跨膜通道蛋白8抗体

英文名称    EVER2    

中文名称    跨膜通道蛋白8抗体    

别    名    epidermodysplasia verruciformis 2; Epidermodysplasia verruciformis protein 2; EV2; EVIN2; FLJ40668; FLJ43684; MGC102701; MGC40121; TMC8; Transmembrane channel like protein 8; TMC8_HUMAN.    

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  跨膜蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 跨膜通道蛋白8抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    82kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EVER2/TMC8    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

跨膜通道蛋白8抗体产品介绍    background:

Transmembrane channel-like protein 8 (TMC8), also known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino acid member of the TMC family of proteins. Localized to the endoplasmic reticulum membrane, TMC8 is thought to form a transmembrane channel-like protein with eight predicted transmembrane domains and three leucine zipper motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like or macular lesions. TMC8 is expressed in placenta, prostate and testis, and three named isoforms exist as a result of alternative splicing events.

Function:
Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least two isoforms of EVER2 are known to exist.

Subcellular Location:
Endoplasmic reticulum membrane; Multi pass membrane protein.

Tissue Specificity:
Expressed in placenta, prostate and testis. 

DISEASE:
Defects in TMC8 are a cause of epidermodysplasia verruciformis (EV) [MIM:226400]. It is a rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions. 

Similarity:
Belongs to the TMC family. 

Database links:

Entrez Gene: 147138 Human

Entrez Gene: 217356 Mouse

Omim: 605829 Human

SwissProt: Q8IU68 Human

SwissProt: Q7TN58 Mouse

Unigene: 592102 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

跨膜通道蛋白8抗体

hz-2183P Claudin-11 peptide  少突胶质细胞跨膜蛋白抗原

hz-0790P CLDN1(Claudin 1)C-term  紧密连接蛋白1抗原(C端)

hz-0582P COX-1 (Prostaglandin-endoperoxide synthase-1)  前列腺素氧化环化酶1抗原

hz-2047P CPT1A peptide  肉毒碱棕榈酰基转移酶1A多肽抗原

hz-1790P CRMP2/Dpysl2(collapsin response mediator protein-2)  二氢嘧啶酶样2CRMP2抗原

hz-1860P CRLR/CALCRL(calcitonin receptor like precursor)  降钙素受体样蛋白抗原

hz-1703P cRaf/Raf1(c-raf 1)  cRaf/Raf1抗原

hz-1433P MEK1/MAPKK1(mitogen activated protein kinase kinase 1)  MEK1/MAPKK1抗体(N-端)

hz-0382P CRF (Corticotropin-Releasing Factor)  促肾上腺皮质激素释放因子

hz-0793P CSIG(cellular senescence inhibited gene)  细胞衰老抑制基因抗原

hz-1566P Cripto-1(N-Terminus)  畸胎瘤衍化生长因子抗原(表皮生长因子相关肽)N端

hz-2141P Cripto-1(C-Terminus)  畸胎瘤衍化生长因子抗原(表皮生长因子相关肽)C端

hz-0848P Anti-CSP (circumsporozoite protein/Plasmodium yoelii)  环子孢子蛋白(约氏疟原虫)抗原

hz-2174P Calcitonin  降钙素抗原

hz-1410P CTBP1(C-terminal binding protein 1)  C端结合蛋白1抗原

hz-1179P CTLA-4/CD152  淋巴细胞相关抗原4/细胞毒性T细胞抗原-4

hz-0799P CTn1 (cardiac troponin 1)  心肌肌钙蛋白

hz-1376P Cx32(Connexin-32)  间隙连接蛋白32抗原

hz-1266P CX36 (Connexin-36)  间隙连接蛋白36抗原

hz-1050P Cx40 (Connexin-40)  间隙连接蛋白40(多肽)

hz-0811P cx3cl1(chhzokine (C-X3-C motif) ligand 1)  趋化因子(C-X3-C 基元)配体1抗原

hz-1728P CX3CR1(CX3C-chhzokine receptor 1)  CX3C趋化因子受体1抗原

hz-0571P Cyclin A  周期素A抗原

hz-0572P Cyclin B1  周期素B1抗原

hz-1148P Cyclin D2  周期素D2抗原

hz-0660P Cyclin D3(C-term)  周期素D3抗原

hz-1742P CYP3A4(Cytochrome p450 3A4)  细胞色素P450 3A4抗原

hz-1290P Cyr61/IGFBP10/CCN1(cysteine rich 61)  富半胱氨酸肝素结合蛋白61抗原

hz-0896P HCMV UL23/HHV5 UL23(Human Cytomegalovirus UL23 Gene)  人巨细胞病毒UL23抗原

hz-1007P DAD1 (dopamine D1 receptor)  多巴胺受体-D1抗原

hz-1743P DRD3 receptor(dopamine D3 receptor)  多巴胺受体-D3抗原

hz-1746P DRD4 receptor peptide  多巴胺受体-D4抗原

hz-1747P DRD5 receptor(dopamine D5 receptor)  多巴胺受体-D5抗原

hz-0596P DBH (Dopamine- Beta-Hydroxylase)  多巴胺β羟化酶（抗原）