凋亡调节基因之一抗体

英文名称    CASP8 and FADD-like apoptosis regulator subunit p43    

中文名称    凋亡调节基因之一抗体    

别    名    CASP8 and FADD-like apoptosis regulator subunit p43; Flice-like Inhibitory protein; c FLIP; c FLIPL; c FLIPR; c FLIPS; c-FLIP; CASH; CASP8 and FADD like apoptosis regulator; CASP8 and FADD like apoptosis regulator precursor; CASP8AP1; Caspase Eight Related Protein; Caspase homolog; Caspase Homologue; Caspase Like Apoptosis Regulatory Protein; Caspase related inducer of apoptosis; CASPER; Cellular FLICE like inhibitory protein; CFLA; CFLAR; CLARP; FADD like anti apoptotic molecule; FADD Like Anti-apoptotic Molecule 1; FADD-like antiapoptotic molecule 1; FADD like antiapoptotic molecule 1; FADD Like Apoptosis Regulator; FLAME 1; FLAME; FLAME1; FLAME-1; FLICE Inhibitor Protein; FLIP; FLIPs; I FLICE; I-FLICE; Inhibitor of FLICE; Inhibitor of FLICE; MACH Related Inducer of Toxicity; MACH-related inducer of toxicity; mFLIP; MRIT; USURPIN; Usurpin beta; FLICE-like inhibitory protein short form; FLICE-like inhibitory protein long form; CFLAR_HUMAN; Cellular FLICE-like inhibitory protein.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  信号转导  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 凋亡调节基因之一抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    12/43kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CASP8 and FADD-like apoptosis regulator subunit p43    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

凋亡调节基因之一抗体产品介绍    background:

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Function:
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Subunit:
TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.

Tissue Specificity:
Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.

Post-translational modifications:
Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.

Similarity:
Belongs to the peptidase C14A family. 
Contains 2 DED (death effector) domains.

Gene ID:
8837    

凋亡调节基因之一抗体

hz-1702P Fut4/CD15/SSEA-1(Stage-specific hzbryonic surface antigen 1)  阶段特异性胚胎表面抗原-1抗原

hz-1137P SSTR1 (somatostatin receptor 1)  生长抑素受体1(SSTR1)抗原

hz-1138P SSTR2 (somatostatin receptor 2)  生长抑素受体2抗原

hz-1368P SSTR3 peptide  生长抑素受体3抗原

hz-1139P SSTR5 (somatostatin receptor 5)  生长抑素受体5抗原

hz-1317P STAT1(signal transducers and activators of transcription 1)  信号转导与转录激活因子1抗原

hz-1657P phospho-STAT1(p-Tyr701) peptide  磷酸化信号转导与转录激活因子1抗原

hz-1141P STAT3(signal transducers and activators of transduction3)  信号转导和转录激活因子3抗原

hz-1142P STAT5(signal transducers and activators of transduction5)  信号转导和转录激活因子5(STAT5)抗原

hz-1143P STAT6(signal transducers and activators of transduction 6)  信号转导和转录激活因子6抗原

hz-0629P SULT1E1(Estrogen Sulfotranferase)  雌激素硫酸转移酶抗原

hz-1499P SUMO  类泛素蛋白

hz-0622P Gamma-Synuclein/SNCG  核突触蛋白-γ抗原

hz-0885P phospho-Tau protein (pThr489) peptide  磷酸化微管相关蛋白多肽

hz-1369P MAP-2(microtubule associated protein 2)  微管相关蛋白2抗原

hz-1847P MAP1A/Mtap1a(microtubule associated protein 1A)  微管相关蛋白1A抗原

hz-1104P TBX2/T-box2(T-box Protein 2)  新型抑癌基因(多肽)

hz-1280P TCF7L2(transcription factor 7-like 2)  转录因子7类似物2抗原

hz-0822P TDP-43/TARDBP (tar DNA binding protein)  Tar DNA 结合蛋白43抗原

hz-1039P Tenascin  固生蛋白抗原

hz-2101P Thz 1/CD248(Tumor endothelial marker 1 precursor)  内涎蛋白/内皮唾液酸蛋白抗原

hz-0535P TFF3 (trefoil factor3)  三叶肽因子3(多肽)

hz-1144P TFPI-2 (tissue factor pathway inhibitor-2)  组织因子途径抑制剂-2抗原

hz-1838P TIEG1/KLF10(TGF-beta inducible early response gene 1)  TGF-β诱导早期应答基因1抗原

hz-0638P TGF- BetaR1/ALK (TGF-beta receptor type I)  转移生长因子–β受体1抗原

hz-1276P Erdj5/DNAJC10  Erdj5/DNAJC10多肽

hz-1334P Tie1/JTK14 peptide  上皮生长因子样域酪氨酸激酶1抗原

hz-1300P Tie2(Porcine tyrosine kinase with immunoglobulin-like and EGF-like domains 2)  上皮生长因子样域酪氨酸激酶2抗原

hz-1501P Rarres2/TIG2/Chhzerin(Retinoic acid receptor responder protein 2)  视黄酸受体应答蛋白2抗原

hz-1444P TLR3 (Toll-like receptor 3)  Toll样受体3抗原

hz-1021P TLR4/CD284 (Toll-like receptor 4)  Toll样受体4抗原

hz-1197P TLR5/CD285 (Toll-like receptor 5)  Toll样受体5抗原