结构特异性核酸酶FEN1抗体

英文名称    FEN1    

中文名称    结构特异性核酸酶FEN1抗体    

别    名    DNase IV; FEN-1; FEN1; FEN1_HUMAN; Flap endonuclease 1; Flap structure specific endonuclease 1; Flap structure-specific endonuclease 1; hFEN-1; hFEN1; Maturation factor 1; MF1; Rad2.    

说 明 书    0.2ml      

研究领域    细胞生物  免疫学  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 结构特异性核酸酶FEN1抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    42kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FEN1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

结构特异性核酸酶FEN1抗体产品介绍    background:

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

Subunit:
Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300. Can bind simultaneously to both PCNA and EP300. Interacts with DDX11.

Subcellular Location:
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.

Similarity:
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.

Database links:
Entrez Gene: 2237 Human

Entrez Gene: 14156 Mouse

Omim: 600393 Human

SwissProt: P39748 Human

SwissProt: P39749 Mouse

Unigene: 409065 Human

Unigene: 2952 Mouse

Unigene: 470595 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

结构特异性核酸酶FEN1抗体

hz-2114R AU1 tag  AU1 tag标签抗体

hz-2115R Glu-Glu Tag  Glu-Glu tag抗体

hz-2116R E Tag  E Tag标签抗体

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hz-5757R FAM13B1  FAM13B1蛋白抗体

hz-1000R CNP/CNPase  C型钠尿肽抗体

hz-1683R CNR1/CB1  钙粘蛋白相关的神经受体1抗体

hz-2377R CNR2/CB2  钙粘蛋白相关的神经受体2抗体

hz-1516R CNTFR-α  睫状神经营养因子受体α抗体

hz-1711R CNR-2/PCDHA6  钙粘蛋白相关的神经受体2抗体

hz-1272R CNTF  睫状神经营养因子抗体

hz-3099R Phospho-Cofilin(Ser3)  磷酸化丝切蛋白抗体

hz-5258R Phospho-Cofilin/CFL1 (Tyr139)  磷酸化丝切蛋白抗体

hz-5259R phospho-CFL1/CFL2 (Tyr88)  磷酸化丝切蛋白抗体

hz-2541R COLEC12  凝集胎盘蛋白1抗体

hz-0578R Collagen I  Ⅰ型胶原抗体

hz-0709R Collagen II/Chondrocalcin  Ⅱ型胶原α1蛋白/软骨钙素抗体

hz-5758R FAP/FAPA  成纤维细胞激活蛋白α抗体

hz-5760R FAP1/PTPN13  Fas相关磷酸酶1/蛋白酪氨酸磷酸酶非受体型13抗体

hz-0549R Collagen III  抗Ⅲ型胶原抗体 Collagen Ⅲ

hz-0948R Collagen III  抗Ⅲ型胶原抗体

hz-5764R CIAPIN1  细胞因子诱导凋亡抑制因子1

hz-0806R Collagen IV/Arresten  抗IV型胶原抗体

hz-0552R Collagen V  Ⅴ型胶原抗体

hz-4595R Collagen IV  抗IV型胶原抗体

hz-0553R Collagen VI alpha 1  抗Ⅵ型胶原抗体

hz-5765R LANCL2  G蛋白偶联受体69B

hz-1558R Collagen VII  7型胶原抗体

hz-5766R RAB6C  RAS癌基因相关蛋白Rab6C抗体

hz-5767R Epigen  上皮细胞有丝分裂蛋白抗体

hz-2921R PAR3  非典型蛋白激酶C特定相互作用蛋白抗体

hz-0554R Collagen X  Ⅹ型胶原抗体