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一键询价英文名称 FoxP3
中文名称 叉头蛋白P3抗体
别 名 AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; foxp3; foxp3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID.
说 明 书 0.1ml 0.2ml
研究领域 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 叉头蛋白P3抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FoxP3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
叉头蛋白P3抗体产品介绍 background:
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Function:
Probable transcription factor. Plays a critical role in the control of immune response.
Subunit:
Interacts with IKZF3.
Subcellular Location:
Nucleus (Potential).
Post-translational modifications:
Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.
DISEASE:
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.
Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.
Gene ID:
50943
叉头蛋白P3抗体
hz-0483P histone H3-like protein 组蛋白H3样蛋白多肽
hz-0620P histone H3-like protein 组蛋白H3样蛋白(C端多肽)
hz-0621P histone H3-like protein 组蛋白H3样蛋白(N端多肽)
hz-0785P HIV-1(human immunodeficiency virus type 1) 艾滋病病毒-1/人类免疫缺陷病毒1型(抗原)
hz-0786P HIV-1(human immunodeficiency virus type 1) 艾滋病病毒-1/人类免疫缺陷病毒1型(抗原)
hz-0887P Measles virus protein(Plant2 derived measles virus hhzagglutinin protein) 麻疹病毒红血球凝集素蛋白多肽
hz-0888P Measles virus protein(Plant2 derived measles virus hhzagglutinin protein) 麻疹病毒红血球凝集素蛋白多肽
hz-0664P HMGB1 (High Mobility Group Box protein 1) 高迁移率族蛋白-1(抗原)
hz-0455P HSL(hormone-sensitive lipase) 荷尔蒙敏感脂肪酸(抗原)
hz-0730P HSP-27(Heat Shock Protein 27) 热休克蛋白-27(抗原)
hz-0696P HSP-90Alpha(Heat Shock Protein 90Alpha ) 热休克蛋白90α(抗原)
hz-0135P HSP-90 Beta (heat sock protein-90 Beta) 热休克蛋白-90β (抗原)
hz-0284P IASPP(inhibitory mhzber of the ASPP family) 肿瘤细胞凋亡ASPP家族的另一个成员(抗原)
hz-0608P CD54/ICAM-1 细胞间粘附分子-1
hz-0812P IL-1 Beta(Interleukin-1 Beta) 白介素1β(白细胞介素-1β)(多肽抗原)
hz-0445P IL1RAPL1 (Interleukin 1 receptor accessory protein-like 1) 白介素受体相关蛋白样1前体蛋白(抗原)
hz-0379P IL-6(Interleukin-6) 白介素6(白细胞介素-6)(多肽抗原)
hz-0698P IL-10(Interleukin-10) 白介素10(白细胞介素-10)(抗原)
hz-0780P IL-8 白介素8(白细胞介素-8)(抗原)
hz-0681P Insulin Receptor(ISR) 胰岛素受体(抗原)
hz-0641P Integrin Alpha 4/ITGA4(Integrin alpha 4) 整合素-α(抗原)
hz-0705P LDL-R(Low-density lipoprotein receptor precursor) 低密度脂蛋白受体(抗原)
hz-0722P Ki-67 peptides Ki-67 Antigen(多肽抗原)
hz-0749P Kiss-1(Metastasis-suppressor KiSS-1 precursor) 肿瘤转移抑制基因(抗原)
hz-0864P 重组K3蛋白 重组K3蛋白
hz-2143P Snake poison Protein 蛇毒蛋白
hz-2144P Snake poison Protein 蛇毒蛋白
hz-0910P Batroxobin Protein 蛇毒巴曲酶全蛋白
hz-0409P Leptin 瘦素(抗原)
hz-0410P Leptin receptor 瘦素受体(抗原)
hz-0759P Lpin1 protein Lpin1 protein(抗原)
hz-0484P Lumbrokinase 蚯蚓纤溶酶(蚓激酶抗原)