz-3611R EEF2 真核翻译延长因子2抗体
hz-3486R Phospho-EEF2 (Thr56) 磷酸化真核翻译延长因子2抗体
hz-3612R EEF2k 真核延伸因子激酶2抗体
hz-3487R Phospho-EEF2k (Ser366) 磷酸化真核延伸因子激酶2抗体
hz-4651R Alpha B Crystallin/HSPB5 热休克蛋白β5抗体
hz-0165R EGFR 表皮生长因子受体抗体
hz-3104R Phospho-EGFR(Ser991) 磷酸化表皮生长因子受体抗体
hz-3105R Phospho-EGFR (Thr678) 磷酸化表皮生长因子受体抗体
hz-3106R Phospho-EGFR (Ser1045) 磷酸化表皮生长因子受体抗体
hz-3109R Phospho-EGFR (Tyr1138) 磷酸化表皮生长因子受体抗体
hz-3110R Phospho-EGFR (Tyr1172) 磷酸化表皮生长因子受体抗体
hz-3111R Phospho-EGFR(Tyr845) 磷酸化表皮生长因子受体抗体
hz-3112R Phospho-EGFR (Tyr998) 磷酸化表皮生长因子受体抗体
hz-4077R Phospho-EGFR (Tyr992) 磷酸化表皮生长因子受体抗体
hz-4078R Phospho-EGFR (Tyr1101) 磷酸化表皮生长因子受体抗体
hz-2008R EGF(human) 表皮生长因子抗体（人）
hz-1644R phospho-EGFR (Tyr1068) 磷酸化表皮生长因子受体抗体
hz-5307R phospho-EGFR (Ser1026) 磷酸化表皮生长因子受体抗体
hz-5308R phospho-EGFR (Ser1166) 磷酸化表皮生长因子受体抗体
hz-5309R phospho-EGFR (Ser1190) 磷酸化表皮生长因子受体抗体
hz-5310R phospho-EGFR (Ser695) 磷酸化表皮生长因子受体抗体
hz-5311R phospho-EGFR (Ser1070) 磷酸化表皮生长因子受体抗体