获取电话英文名称 FLG
中文名称 丝聚合蛋白/中间丝蛋白抗体
别 名 filaggrin; Epidermal filaggrin; Profilaggrin; Filaggrin precursor; FILA_HUMAN; FILA_MOUSE.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 信号转导 细胞类型标志物 细胞骨架
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,
产品应用 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 丝聚合蛋白/中间丝蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 447kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse FLG
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
丝聚合蛋白/中间丝蛋白抗体产品介绍 background:
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009].
Function:
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Tissue Specificity:
Keratohyalin granules.
Post-translational modifications:
Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.
Undergoes deimination of some arginine residues (citrullination).
DISEASE:
Defects in FLG are the cause of ichthyosis vulgaris (VI) [MIM:146700]; also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever.
Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2) [MIM:605803]. Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE-mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee.
Similarity:
Belongs to the S100-fused protein family.
Contains 2 EF-hand domains.
Contains 23 filaggrin repeats.
Gene ID:
14246
Database links:
Entrez Gene: 2312 Human
Entrez Gene: 14246 Mouse
Omim: 135940 Human
SwissProt: P20930 Human
SwissProt: P11088 Mouse
Unigene: 654510 Human
Unigene: 162684 Mouse
Unigene: 439710 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝聚合蛋白/中间丝蛋白抗体
A-43 RV IgM 风疹胞病毒 IgM(捕获法二步法)
A-16-1 TOXO IgG 弓形虫抗体 IgG(间接法二步法)
A-15-1 TOXO IgM 弓形虫抗体 IgM(间接法二步法)
A-33 TOXO IgM 弓形虫抗体 IgM(捕获法一步法)
A-44 TOXO IgM 弓形虫抗体 IgM(捕获法二步法)
A-40-1 HSV- I IgG 单纯疱疹Ⅰ型病毒 IgG(间接法二步法)
A-18-1 HSV- I IgM 单纯疱疹Ⅰ型病毒 IgM(间接法二步法)
A-36 HSV- I IgM 单纯疱疹Ⅰ型病毒 IgM（捕获法一步法）
A-45 HSV- I IgM 单纯疱疹Ⅰ型病毒 IgM（捕获法二步法）
A-41-1 HSV- II IgG 单纯疱疹Ⅱ型病毒 IgG(间接法二步法)
A-19-1 HSV- II IgM 单纯疱疹Ⅱ型病毒 IgM(间接法二步法)
A-37 HSV- II IgM 单纯疱疹Ⅱ型病毒 IgM （捕获法，一步法）
A-46 HSV- II IgM 单纯疱疹Ⅱ型病毒 IgM （捕获法，二步法）
E-73-48/96 Anti-Ins 胰岛素抗体（间接法二步法）
E-81-48/96 Anti-GAD 谷氨酸脱羧酶抗体（间接法二步法）
E-82-48/96 Ins 胰岛素（间接法二步法）
E-83-48/96 C-Peptide C-肽（夹心法二步法）
E-91-48/96 破伤风抗体（双抗原夹心法）
A-31 包虫抗体IgG（间接法二步法）
hz-1012 DAO(Rat diamine oxidase,DAO) ELISA Kit 大鼠二胺氧化酶
hz-1012 Mouse anti-red cell antibody ELISA Kit 小鼠抗红细胞抗体
hz-1012 GCP-2/CXCL6(Human granulocyte chhzotactic protein-2,GCP-2) ELISA Kit 人粒细胞趋化蛋白-2
EA-1012 SAA (Rabbit Serum amyloid A) ELISA Kit 兔血清淀粉样蛋白A
EF-1012 C4 ELISA Kit 鲑鱼补体蛋白4
A-06-1 MV IgG 麻疹病毒 IgG（间接法二步法）
A-05-1 MV IgM 麻疹病毒 IgM（间接法二步法）
A-47-1 COX IgG 柯萨奇病毒 IgG 混合型（间接法二步法）
A-07-1 COX IgM 柯萨奇病毒 IgM 混合型(间接法二步法)
A-48-1 COX IgG I 柯萨奇病毒 IgG Ⅰ(间接法二步法)
A-08-1 COX IgM I 柯萨奇病毒 IgM Ⅰ(间接法二步法)
A-49-1 COX IgG II 柯萨奇病毒 IgG Ⅱ(间接法二步法)
A-50-1 COX IgG III 柯萨奇病毒 IgG Ⅲ(间接法二步法)
A-51-1 COX IgG IV 柯萨奇病毒 IgG Ⅳ(间接法二步法)
