空通气孔样蛋白2抗体

英文名称    EMX2    

中文名称    空通气孔样蛋白2抗体    

别    名    Empty spiracles homeobox 2; Empty spiracles homolog 2 (Drosophila); Empty spiracles homolog 2; Empty spiracles like protein 2; Empty spiracles-like protein 2; EMX 2; EMX2; EMX2_HUMAN; Homeobox protein EMX 2; Homeobox protein EMX2.    

说 明 书    0.2ml      

研究领域    细胞生物  神经生物学  信号转导  干细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 空通气孔样蛋白2抗体（石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    28kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EMX2 (151-250aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

空通气孔样蛋白2抗体产品介绍    background:

Emx1 and Emx2 are human homologs to the Drosophila developmental genes empty spiracles expressed in anterior body regions during early Drosophila embryogenesis. Emx1 and Emx2 are homeobox proteins expressed in the developing vertebrate brain. Emx2 is expressed in the dorsal telencephalon and small diencephalic regions, while Emx1 expression is exclusively confined to pyramidal neurons of the dorsal telencephalon. In the embryonic brain, Emx1 is expressed in both proliferating and differentiating neurons while Emx2 is expressed only in proliferating neurons. OTX1 and OTX2 are human homologs of the Drosophila developmental genes orthodenticle. In development, the sequence of expression begins with OTX2 at day ten post coitum followed by OTX1, Emx2 and finally Emx1. The genes encoding human Emx1 and Emx2 map to chromosomes 2p13.2 and 10q26.11, respectively.

Function:
Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.

Subcellular Location:
Nucleus.

Tissue Specificity:
Cerebral cortex.

DISEASE:
Defects in EMX2 are the cause of schizencephaly (SCHZC) [MIM:269160]. Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro-spinal fluid.

Similarity:
Belongs to the EMX homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:
UniProtKB/Swiss-Prot: Q04743.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

空通气孔样蛋白2抗体

hz-5422R PP1C gamma  蛋白磷酸酶γ1抗体

hz-0029R PP2A alpha/beta  蛋白质磷酸酶-2A抗体

hz-4162R PP2CA/PPM1A  蛋白磷酸酶2C亚型α抗体

hz-5586R phospho-PPM1A(Ser375)  磷酸化蛋白磷酸酶2C亚型α抗体

hz-0490R PP2Ac/PP4C  磷酸酯酶-2Ac抗体

hz-0250R PPAR-delta/beta  D型-过氧化酶活化增生受体抗体

hz-3614R PPAR alpha  α型-过氧化酶活化增生受体抗体

hz-4055R phospho-PPAR alpha(Ser12)  磷酸化α型-过氧化酶活化增生受体抗体

hz-0530R PPAR gamma  过氧化酶活化增生受体γ抗体

hz-3737R Phospho-PPAR Gamma (ser112)  磷酸化过氧化酶活化增生受体γ抗体

hz-5912R PPIA/Cyclophilin A  亲环蛋白（亲环素）PPIA抗体

hz-5911R PPIB/Cyclophilin B  亲环蛋白（亲环素）PPIB抗体

hz-3536R PPIG  亲环蛋白（亲环素）PPIG抗体

hz-3461R Phospho-PPIG (Ser376)  磷酸化亲环蛋白（亲环素）PPIG抗体

hz-2398R PPIL1  亲环素相关蛋白1抗体

hz-0115R AKT/PKB  蛋白激酶B

hz-0876R phospho-AKT/PKB(Ser473)  磷酸化蛋白激酶B抗体

hz-2720R phospho-Akt(Thr308)  磷酸化蛋白激酶B抗体

hz-5182R phospho-AKT1/AKT2(Thr308+Thr309)  磷酸化蛋白激酶B抗体

hz-5188R phospho-AKT1(Ser129)  磷酸化蛋白激酶B抗体

hz-3043R phospho-Akt(Thr450)  磷酸化蛋白激酶B抗体

hz-3073R Phospho-HDAC4(Ser246)/HDAC5(Ser259)/HDAC7(Ser155)  磷酸化组蛋白去乙酰化酶4/5/7抗体

hz-3211R Phospho-HDAC4(Ser632)/HDAC5(Ser498)/HDAC7(Ser486)  磷酸化组蛋白去乙酰化酶4/5/7抗体

hz-4296R hnRNP K  异质核糖核蛋白K抗体

hz-5194R phospho-AKT1(Thr34)  磷酸化蛋白激酶B抗体

hz-5390R Seladin 1/DHCR24  24脱氢胆固醇还原酶抗体

hz-0875R PKN2  蛋白激酶N2抗体

hz-1436R RKIP/PBP  磷脂酰乙醇胺结合蛋白1抗体

hz-1493R EIF2AK2/PKR  蛋白激酶R抗体

hz-3335R Phospho-PKR (Thr446)  磷酸化蛋白激酶R抗体

hz-3336R Phospho-PKR (Thr451)  磷酸化蛋白激酶R抗体

hz-3337R Phospho-PKR (Thr446/451)  磷酸化蛋白激酶R抗体

hz-2056R AKT2  蛋白激酶B2

hz-4089R phospho-AKT2 (Ser474)  磷酸化蛋白激酶B2抗体