英文名称 protein 4.2
中文名称 红细胞膜蛋白4.2抗体
别 名 protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5.
说 明 书 0.2ml
研究领域 心血管 细胞表面分子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 红细胞膜蛋白4.2抗体(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human EPB42/protein 4.2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
红细胞膜蛋白4.2抗体产品介绍 background:
protein 4.2; protein4.2; EPB42; EPB42_HUMAN; Erythrocyte membrane protein band 4.2; Erythrocyte protein 4.2; Erythrocyte surface protein band 4.2; MGC116735; P4.2; PA; SPH5.
Function:
Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
Subunit:
Oligomer. Interacts with the cytoplasmic domain of SLC4A1/band 3 anion transport protein.
Subcellular Location:
Cell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes.
Post-translational modifications:
Both cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.
DISEASE:
Defects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
Similarity:
Belongs to the transglutaminase superfamily. Transglutaminase family.
Database links:
Entrez Gene: 2038 Human
Omim: 177070 Human
SwissProt: P16452 Human
Unigene: 368642 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Involvement in disease:Defects in EPB42 are the cause of spherocytosis type 5 (SPH5); also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
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