T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体

英文名称    ETEA    

中文名称    T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体    

别    名    AI462440; expressed in T cells and eosinophils in atopic dermatitis; faf2; FAF2_HUMAN; Fas associated factor family member 2; FAS-associated factor 2; KIAA0887; Protein ETEA; Protein expressed in T cells and eosinophils in atopic dermatitis; Protein expressed in T-cells and eosinophils in atopic dermatitis; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3B.    

说 明 书    0.2ml      

研究领域    细胞生物  细胞凋亡  淋巴细胞  t-淋巴细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    53kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ETEA    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体产品介绍    background:

ETEA is a 445-amino acid protein associated with atopic dermatitis (AD), a chronic noncontagious relapsing inflammatory skin disease characterized by eczematous skin lesions and also referred to as eczematous dermatitis. Other atopic diseases such as hay fever, asthma and conjunctivitis often occur along with AD. ETEA shows higher expression in T cells and eosinophils of patients with AD than in T cells and eosinophils of unaffected individuals. T cells are influential in the regulation of the inflammatory process of this disease. The persistence of jAD is attributed to dysregulated apoptosis in T cells, eosinophils, and keratinocytes. ETEA may be involved in the resistance to apoptosis in T cells and eosinophils of AD patients. 

Function:
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Subunit:
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1.

Subcellular Location:
Cytoplasm. Lipid droplet. Endoplasmic reticulum.

Tissue Specificity:
Broadly expressed, with highest levels in brain.

Similarity:
Contains 1 UBX domain.

Database links:
UniProtKB/Swiss-Prot: Q96CS3.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

T细胞和嗜酸性粒细胞表达特应性皮炎蛋白ETEA抗体

hz-0163P NOS-3 (eNOS) endotheli cell NOS  一氧化氮合成酶-3（抗原）

hz-0071P NPY ( Neuropeptide Y)  神经肽 Y（抗原）

hz-0222P NR2B (Glutamate receptor)  谷氨酸受体（抗原）

hz-0160P NT-3  神经生长因子-3（抗原）

hz-0158P NT-4,NT-5  神经生长因子4/5（抗原）

hz-0073P NTN (Neurturin)  神经生长因子（抗原）

hz-1336P Bcl-xL(human, mo, rat, bovine, dog, pig, sheep, horse)  Bcl-xL蛋白抗原

hz-1337P phospha-Bcl-xL (pSer62) peptide (human, mo, rat, bovine, dog, pig, sheep, horse)  磷酸化(Ser62)Bcl-xL蛋白抗原

hz-0986P BCHE(butyrylcholinesterase)NT  丁酰胆碱脂酶抗原(N端)

hz-0987P BCHE(butyrylcholinesterase)CT  丁酰胆碱脂酶抗原(C端)

hz-0178P Nurr1  核受体相关因子-1（抗原）

hz-0372P NT5C2  胞浆-5′-核苷酸酶-Ⅱ

hz-1353P BECN1(Beclin1)  一种抑癌基因（多肽）

hz-0240P OGP (Ostegenic Growth Peptide)  成骨生长肽 (骨生长激素肽)(蛋白多肽)

hz-0019P OPN  骨桥蛋白（多肽抗原）

hz-2431P BAFF/CD257(B cell activating factor)  TNF家族B细胞激活因子抗原

hz-0033P P53  肿瘤抑制基因（抗原）

hz-0190P PACAP-27/38  腺苷酸环化酶激活肽-27/38（抗原）

hz-0200P PACAP-38  腺苷酸环化酶激活肽-38（抗原）

hz-1153P Bid (BH3 interacting domain death agonist)  BH3结构域凋亡诱导蛋白抗原

hz-2357P PACAP(6-38 Peptide)  腺苷酸环化酶激活肽6-38

hz-0197P PACAP/VIP receptor  腺苷酸环化酶激活肽/血管活性肠肽受体（抗原）

hz-0198P PACAP receptor-I  腺苷酸环化酶激活肽受体（抗原）

hz-0318P PADI4 (HL-60 PAD)(Protein-arginine deiminase type IV，PADI 4，PAD I4 )  关节炎相关基因

hz-0196P PDGF-A  血小板源性生长因子-1（抗原）

hz-0185P PDGF-B  血小板源性生长因子-B（抗原）

hz-0231P PDGF-R-A  血小板源性生长因子受体-A（抗原）

hz-0232P PDGF-R-B  血小板源性生长因子受体-B（抗原）

hz-0235P PMP-22(Peripheral Myelin Protein)  外周髓鞘蛋白-22多肽

hz-0128P PI3K  磷脂酰肌醇激酶（抗原）

hz-1374P BMP4(bone morphogenetic protein 4)  骨形态发生蛋白4（抗原）

hz-0234P PLGF (Placenta growth factor)  小鼠胎盘生长因子（多肽抗原）

hz-0280P PLGF (Placenta growth factor)  胎盘生长因子（多肽抗原）