获取电话英文名称 FBXO39
中文名称 XIAP相关因子1凋亡抑制蛋白抗体
别 名 XIAP-associated factor 1; BIRC 4 binding protein; BIRC4-binding protein; XAF1; XAF1_MOUSE; XIAPAF1; BIRC 4 binding protein; BIRC4 binding protein; BIRC4BP; HSXIAPAF 1; HSXIAPAF1; XAF 1; XIAP associated factor 1; Fbxo39; RP24-450M24.4.
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 免疫学 细胞凋亡
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 XIAP相关因子1凋亡抑制蛋白抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse XAF1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
XIAP相关因子1凋亡抑制蛋白抗体产品介绍 background:
XAF1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF1 results in the neutralization of XIAP's ability to inhibit cell death. XAF1 is normally expressed in all adult and fetal tissues but is present at very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines.
Function:
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells (By similarity).
Subunit:
Interacts with BIRC1, BIRC2, BIRC3, BIRC4, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation (By similarity).
Subcellular Location:
Cytoplasm (By similarity). Nucleus (By similarity). Mitochondrion (By similarity).
Similarity:
Contains 1 TRAF-type zinc finger.
Gene ID:
628100
XIAP相关因子1凋亡抑制蛋白抗体
hz-2179P-APhz AACT/APC 荧光素APC标记胰糜蛋白酶
hz-0437P-hzy3 Streptavidin/Cy3 荧光素Cy3标记链霉亲和素
hz-0312P-hzy3 Avidin/Cy3 荧光素Cy3标记亲合素
hz-0362P-hzy3 Protein A/Cy3 Cy3标记蛋白A
hz-0295P-hzy3 Rabbit IgG/Cy3 荧光素Cy3标记兔IgG(细胞流式同型对照)
hz-0296P-hzy3 Mouse IgG/Cy3 荧光素Cy3标记小鼠IgG(细胞流式同型对照)
hz-0294P-hzy3 Goat IgG/Cy3 荧光素Cy3标记羊IgG(细胞流式同型对照)
hz-0293P-hzy3 Rat IgG/Cy3 荧光素Cy3标记大鼠IgG(细胞流式同型对照)
hz-0326P-hzy3 Bovine IgG/Cy3 荧光素Cy3标记牛IgG
hz-0327P-hzy3 Bovine IgM/Cy3 荧光素Cy3标记牛IgM
hz-0310P-hzy3 Chicken IgG/Cy3 荧光素Cy3标记鸡IgG
hz-0314P-hzy3 Chicken IgM/Cy3 荧光素Cy3标记鸡IgM
hz-0303P-hzy3 dog IgG/Cy3 荧光素Cy3标记狗IgG
hz-0373P-hzy3 dog IgM/Cy3 荧光素Cy3标记狗IgM
hz-0370P-hzy3 Goat IgM/Cy3 荧光素Cy3标记羊IgM
hz-0358P-hzy3 Guinea pig IgG/Cy3 荧光素Cy3标记豚鼠IgG
hz-0375P-hzy3 Guinea pig IgM/Cy3 荧光素Cy3标记豚鼠IgM
hz-0308P-hzy3 Horse IgG/Cy3 荧光素Cy3标记马IgG
hz-0374P-hzy3 Horse IgM/Cy3 荧光素Cy3标记马IgM
hz-0297P-hzy3 human IgG/Cy3 荧光素Cy3标记人IgG
hz-0345P-hzy3 human IgM/Cy3 荧光素Cy3标记人IgM
hz-0360P-hzy3 human IgA/Cy3 荧光素Cy3标记人IgA
hz-0335P-hzy3 Monkey IgG/Cy3 荧光素Cy3标记猴IgG
hz-0336P-hzy3 Monkey IgM/Cy3 荧光素Cy3标记猴IgM
hz-0368P-hzy3 Mouse IgM/Cy3 荧光素Cy3标记小鼠IgM
hz-0309P-hzy3 pig IgG/Cy3 荧光素Cy3标记猪IgG
hz-0777P-hzy3 Mink IgG/Cy3 荧光素Cy3标记水貂IgG
hz-0369P-hzy3 Rabbit IgM/Cy3 荧光素Cy3标记兔IgM
hz-0346P-hzy3 Rat IgM/Cy3 荧光素Cy3标记大鼠IgM
hz-0884P-hzy3 rHIL-1Ra/Cy3 荧光素Cy3标记重组人白介素-1受体拮抗剂
hz-0789P-hzy3 Insulin Protein/Cy3 荧光素Cy3标记猪胰岛素蛋白
hz-0225P-hzy3 KLH/Cy3 荧光素Cy3标记血蓝蛋白
hz-0283P-hzy3 OVA (Ovalbumin)/Cy3 荧光素Cy3标记鸡卵白蛋白
