叉头蛋白P3抗体

英文名称    FoxP3    

中文名称    叉头蛋白P3抗体    

别    名    AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; foxp3; foxp3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID.    

说 明 书    0.1ml  0.2ml      

研究领域    转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 叉头蛋白P3抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    47kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human FoxP3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

叉头蛋白P3抗体产品介绍    background:

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Function:
Probable transcription factor. Plays a critical role in the control of immune response.

Subunit:
Interacts with IKZF3.

Subcellular Location:
Nucleus (Potential).

Post-translational modifications:
Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.

DISEASE:
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.

Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.

Gene ID:
50943    

叉头蛋白P3抗体

hz-0483P histone H3-like protein  组蛋白H3样蛋白多肽

hz-0620P histone H3-like protein  组蛋白H3样蛋白（C端多肽）

hz-0621P histone H3-like protein  组蛋白H3样蛋白（N端多肽）

hz-0785P HIV-1(human immunodeficiency virus type 1)  艾滋病病毒-1/人类免疫缺陷病毒1型(抗原)

hz-0786P HIV-1(human immunodeficiency virus type 1)  艾滋病病毒-1/人类免疫缺陷病毒1型(抗原)

hz-0887P Measles virus protein(Plant2 derived measles virus hhzagglutinin protein)  麻疹病毒红血球凝集素蛋白多肽

hz-0888P Measles virus protein(Plant2 derived measles virus hhzagglutinin protein)  麻疹病毒红血球凝集素蛋白多肽

hz-0664P HMGB1 (High Mobility Group Box protein 1)  高迁移率族蛋白-1(抗原)

hz-0455P HSL(hormone-sensitive lipase)  荷尔蒙敏感脂肪酸（抗原）

hz-0730P HSP-27(Heat Shock Protein 27)  热休克蛋白-27(抗原)

hz-0696P HSP-90Alpha(Heat Shock Protein 90Alpha )  热休克蛋白90α(抗原)

hz-0135P HSP-90 Beta (heat sock protein-90 Beta)  热休克蛋白-90β （抗原）

hz-0284P IASPP(inhibitory mhzber of the ASPP family)  肿瘤细胞凋亡ASPP家族的另一个成员(抗原)

hz-0608P CD54/ICAM-1  细胞间粘附分子-1

hz-0812P IL-1 Beta(Interleukin-1 Beta)  白介素1β（白细胞介素-1β）(多肽抗原)

hz-0445P IL1RAPL1 (Interleukin 1 receptor accessory protein-like 1)  白介素受体相关蛋白样1前体蛋白（抗原）

hz-0379P IL-6(Interleukin-6)  白介素6（白细胞介素-6）(多肽抗原)

hz-0698P IL-10(Interleukin-10)  白介素10（白细胞介素-10）(抗原)

hz-0780P IL-8  白介素8（白细胞介素-8）(抗原)

hz-0681P Insulin Receptor(ISR)  胰岛素受体（抗原）

hz-0641P Integrin Alpha 4/ITGA4(Integrin alpha 4)  整合素-α（抗原）

hz-0705P LDL-R(Low-density lipoprotein receptor precursor)  低密度脂蛋白受体(抗原)

hz-0722P Ki-67 peptides  Ki-67 Antigen(多肽抗原)

hz-0749P Kiss-1(Metastasis-suppressor KiSS-1 precursor)  肿瘤转移抑制基因（抗原)

hz-0864P 重组K3蛋白  重组K3蛋白

hz-2143P Snake poison Protein  蛇毒蛋白

hz-2144P Snake poison Protein  蛇毒蛋白

hz-0910P Batroxobin Protein  蛇毒巴曲酶全蛋白

hz-0409P Leptin  瘦素（抗原)

hz-0410P Leptin receptor  瘦素受体（抗原）

hz-0759P Lpin1 protein  Lpin1 protein(抗原)

hz-0484P Lumbrokinase  蚯蚓纤溶酶(蚓激酶抗原)