找不到产品?留下需求帮您找
一键询价英文名称 Epac2
中文名称 鸟嘌呤核苷酸交换因子4
别 名 CAMP GEFII; cAMP regulated guanine nucleotide exchange factor II; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CAMPGEFII; CGEF 2; CGEF2; Epac 2; EPAC2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; Nbla00496; Putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; RAP guanine nucleotide exchange factor 4; RAPGEF 4; RAPGEF4; RPGF4_HUMAN.
说 明 书 0.2ml
研究领域 细胞生物 神经生物学 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 鸟嘌呤核苷酸交换因子4(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 116kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Epac2/RAPGEF4
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
鸟嘌呤核苷酸交换因子4产品介绍 background:
3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the ras family GTPases Rap1 and Rap2 by promoting GTP binding in a cAMP-dependent manner (1,2). Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission (3). Human EPAC2 contains at least 31 exons and maps to chromosome 2q31 (4). The 4.4-kb Epac2 transcript is prominent in brain and adrenal gland (5,6). Within the brain, expression is strong in cortex, occipital pole, frontal lobe, temporal lobe, amygdala, putamen, hippocampus and cerebellum (5,6).
Function:
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
Subunit:
Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A (By similarity).
Subcellular Location:
Cytoplasm. Membrane.
Tissue Specificity:
Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
Similarity:
Contains 2 cyclic nucleotide-binding domains. Contains 1 DEP domain.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 Ras-GEF domain.
鸟嘌呤核苷酸交换因子4
hz-0377R-AF647 Rabbit Anti-mouse IgG-Fc/Alexa Fluor 647 Alexa Fluor 647标记的兔抗小鼠IgG-Fc
hz-0377R-PE-hzy5.5 Rabbit Anti-mouse IgG-Fc/PE-Cy5.5 PE-Cy5.5标记的兔抗小鼠IgG-Fc
hz-0377R-PE-hzy7 Rabbit Anti-mouse IgG-Fc/PE-Cy7 PE-Cy7标记的兔抗小鼠IgG-Fc
hz-0377R-AP Rabbit Anti-mouse IgG-Fc/AP 碱性磷酸酶(AP)标记的兔抗小鼠IgG-Fc
hz-0377R-Gold Rabbit Anti-mouse IgG-Fc/Gold 胶体金标记的兔抗小鼠IgG-Fc
hz-0377R-hzy3 Rabbit Anti-mouse IgG-Fc/Cy3 Cy3标记的兔抗小鼠IgG-Fc
hz-0377R-hzy5 Rabbit Anti-mouse IgG-Fc/Cy5 Cy5标记的兔抗小鼠IgG-Fc
hz-0377R-hzy5.5 Rabbit Anti-mouse IgG-Fc/Cy5.5 Cy5.5标记的兔抗小鼠IgG-Fc
hz-0377R-hzy7 Rabbit Anti-mouse IgG-Fc/Cy7 Cy7标记的兔抗小鼠IgG-Fc
hz-0377R-PE Rabbit Anti-mouse IgG-Fc/PE PE标记的兔抗小鼠IgG-Fc
hz-0377R-FIThz Rabbit Anti-mouse IgG-Fc/FITC FITC标记的兔抗小鼠IgG-Fc
hz-0377R-RBIThz Rabbit Anti-mouse IgG-Fc/RBITC 罗丹明标记的兔抗小鼠IgG-Fc
hz-0377R-Bio Rabbit Anti-mouse IgG-Fc/Bio 生物素标记的兔抗小鼠IgG-Fc
hz-0335R-RBIThz Rabbit Anti-Monkey IgG/RBITC 罗丹明标记的兔抗猴IgG
hz-0335R-FIThz Rabbit Anti-Monkey IgG/FITC FITC标记的兔抗猴IgG
hz-0335R-HRP Rabbit Anti-Monkey IgG/HRP 辣根过氧化物酶标记的兔抗猴IgG
hz-0335R-Gold Rabbit Anti-Monkey IgG/Gold 胶体金标记的兔抗猴IgG
hz-0335R-AP Rabbit Anti-Monkey IgG/AP 碱性磷酸酶(AP)标记的兔抗猴IgG
hz-0335R-Bio Rabbit Anti-Monkey IgG/Bio 生物素标记的兔抗猴IgG
hz-0335R-hzy3 Rabbit Anti-Monkey IgG/Cy3 Cy3标记的兔抗猴IgG
hz-0335R-hzy5 Rabbit Anti-Monkey IgG/Cy5 Cy5标记的兔抗猴IgG
hz-0335R-hzy5.5 Rabbit Anti-Monkey IgG/Cy5.5 Cy5.5标记的兔抗猴IgG
hz-0335R-hzy7 Rabbit Anti-Monkey IgG/Cy7 Cy7标记的兔抗猴IgG
hz-0335R-PE Rabbit Anti-Monkey IgG/PE PE标记的兔抗猴IgG
hz-0335R-PE-hzy3 Rabbit Anti-Monkey IgG/PE-Cy3 PE-Cy3标记的兔抗猴IgG
hz-0335R-PE-hzY5 Rabbit Anti-Monkey IgG/PE-CY5 PE-CY5标记的兔抗猴IgG
hz-0335R-APhz Rabbit Anti-Monkey IgG/APC APC标记的兔抗猴IgG
hz-0335R-AF350 Rabbit Anti-Monkey IgG/Alexa Fluor 350 Alexa Fluor 350标记的兔抗猴IgG
hz-0335R-AF488 Rabbit Anti-Monkey IgG/Alexa Fluor 488 Alexa Fluor 488标记的兔抗猴IgG
hz-0335R-AF555 Rabbit Anti-Monkey IgG/Alexa Fluor 555 Alexa Fluor 555标记的兔抗猴IgG
hz-0335R-AF647 Rabbit Anti-Monkey IgG/Alexa Fluor 647 Alexa Fluor 647标记的兔抗猴IgG
hz-0335R-PE-hzy5.5 Rabbit Anti-Monkey IgG/PE-Cy5.5 PE-Cy5.5标记的兔抗猴IgG