肾刷状缘抗体

英文名称    Fx1A    

中文名称    肾刷状缘抗体    

别    名    gp330; RTEα5; LRP2_RAT; Low-density lipoprotein receptor-related protein 2; LRP-2; Glycoprotein 330; Megalin.    

说 明 书    0.2ml  1ml    

研究领域    免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Rat,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）肾刷状缘抗体 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    518kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    Fx1A protein    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

肾刷状缘抗体产品介绍    background:

Binding of anti-Fx1A to Heymann nephritis antigens (HA) on rat glomerular epithelial cells (GECs) in culture leads to capping and disappearance of antigens from the cell surface. This process may contribute to the formation of glomerular subepithelial immune deposits in vivo. The authors differentially extracted GECs to determine whether HA redistribution is mediated by cytoskeletal components. Observations were made by phase-contrast and immunofluorescence microscopy on primary and passaged GECs in monolayer culture and by spectrofluorimetry on GECs in suspension.

Function:
Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.

Subunit:
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP. Interacts (via NPXY motif) with DAB2; the interaction is not affected by tyrosine phosphorylation of the NPXY motif.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Cytoplasm. Note=Expressed in clathrin-coated pits, a soluble form is possibly derived by cleavage at the cell surface.

Tissue Specificity:
Epithelial cells of kidney glomerulus and proximal tubule, lung, epididymis, yolk sac, among others. 

Similarity:
Belongs to the LDLR family. 
Contains 17 EGF-like domains. 
Contains 36 LDL-receptor class A domains. 
Contains 37 LDL-receptor class B repeats. 

Database links:
UniProtKB/Swiss-Prot: P98158.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

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