“衰老关键蛋白”抗体

英文名称    Fibulin 1    

中文名称    “衰老关键蛋白”抗体    

别    名    Basement membrane protein 90; BM 90; FBLN; FBLN1; FIBL 1; FIBL1; Fibulin 1; FBLN1_HUMAN; FIBL-1; Fibulin-1.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  心血管  细胞生物  免疫学  内分泌病      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 “衰老关键蛋白”抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    74kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Fibulin 1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

“衰老关键蛋白”抗体产品介绍    background:

Fibulin-1 is an extracellular matrix protein often associated with fibronectin (FN) in vivo. Fibulin-1 was found to have pronounced inhibitory effects on the cell attachment and spreading promoted by FN. Fibulin-1 was also found to inhibit the motility of a variety of cell types on FN substrata. For example, the FN-dependent haptotactic motility of breast carcinoma (MDA MB231) cells, epidermal carcinoma (A431), melanoma (A375 SM), rat pulmonary aortic smooth muscle cells (PAC1) and Chinese hamster ovary (CHO) cells was inhibited by the presence of fibulin-1 bound to FN-coated Boyden chamber membranes. Cells transfected to overproduce fibulin-1 displayed reduced velocity, distance of movement and persistence time on FN substrata. Similarly, the incorporation of fibulin-1 into FN-containing type I collagen gels inhibited the invasion of endocardial cushion mesenchymal cells migrating from cultured embryonic heart explants. By contrast, incorporation of fibulin-1 into collagen gels lacking FN had no effect on the migration of endocardial cushion cells.

Function:
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.

Subunit:
Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Interacts also with APP, NOV, FGB and HPV type 16, HPV type 18, HPV type 31 and BPV type 1 E6 proteins. Interacts with FBLN7.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells.    

“衰老关键蛋白”抗体

hz-0308P Horse IgG  (亲和纯化) 马IgG

hz-0374P Horse IgM  (亲和纯化) 马IgM

hz-0297P human IgG  (亲和纯化) 人IgG

hz-0345P human IgM  (免疫亲和纯化)人IgM

hz-0360P human sIgA  (亲和纯化) 人分泌型IgA

hz-0335P Monkey IgG  (亲和纯化) 猴IgG

hz-0336P Monkey IgM  (亲和纯化) 猴IgM

hz-0296P Mouse IgG  (免疫亲和纯化) 小鼠IgG

hz-0368P Mouse IgM  小鼠IgM (免疫亲和纯化)

hz-0309P pig IgG  (亲和纯化) 猪IgG

hz-0777P Mink IgG  水貂IgG (亲和纯化)

hz-0295P Rabbit IgG  兔IgG(亲和层析纯化)

hz-0369P Rabbit IgM  (亲和纯化) 兔IgM

hz-0293P Rat IgG  (亲和纯化) 大鼠IgG

hz-0346P Rat IgM  (亲和纯化) 大鼠IgM

hz-1781H Anthrax  炭疽沉淀素血清(马来源)

hz-1784P Anthrax Paper antigen   健康皮张炭疽抗原

hz-0360Gs Goat anti-human IgA whole serum  羊抗人IgA抗血清

hz-0356Rs Rabbit anti-digoxin whole serum  兔抗地高辛抗血清

hz-0366Rs Rabbit Anti-FITC Whole serum  兔抗荧光素抗血清

hz-0302Rs Rabbit anti-HRP whole serum  兔抗HRP抗血清

hz-0360Rs Rabbit anti-human IgA whole serum  兔抗人IgA抗血清

hzA-8s Rabbit anti-human Kappa Chain whole serum  兔抗人Kappa链抗血清（k-链抗血清）

hz-0411Rs Rabbit anti-human IgG heavy chain constant region whole serum  兔抗人IgG（γ-链）恒定区抗血清

hz-0774Rs Rabbit anti-Mouse IgA whole serum  兔抗小鼠IgA抗血清

hz-0292Rs BSA  牛血清白蛋白抗血清

hz-0292P-hzy7 BSA/Cy7  荧光素Cy7标记牛血清白蛋白

hz-0295P-hzy7 Rabbit IgG/Cy7  荧光素Cy7标记兔IgG(细胞流式同型对照)

hz-0296P-hzy7 Mouse IgG/Cy7  荧光素Cy7标记小鼠IgG(细胞流式同型对照)

hz-0294P-hzy7 Goat IgG/Cy7  荧光素Cy7标记羊IgG(细胞流式同型对照)

hz-0293P-hzy7 Rat IgG/Cy7  荧光素Cy7标记大鼠IgG(细胞流式同型对照)

hz-0295P-A555 Rabbit IgG/Alexa Fluor 555  Alexa Fluor 555标记兔IgG(细胞流式同型对照)

hz-0296P-A555 Mouse IgG/Alexa Fluor 555  Alexa Fluor 555标记小鼠IgG(细胞流式同型对照)

hz-0292P-PE BSA/PE  荧光素PE标记牛血清白蛋白