衰老关键蛋白抗体

英文名称    Fibulin 5    

中文名称    衰老关键蛋白抗体    

别    名    ARMD3; Dance; Developmental arteries and neural crest EGF like protein; FBLN5; FIBL 5; Developmental arteries and neural crest EGF-like protein; EVEC; Fbln5; FBLN5_HUMAN; UP50; FIBL 5; FIBL-5; Fibulin-5; FLJ90059; Urine p50 protein.    

说 明 书    0.2ml      

研究领域    心血管  免疫学  信号转导  内分泌病  细胞骨架  细胞外基质      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 衰老关键蛋白抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Fibulin 5    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

衰老关键蛋白抗体产品介绍    background:

Fibulin 5: A protein that belongs to a family of extracellular proteins expressed in the basement membranes of blood vessels. Fibulin 5 may be essential for the polymerization of elastin. Missense mutations in FBLN5, the gene that encodes fibulin 5, appear responsible for 1-2% of cases of age-related macular degeneration (AMD). FBLN5 is located on chromosome 14 in band 14q32.1. See also: Fibulin 3. May play a role in vascular growth and maturation during development and in lesions of injured vessels.

Function:
Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.

DISEASE:
Cutis laxa, autosomal dominant, 2 (ADCL2) [MIM:614434]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. Additional variable clinical features are gastrointestinal diverticula, hernia, and genital prolapse. Rare manifestations are pulmonary artery stenosis, aortic aneurysm, bronchiectasis, and emphysema. Note=The disease is caused by mutations affecting the gene represented in this entry. 
Cutis laxa, autosomal recessive, 1A (ARCL1A) [MIM:219100]: A connective tissue disorder characterized by loose, hyperextensible skin with decreased resilience and elasticity leading to a premature aged appearance. Face, hands, feet, joints, and torso may be differentially affected. The clinical spectrum of autosomal recessive cutis laxa is highly heterogeneous with respect to organ involvement and severity. Type I autosomal recessive cutis laxa is a specific, life-threatening disorder with organ involvement, lung atelectasis and emphysema, diverticula of the gastrointestinal and genitourinary systems, and vascular anomalies. Associated cranial anomalies, late closure of the fontanel, joint laxity, hip dislocation, and inguinal hernia have been observed but are uncommon. Note=The disease is caused by mutations affecting the gene represented in this entry.
Age-related macular degeneration 3 (ARMD3) [MIM:608895]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the fibulin family.
Contains 6 EGF-like domains.

Gene ID:
10516    

衰老关键蛋白抗体

hz-1122P Shza3F (shzaphorin 3F)  臂板蛋白3F抗原

hz-1303P SFRP1(Secreted frizzled related protein 1)  分泌型卷曲相关蛋白1抗原

hz-1128P SGLT1(sodium-glucose cotransporter1)  钠-葡萄糖共转运载体1抗原

hz-2149P Shadow/SPRN(Shadow of prion protein precursor)  新朊蛋白/朊蛋白相关蛋白/沙杜（Shadoo）蛋白抗原

hz-0882P Shiga-like toxin IIe variant subunit A 0139[Escherichia coli 0139]  大肠杆菌志贺样毒素Ⅱ型突变体（O139菌型）

hz-0944P Shiga-like toxin IIe variant subunit A[Escherichia coli 0139]  大肠杆菌志贺样毒素菌体蛋白（O139菌型）

hz-1233P SHP2 peptide  蛋白酪氨酸磷酸酶2抗原

hz-1130P SIP1 peptide  运动神经元存活蛋白结合蛋白1抗原

hz-0921P SIRT1(sirtuin 1)  沉默调节蛋白1抗原

hz-1096P Skp2 peptide  细胞S相激酶相关蛋白抗原

hz-2096P SLC4A4(solute carrier family 4:sodium bicarbonate cotransporter NBC1)  碳酸氢钠协同转运蛋白4-A4

hz-1530P Slc4a7/Nbcn1(solute carrier family 4, sodium bicarbonate cotransporter, mhzber 7)  碳酸氢钠协同转运蛋白4-A7抗原

hz-1298P Smac/DIABLO(the second mitochondrial activator of caspase)  线粒体促凋亡蛋白抗原

hz-0699P SLC33A1(Acetyl-coenzyme A transportor 1)  乙酰辅酶A转运蛋白1抗原

hz-0856P SLC34A2/NaPi-2b(Solute carrier family 34 mhzber 2)  磷酸钠协同转运蛋白抗原

hz-2034P SMN1(survival of motor neuron 1)  运动神经元生存蛋白1抗原

hz-2224P phospho-Smad2(p-Ser465)petide  磷酸化Smad2抗原

hz-0585P Smad4(Mothers against decapentaplegic homolog 4)  Smad4抗原

hz-0566P Smad7(Mothers against decapentaplegic homolog 7)  Smad 7(多肽)

hz-0457P phosphor-SMAD(p-Ser425)、phosphor-Mothers against decapentaplegic  磷酸化SMAD(p-Ser425)抗原

hz-1131P SNAP-25 (synaptosomal-associated protein 25)  突触相关膜蛋白25抗原

hz-1371P Snail  Snail蛋白抗原

hz-0580P Socs 3 (suppressor of cytokine signaling 3)  细胞因子信号传导抑制蛋白3抗原

hz-1079P SOD1(superoxide-dimutase-1)  超氧化物歧化酶1抗原

hz-1080P SOD2 (superoxide-dimutase-2)  超氧化物歧化酶2抗原

hz-1132P Somatostatin/GRIH  生长抑素抗原

hz-0523P Sox2  胚胎干细胞关键蛋白

hz-0975P TSFP1/SP1(transcription factor Sp1)  SP1转录生长因子抗原

hz-1133P SPARC (secreted protein acidic and rich in cysteine)  富含半胱氨酸的酸性分泌蛋白抗原

hz-1401P SRF(Serum response factor)  血清应答因子抗原

hz-1402P SREBP-1(Sterol Regulatory Elhzent Binding Protein-1)  固醇调节元件结合蛋白1抗原

hz-1381P AKAP12A/SSeCKS peptide  丝氨酸抑制蛋白激酶C底物抗原